[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-veni-2017":3,"awarded-stats-nwo-veni":201},{"awarded":4,"total":200},[5,16,22,28,34,40,46,51,56,61,66,72,77,82,89,96,101,106,112,117,123,128,134,141,148,153,159,161,166,173,178,184,189,194],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award--veni-grant-863-14-010","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Veni","Early mortality saves energy: estimating the energetic cost of excess offspring in a seabird","Oscar Vedder","University of Groningen","NL",2017,null,"Offspring are often produced in excess as insurance against stochastic events or unpredictable resources. This strategy may result in high early-life mortality, yet age-specific mortality before offspring independence and its associated costs have rarely been quantified. In this study, we modelled age-specific survival from hatching to fledging using 24 years of data on hatching order (HO), growth and age of mortality of more than 15 000 common tern ( Sterna hirundo ) chicks. We found that morta",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-016-135-135-","The role of alcohol in expectancy-driven mystical experiences: a pre-registered field study using placebo brain stimulation","David L. R. Maij","University of Amsterdam","We explored the effects of alcohol on expectancy-driven mystical and quasi-mystical experiences by manipulating participants’ expectations. By using the so-called God Helmet suggestion, participants were led to believe that a placebo brain stimulation could elicit mystical experiences. In this pre-registered field study, we set out to test whether alcohol could increase participants’ susceptibility to the God Helmet suggestion in a large sample (N = 193) at a Dutch festival. Participants reporte",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-veni-171-068","Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder","Annika Rausch","Radboud University Nijmegen","Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F 1 = 7.842, p = .008) and its volume correlated significantly with sy",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":12,"year":13,"amount":14,"abstract":33},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-722-013-003","Baculoviral delivery of CRISPR\u002FCas9 facilitates efficient genome editing in human cells","Susanne M.A. Lens","University Medical Center Utrecht","The CRISPR\u002FCas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR\u002FCas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRIS",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-91612147","Circadian networks in human embryonic stem cell‐derived cardiomyocytes","Pieterjan Dierickx","Utrecht University","Abstract Cell‐autonomous circadian oscillations strongly influence tissue physiology and pathophysiology of peripheral organs including the heart, in which the circadian clock is known to determine cardiac metabolism and the outcome of for instance ischemic stress. Human pluripotent stem cells represent a powerful tool to study developmental processes in vitro , but the extent to which human embryonic stem ( ES ) cell‐derived cardiomyocytes establish circadian rhythmicity in the absence of a sys",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":12,"year":13,"amount":14,"abstract":45},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-028","Mutational signatures of non‐homologous and polymerase theta‐mediated end‐joining in embryonic stem cells","Marcel Tijsterman","Leiden University Medical Center","Abstract Cells employ potentially mutagenic DNA repair mechanisms to avoid the detrimental effects of chromosome breaks on cell survival. While classical non‐homologous end‐joining (cNHEJ) is largely error‐free, alternative end‐joining pathways have been described that are intrinsically mutagenic. Which end‐joining mechanisms operate in germ and embryonic cells and thus contribute to heritable mutations found in congenital diseases is, however, still largely elusive. Here, we determined the gene",{"id":47,"funder":7,"programme":8,"title":48,"piName":49,"institution":38,"country":12,"year":13,"amount":14,"abstract":50},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-91610121","Increased risk of pneumonia in residents living near poultry farms: does the upper respiratory tract microbiota play a role?","Lidwien A.M. Smit","Air pollution has been shown to increase the susceptibility to community-acquired pneumonia (CAP). Previously, we observed an increased incidence of CAP in adults living within 1 km from poultry farms, potentially related to particulate matter and endotoxin emissions. We aim to confirm the increased risk of CAP near poultry farms by refined spatial analyses, and we hypothesize that the oropharyngeal microbiota composition in CAP patients may be associated with residential proximity to poultry fa",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":38,"country":12,"year":13,"amount":14,"abstract":55},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-030","A Phytochrome-Derived Photoswitch for Intracellular Transport","Lukas C. Kapitein","Cells depend on the proper positioning of their organelles, suggesting that active manipulation of organelle positions can be used to explore spatial cell biology and to restore cellular defects caused by organelle misplacement. Recently, blue-light dependent recruitment of specific motors to selected organelles has been shown to alter organelle motility and positioning, but these approaches lack rapid and active reversibility. The light-dependent interaction of phytochrome B with its interactin",{"id":57,"funder":7,"programme":8,"title":58,"piName":59,"institution":26,"country":12,"year":13,"amount":14,"abstract":60},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-275-78-001","Unzipping Zipf’s law","Sander Lestrade","In spite of decades of theorizing, the origins of Zipf's law remain elusive. I propose that a Zipfian distribution straightforwardly follows from the interaction of syntax (word classes differing in class size) and semantics (words having to be sufficiently specific to be distinctive and sufficiently general to be reusable). These factors are independently motivated and well-established ingredients of a natural-language system. Using a computational model, it is shown that neither of these ingre",{"id":62,"funder":7,"programme":8,"title":63,"piName":64,"institution":44,"country":12,"year":13,"amount":14,"abstract":65},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-146-079","The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate","Anke M. Smits","Since the regenerative capacity of the adult mammalian heart is limited, cardiac injury leads to the formation of scar tissue and thereby increases the risk of developing compensatory heart failure. Stem cell therapy is a promising therapeutic approach but is facing problems with engraftment and clinical feasibility. Targeting an endogenous stem cell population could circumvent these limitations. The epicardium, a membranous layer covering the outside of the myocardium, is an accessible cell pop",{"id":67,"funder":7,"programme":8,"title":68,"piName":69,"institution":70,"country":12,"year":13,"amount":14,"abstract":71},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-154-003","Iconicity and Sign Lexical Acquisition: A Review","Gerardo Ortega","Max Planck Institute for Psycholinguistics","The study of iconicity, defined as the direct relationship between a linguistic form and its referent, has gained momentum in recent years across a wide range of disciplines. In the spoken modality, there is abundant evidence showing that iconicity is a key factor that facilitates language acquisition. However, when we look at sign languages, which excel in the prevalence of iconic structures, there is a more mixed picture, with some studies showing a positive effect and others showing a null or",{"id":73,"funder":7,"programme":8,"title":74,"piName":75,"institution":14,"country":14,"year":13,"amount":14,"abstract":76},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-916-14-099","RV pressure overload: from hypertrophy to failure","Frances S. de Man","In pulmonary arterial hypertension (PAH), right ventricular (RV) adaptation is essential to overcome the chronic increases in RV pressure overload. Ultimately, RV compensatory mechanisms are not sufficient and patients succumb to RV failure. The processes underlying the transition of RV adaptation to RV failure are not well understood. In this review, we propose that important insights in RV adaptation processes can be obtained by comparing different etiologies of PAH, namely patients with PAH s",{"id":78,"funder":7,"programme":8,"title":79,"piName":80,"institution":11,"country":12,"year":13,"amount":14,"abstract":81},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-fellowship-863-13-017-","Adult sex ratios and their implications for cooperative breeding in birds","Jan Komdeur","Cooperative breeding is a form of breeding system where in addition to a core breeding pair, one or more usually non-breeding individuals provide offspring care. Cooperative breeding is widespread in birds, but its origin and maintenance in contemporary populations are debated. Although deviations in adult sex ratio (ASR, the proportion of males in the adult population) have been hypothesized to influence the occurrence of cooperative breeding because of the resulting surplus of one sex and limi",{"id":83,"funder":7,"programme":8,"title":84,"piName":85,"institution":86,"country":87,"year":13,"amount":14,"abstract":88},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-158-028","A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human‐type receptors","Robert P. de Vries","Scripps Research Institute","US","In June 2013, the first case of human infection with an avian H6N1 virus was reported in a Taiwanese woman. Although this was a single non-fatal case, the virus continues to circulate in Taiwanese poultry. As with any emerging avian virus that infects humans, there is concern that acquisition of human-type receptor specificity could enable transmission in the human population. Despite mutations in the receptor-binding pocket of the human H6N1 isolate, it has retained avian-type (NeuAcα2-3Gal) re",{"id":90,"funder":7,"programme":8,"title":91,"piName":92,"institution":93,"country":94,"year":13,"amount":14,"abstract":95},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-14-027","Beyond the Status Quo: A Role for Beta Oscillations in Endogenous Content (Re)Activation","Bernhard Spitzer","University of Oxford","GB","Among the rhythms of the brain, oscillations in the beta frequency range (∼13-30 Hz) have been considered the most enigmatic. Traditionally associated with sensorimotor functions, beta oscillations have recently become more broadly implicated in top-down processing, long-range communication, and preservation of the current brain state. Here, we extend and refine these views based on accumulating new findings of content-specific beta-synchronization during endogenous information processing in wor",{"id":97,"funder":7,"programme":8,"title":98,"piName":99,"institution":38,"country":12,"year":13,"amount":14,"abstract":100},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-680-47-432","Diffusion and interactions of point defects in hard-sphere crystals","Berend van der Meer","Using computer simulations, we study the diffusion, interactions, and strain fields of point defects in a face-centered-cubic crystal of hard spheres. We show that the vacancy diffusion decreases rapidly as the density is increased, while the interstitial diffusion exhibits a much weaker density-dependence. Additionally, we predict the free-energy barriers associated with vacancy hopping and find that the increasing height of the free-energy barrier is solely responsible for the slowing down of ",{"id":102,"funder":7,"programme":8,"title":103,"piName":104,"institution":11,"country":12,"year":13,"amount":14,"abstract":105},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-863-11-019","Glucose limitation in \u003Ci>Lactococcus\u003C\u002Fi> shapes a single-peaked fitness landscape exposing membrane occupancy as a constraint","Claire E. Price","ABSTRACT A central theme in biology is to understand the molecular basis of fitness: which strategies succeed under which conditions; how are they mechanistically implemented; and which constraints shape trade-offs between alternative strategies. We approached these questions with parallel bacterial evolution experiments in chemostats. Chemostats provide a constant environment with a defined resource limitation (glucose), in which the growth rate can be controlled. Using Lactococcus lactis , we ",{"id":107,"funder":7,"programme":8,"title":108,"piName":109,"institution":110,"country":12,"year":13,"amount":14,"abstract":111},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-13-004","Divergent regulation of Arabidopsis SAUR genes: a focus on the SAUR10-clade","Hilda van Mourik","Wageningen University & Research","SAUR10-clade genes generally induce cell-elongation, but exhibit diverse expression patterns and responses to hormones. Our experimental and in silico analyses suggest that transcription factors involved in plant development determine the tissue specific expression of the different SAUR genes, whereas the amplitude of this expression can often be controlled by hormone response transcription factors. This allows the plant to fine tune growth in a variety of tissues in response to internal and ext",{"id":113,"funder":7,"programme":8,"title":114,"piName":115,"institution":26,"country":12,"year":13,"amount":14,"abstract":116},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-916-12-140","NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity","René J.M. Bindels","Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after internalization into multivesicular bodies. Human studies indicate that CNIs also increase NCC abundance in uEVs, but results are conflicting and no relationship with NCC function has been shown. Therefo",{"id":118,"funder":7,"programme":8,"title":119,"piName":120,"institution":121,"country":12,"year":13,"amount":14,"abstract":122},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-grant-275-89-020","The Effects of Metaphorical Framing on Political Persuasion: A Systematic Literature Review","Amber Boeynaems","Vrije Universiteit Amsterdam","Effects of metaphorical framing of political issues on opinion have been studied widely by two approaches: a critical-discourse approach (CDA) and a response-elicitation approach (REA). The current article reports a systematic literature review (N = 109) that examines whether these approaches report converging or diverging effects. We compared CDA and REA on the metaphorical frames that were studied and their reported effects. Results show that the CDA frames are typically more negative, nonfict",{"id":124,"funder":7,"programme":8,"title":125,"piName":126,"institution":20,"country":12,"year":13,"amount":14,"abstract":127},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-016-135-135","Can the experimental study of religion be advanced using a Bayesian predictive framework?","Michiel van Elk","We propose a Bayesian framework as an important theoretical and methodological tool to improve the scientific study of religion. At a theoretical level, the Bayesian predictive processing framework has the potential to provide a unifying account of religious beliefs and experience by stressing the central role of error monitoring and error correction in belief maintenance. At a methodological level, Bayesian statistics are needed to provide the extraordinary evidence for the extraordinary theore",{"id":129,"funder":7,"programme":8,"title":130,"piName":131,"institution":132,"country":12,"year":13,"amount":14,"abstract":133},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-91616079","Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study","Adela Brahimaj","Erasmus MC","During a follow-up of up to 14.7 years (between April 1, 1997, and Jan 1, 2012) 139 cases of pre-diabetes, 110 cases of T2D and 26 cases of insulin initiation were identified. In age and sex adjusted Cox models, IL13 (HR = 0.78), EN-RAGE (1.30), CFH (1.24), IL18 (1.22) and CRP (1.32) were associated with incident pre-diabetes. IL13 (0.62), IL17 (0.75), EN-RAGE (1.25), complement 3 (1.44), IL18 (1.35), TNFRII (1.27), IL1ra (1.24) and CRP (1.64) were associated with incident T2D. In multivariate m",{"id":135,"funder":7,"programme":8,"title":136,"piName":137,"institution":138,"country":139,"year":13,"amount":14,"abstract":140},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-13-004","The Basolateral Amygdalae and Frontotemporal Network Functions for Threat Perception","Ruud Hortensius","University of Cape Town","ZA","Although the amygdalae play a central role in threat perception and reactions, the direct contributions of the amygdalae to specific aspects of threat perception, from ambiguity resolution to reflexive or deliberate action, remain ill understood in humans. Animal studies show that a detailed understanding requires a focus on the different subnuclei, which is not yet achieved in human research. Given the limits of human imaging methods, the crucial contribution needs to come from individuals with",{"id":142,"funder":7,"programme":8,"title":143,"piName":144,"institution":145,"country":146,"year":13,"amount":14,"abstract":147},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-grant-722-012-003","Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy","Martin D. Witte","Indian Institute of Chemical Biology","IN","A method for identifying probe modification of proteins via tandem mass spectrometry was developed. Azide bearing molecules are immobilized on functionalised sepharose beads via copper catalysed Huisgen-type click chemistry and selectively released under acidic conditions by chemical cleavage of the triazene linkage. We applied this method to identify the modification site of targeted-diazotransfer on BirA.",{"id":149,"funder":7,"programme":8,"title":150,"piName":151,"institution":11,"country":12,"year":13,"amount":14,"abstract":152},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-fellowship-563-14-003","High‐throughput CRISPRi phenotyping identifies new essential genes in \u003Ci>Streptococcus pneumoniae\u003C\u002Fi>","Xue Liu","Genome-wide screens have discovered a large set of essential genes in the opportunistic human pathogen Streptococcus pneumoniae. However, the functions of many essential genes are still unknown, hampering vaccine development and drug discovery. Based on results from transposon sequencing (Tn-seq), we refined the list of essential genes in S. pneumoniae serotype 2 strain D39. Next, we created a knockdown library targeting 348 potentially essential genes by CRISPR interference (CRISPRi) and show a",{"id":154,"funder":7,"programme":8,"title":155,"piName":156,"institution":157,"country":12,"year":13,"amount":14,"abstract":158},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-722-013-014","Dissociative ionisation of adamantane: a combined theoretical and experimental study","Alessandra Candian","Leiden University","Diamond nanoparticles, or nanodiamonds, are intriguing carbon-based materials which, maybe surprisingly, are the most abundant constituent of presolar grains. While the spectroscopic properties of even quite large diamondoids have already been explored, little is known about their unimolecular fragmentation processes. In this paper we characterise the dissociative ionisation of adamantane (C\u003Csub>10\u003C\u002Fsub>H\u003Csub>16\u003C\u002Fsub>) - the smallest member of the diamondoid family - utilising imaging Photoelect",{"id":160,"funder":7,"programme":8,"title":155,"piName":156,"institution":157,"country":12,"year":13,"amount":14,"abstract":158},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-639-041-543",{"id":162,"funder":7,"programme":8,"title":163,"piName":164,"institution":26,"country":12,"year":13,"amount":14,"abstract":165},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-10-017","Bayesian adaptive stimulus selection for dissociating models of psychophysical data","James R. H. Cooke","Abstract Comparing models facilitates testing different hypotheses regarding the computational basis of perception and action. Effective model comparison requires stimuli for which models make different predictions. Typically, experiments use a predetermined set of stimuli or sample stimuli randomly. Both methods have limitations; a predetermined set may not contain stimuli that dissociate the models whereas random sampling may be inefficient. To overcome these limitations, we expanded the psi-a",{"id":167,"funder":7,"programme":8,"title":168,"piName":169,"institution":170,"country":171,"year":13,"amount":14,"abstract":172},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw016-veni-171-097","Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy","Katharina N. Richter","Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103","DE","Paraformaldehyde (PFA) is the most commonly used fixative for immunostaining of cells, but has been associated with various problems, ranging from loss of antigenicity to changes in morphology during fixation. We show here that the small dialdehyde glyoxal can successfully replace PFA Despite being less toxic than PFA, and, as most aldehydes, likely usable as a fixative, glyoxal has not yet been systematically tried in modern fluorescence microscopy. Here, we tested and optimized glyoxal fixatio",{"id":174,"funder":7,"programme":8,"title":175,"piName":176,"institution":177,"country":87,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-15-012","Encoding of natural timbre dimensions in human auditory cortex","Emily Allen","University of Minnesota",{"id":179,"funder":7,"programme":8,"title":180,"piName":181,"institution":182,"country":183,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-087","Review: Host-pathogen dynamics of seagrass diseases under future global change","Brooke K. Sullivan","The University of Melbourne","AU",{"id":185,"funder":7,"programme":8,"title":186,"piName":187,"institution":157,"country":12,"year":13,"amount":14,"abstract":188},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-155-082","The role of pupil size in communication. Is there room for learning?","Mariska E. Kret","The eyes are extremely important for communication. The muscles around the eyes express emotional states and the size of the pupil signals whether a person is aroused and alert or bored and fatigued. Pupil size is an overlooked social signal, yet is readily picked up by observers. Observers mirror their own pupil sizes in response, which can influence social impressions. In a landmark study by Hess [1975. The role of pupil size in communication. Scientific American, 233(5), 110-119] it was shown",{"id":190,"funder":7,"programme":8,"title":191,"piName":192,"institution":38,"country":12,"year":13,"amount":14,"abstract":193},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-722-014-005","Performance of HADDOCK and a simple contact-based protein–ligand binding affinity predictor in the D3R Grand Challenge 2","Zeynep Kurkcuoglu","We present the performance of HADDOCK, our information-driven docking software, in the second edition of the D3R Grand Challenge. In this blind experiment, participants were requested to predict the structures and binding affinities of complexes between the Farnesoid X nuclear receptor and 102 different ligands. The models obtained in Stage1 with HADDOCK and ligand-specific protocol show an average ligand RMSD of 5.1 Å from the crystal structure. Only 6\u002F35 targets were within 2.5 Å RMSD from the",{"id":195,"funder":7,"programme":8,"title":196,"piName":197,"institution":198,"country":12,"year":13,"amount":14,"abstract":199},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-fellowship-grant-number-916-10-156-","The acute effect of beta‐guanidinopropionic acid \u003Ci>versus\u003C\u002Fi> creatine or placebo in healthy men (ABC‐Trial): A randomized controlled first‐in‐human trial","Fares A. Karamat","Amsterdam UMC Location University of Amsterdam","In this first-in-human trial, low-dose GPA was safe and well-tolerated when used during 1 week in healthy men. Subsequent studies should focus on human pharmacokinetic and pharmacodynamic assessments with different doses.",34,{"programme":8,"total":202,"withPiName":202,"firstYear":203,"lastYear":204,"countryCount":205,"perYear":206,"topInstitutions":251,"topCountries":305},779,1999,2026,32,[207,209,212,215,218,221,224,225,228,231,234,237,240,243,246,249],{"year":203,"count":208},3,{"year":210,"count":211},2011,2,{"year":213,"count":214},2013,4,{"year":216,"count":217},2014,5,{"year":219,"count":220},2015,14,{"year":222,"count":223},2016,26,{"year":13,"count":200},{"year":226,"count":227},2018,80,{"year":229,"count":230},2019,27,{"year":232,"count":233},2020,42,{"year":235,"count":236},2021,51,{"year":238,"count":239},2022,56,{"year":241,"count":242},2023,103,{"year":244,"count":245},2024,110,{"year":247,"count":248},2025,139,{"year":204,"count":250},83,[252,254,256,257,259,260,261,263,266,269,271,274,276,279,280,282,285,288,290,293,295,297,299,301,303],{"name":38,"count":253},76,{"name":26,"count":255},58,{"name":11,"count":236},{"name":157,"count":258},40,{"name":20,"count":258},{"name":110,"count":230},{"name":121,"count":262},24,{"name":264,"count":265},"Delft University of Technology",23,{"name":267,"count":268},"Eindhoven University of Technology",17,{"name":270,"count":268},"University of Twente",{"name":272,"count":273},"University Medical Center Groningen",15,{"name":132,"count":275},13,{"name":277,"count":278},"Amsterdam University Medical Centers",10,{"name":44,"count":278},{"name":281,"count":278},"Tilburg University",{"name":283,"count":284},"Erasmus University Rotterdam",9,{"name":286,"count":287},"Amsterdam Neuroscience",8,{"name":32,"count":289},7,{"name":291,"count":292},"Centre National de la Recherche Scientifique",6,{"name":294,"count":292},"Royal Netherlands Institute for Sea Research",{"name":296,"count":292},"University of Copenhagen",{"name":298,"count":217},"Amsterdam University of Applied Sciences",{"name":300,"count":217},"Institute for Atomic and Molecular Physics",{"name":302,"count":217},"Maastricht University",{"name":304,"count":217},"Maastricht University Medical Centre",[306,308,309,311,313,316,318,320,322,324,325,327,329,331,333,335,336,338,340,342,344,345,348,350,352],{"name":12,"count":307},551,{"name":87,"count":223},{"name":171,"count":310},19,{"name":94,"count":312},18,{"name":314,"count":315},"FR",12,{"name":317,"count":284},"DK",{"name":319,"count":287},"IT",{"name":321,"count":289},"CZ",{"name":323,"count":292},"AT",{"name":183,"count":292},{"name":326,"count":292},"BE",{"name":328,"count":292},"ES",{"name":330,"count":217},"CA",{"name":332,"count":217},"CN",{"name":334,"count":217},"PL",{"name":139,"count":217},{"name":337,"count":214},"NO",{"name":339,"count":208},"SE",{"name":341,"count":211},"CH",{"name":343,"count":211},"FI",{"name":146,"count":211},{"name":346,"count":347},"JP",1,{"name":349,"count":347},"KR",{"name":351,"count":347},"LK",{"name":353,"count":347},"MK"]