[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-veni-2018":3,"awarded-stats-nwo-veni":422},{"awarded":4,"total":421},[5,16,21,27,34,40,46,51,57,62,69,75,81,87,93,99,105,111,116,122,126,132,139,144,150,156,161,166,171,176,183,189,194,200,206,211,216,221,226,233,235,240,247,252,254,256,258,263,268,272,277,282,287,289,295,300,305,310,315,321,325,331,336,341,346,351,358,363,368,374,381,386,392,394,400,404,409,415,417,419],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-030","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Veni","Evolutionary significance of the microbial assemblages of large benthic Foraminifera","Martina Prazeres","Naturalis Biodiversity Center","NL",2018,null,"Large benthic Foraminifera (LBF) are major carbonate producers on coral reefs, and are hosts to a diverse symbiotic microbial community. During warm episodes in the geological past, these reef-building organisms expanded their geographical ranges as subtropical and tropical belts moved into higher latitudes. During these range-expansion periods, LBF were the most prolific carbonate producers on reefs, dominating shallow carbonate platforms over reef-building corals. Even though the fossil and mo",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-16-025","Economies of scale in recoverable robust maintenance location routing for rolling stock","Denise Tönissen","Vrije Universiteit Amsterdam",{"id":22,"funder":7,"programme":8,"title":23,"piName":24,"institution":25,"country":12,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-112","Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice","Marit J. van Gils","Amsterdam University Medical Centers","Broadly neutralizing antibodies (bNAbs) such as PGDM1400 show promise as prophylactic and therapeutic agents against HIV-1. Human immune system mice were passively immunized with different doses of PGDM1400 and challenged 24 h later with a high dose of HIV-1JRCSF. We found that PGDM1400 provided protection against HIV-1 challenge in a concentration dependent manner and that the protective concentration in blood was ∼75-fold higher than the in vitro 50% inhibitory concentration. The results demon",{"id":28,"funder":7,"programme":8,"title":29,"piName":30,"institution":31,"country":32,"year":13,"amount":14,"abstract":33},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-15-010","Dynamic models of choice","Andrew Heathcote","University of Tasmania","AU","Parameter estimation in evidence-accumulation models of choice response times is demanding of both the data and the user. We outline how to fit evidence-accumulation models using the flexible, open-source, R-based Dynamic Models of Choice (DMC) software. DMC provides a hands-on introduction to the Bayesian implementation of two popular evidence-accumulation models: the diffusion decision model (DDM) and the linear ballistic accumulator (LBA). It enables individual and hierarchical estimation, as",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-148-002","Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients","Erwin Krikken","University Medical Center Utrecht","BACKGROUND: The purpose of this work was to investigate noninvasive early detection of treatment response of breast cancer patients to neoadjuvant chemotherapy (NAC) using chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) at 7 T. METHODS: CEST images were acquired in 10 tumors of nine breast cancer patients treated with NAC. APT signals in the tumor, before and after the first cycle of NAC, were quantified using a three-pool Lorentzian fit of the ",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":12,"year":13,"amount":14,"abstract":45},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-916-12-056","RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr−\u002F− mice","Kristiaan Wouters","Maastricht University Medical Centre","Abstract Non-alcoholic fatty liver disease is a spectrum of liver diseases ranging from steatosis only to non-alcoholic steatohepatitis (NASH). The latter is characterized by hepatic inflammation, which increases the risk of cardiovascular disease. It is poorly understood which factors contribute to the onset of hepatic inflammation characterizing the progression from steatosis to NASH. Previously, we demonstrated increased advanced glycation endproducts (AGEs) in the livers of NASH patients. We",{"id":47,"funder":7,"programme":8,"title":48,"piName":49,"institution":11,"country":12,"year":13,"amount":14,"abstract":50},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-041","Changing invaders: trends of gigantism in insular introduced rats","Alexandra van der Geer","SUMMARY The degree and direction of morphological change in invasive species with a long history of introduction are insufficiently known for a larger scale than the archipelago or island group. Here, I analyse data for 105 island populations of Polynesian rats, Rattus exulans , covering the entirety of Oceania and Wallacea to test whether body size differs in insular populations and, if so, what biotic and abiotic features are correlated with it. All insular populations of this rat, except one,",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":55,"country":12,"year":13,"amount":14,"abstract":56},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-12-039","Pupil Responses of Adults With Traumatic Brain Injury During Processing of Speech in Noise","Thomas Koelewijn","Amsterdam Neuroscience","Previous research has shown the effects of task demands on pupil responses in both normal hearing (NH) and hearing impaired (HI) adults. One consistent finding is that HI listeners have smaller pupil dilations at low levels of speech recognition performance (≤50%). This study aimed to examine the pupil dilation in adults with a normal pure-tone audiogram who experience serious difficulties when processing speech-in-noise. Hence, 20 adults, aged 26 to 62 years, with traumatic brain injury (TBI) o",{"id":58,"funder":7,"programme":8,"title":59,"piName":60,"institution":55,"country":12,"year":13,"amount":14,"abstract":61},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-15-015","Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments","Maël Lebreton","Decisions are accompanied by a feeling of confidence, that is, a belief about the decision being correct. Confidence accuracy is critical, notably in high-stakes situations such as medical or financial decision-making. We investigated how incentive motivation influences confidence accuracy by combining a perceptual task with a confidence incentivization mechanism. By varying the magnitude and valence (gains or losses) of monetary incentives, we orthogonalized their motivational and affective com",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":66,"country":67,"year":13,"amount":14,"abstract":68},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-14-015","The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study","David Terburg","University of Cape Town","ZA","responses in BLA-silenced rats. Our data reveal how the BLA, via the CeA, adaptively regulates escape behavior from imminent threat and that this mechanism is evolutionary conserved across rodents and humans.",{"id":70,"funder":7,"programme":8,"title":71,"piName":72,"institution":73,"country":12,"year":13,"amount":14,"abstract":74},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-13681-fc-","Centrifugation affects the purity of liquid biopsy‐based tumor biomarkers","Linda G. Rikkert","University of Twente","Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. The model is",{"id":76,"funder":7,"programme":8,"title":77,"piName":78,"institution":79,"country":12,"year":13,"amount":14,"abstract":80},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-09-006","Action perception recruits the cerebellum and is impaired in spinocerebellar ataxia patients","Abdel R. Abdelgabar","Netherlands Institute for Neuroscience","Abstract Our cerebellum has been proposed to generate prediction signals that may help us plan and execute our motor programs. However, to what extent our cerebellum is also actively involved in perceiving the action of others remains to be elucidated. Using fMRI, we show here that observing goal-directed hand actions of others bilaterally recruits cerebellar Lobules VI, VIIb and VIIIa. Moreover, whereas healthy subjects (n=31) were found to be able to discriminate subtle differences in the kine",{"id":82,"funder":7,"programme":8,"title":83,"piName":84,"institution":85,"country":12,"year":13,"amount":14,"abstract":86},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-063","Modeling water quality in the Anthropocene: directions for the next-generation aquatic ecosystem models","Wolf M. Mooij","Netherlands Institute of Ecology","“Everything changes and nothing stands still” (Heraclitus). Here we review three major improvements to freshwater aquatic ecosystem models — and ecological models in general — as water quality scenario analysis tools towards a sustainable future. To tackle the rapid and deeply connected dynamics characteristic of the Anthropocene, we argue for the inclusion of eco-evolutionary, novel ecosystem and social-ecological dynamics. These dynamics arise from adaptive responses in organisms and ecosystem",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":12,"year":13,"amount":14,"abstract":92},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-863-14-019","The draft genome sequence of “Nitrospira lenta” strain BS10, a nitrite oxidizing bacterium isolated from activated sludge","Dimitra Sakoula","Radboud University Nijmegen","The genus \u003Ci>Nitrospira\u003C\u002Fi> is considered to be the most widespread and abundant group of nitrite-oxidizing bacteria in many natural and man-made ecosystems. However, the ecophysiological versatility within this phylogenetic group remains highly understudied, mainly due to the lack of pure cultures and genomic data. To further expand our understanding of this biotechnologically important genus, we analyzed the high quality draft genome of \"\u003Ci>Nitrospira lenta\u003C\u002Fi>\" strain BS10, a sublineage II \u003Ci",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":97,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-17-005-to-m-d-","Partners’ adjustment to older workers’ retirement: testing the role of preretirement expectations in a 10-year panel study","Marleen Damman","University Medical Center Groningen","\u003Cb>Objectives:\u003C\u002Fb> Retirement is not only an important later-life transition for the retiring individual, but also for his or her life partner. This study aims to improve our understanding of the partner's adjustment to the retirement of the older worker, by paying attention to the multidimensional nature of adjustment, and by examining to what extent preretirement expectations are predictive of postretirement experiences. Well-established adjustment predictors - i.e. preretirement resources and",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":103,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-092","CRISPR-based DNA and RNA detection with liquid-liquid phase separation","Stan J. J. Brouns","Wageningen University & Research","Abstract The ability to detect specific nucleic acid sequences allows for a wide range of applications including identification of pathogens, clinical diagnostics, and genotyping. CRISPR-Cas proteins Cas12a and Cas13a are RNA-guided endonucleases that bind and cleave specific DNA and RNA sequences, respectively. After recognition of a target sequence both enzymes activate a unique, indiscriminate nucleic acid cleavage activity, which has been exploited for detection of sequence specific nucleoti",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":109,"country":12,"year":13,"amount":14,"abstract":110},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-14-004","Do consistent government policies lead to greater meaningfulness and legitimacy on the front line?","Nadine van Engen","Erasmus University Rotterdam","We investigate the impact of policy consistency on frontline workers’ perceptions of policy meaningfulness and legitimacy. The results from an experiment involving 779 teachers indicate that policy consistency does have a positive effect on legitimacy and to a lesser extent on meaningfulness. However, the extent depends on policy content and the degree of autonomy. Overall, our findings emphasize the potential positive impact of policy consistency. Although this, to some extent, conflicts with t",{"id":112,"funder":7,"programme":8,"title":113,"piName":114,"institution":73,"country":12,"year":13,"amount":14,"abstract":115},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-15872","Fourier conjugate adaptive optics for deep-tissue large field of view imaging","Lyubov V. Amitonova","Light microscopy enables multifunctional imaging of biological specimens at unprecedented depths and resolutions. However, the performance of all optical methods degrades with the imaging depth due to sample-induced aberrations. Methods of adaptive optics (AO), which are aimed at pre-compensation of these distortions, still suffer from a limited field of view and imaging depth as well as inconvenient microscope design. Here, I propose and investigate a new approach to overcome these limitations:",{"id":117,"funder":7,"programme":8,"title":118,"piName":119,"institution":120,"country":12,"year":13,"amount":14,"abstract":121},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-15-003","A low-cost device for measuring local magnetic anomalies in volcanic terrain","Bertwin M. de Groot","Utrecht University","Abstract. Reconstructions of the past behavior of the geomagnetic field critically depend on the magnetic signal stored in extrusive igneous rocks. These rocks record the Earth's magnetic field when they cool and retain this magnetization on geological time scales. In rugged volcanic terrain, however, the magnetic signal arising from the underlying flows may influence the ambient magnetic field as recorded by newly formed flows on top. To measure these local anomalies in the Earth's magnetic fie",{"id":123,"funder":7,"programme":8,"title":124,"piName":125,"institution":120,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-078","Protists: Puppet Masters of the Rhizosphere Microbiome","Zhilei Gao",{"id":127,"funder":7,"programme":8,"title":128,"piName":129,"institution":130,"country":12,"year":13,"amount":14,"abstract":131},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-186-012","Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+","Steef Kurstjens","Radboud University Medical Center","This study shows that elevated NEFA and triacylglycerol levels directly reduce blood Mg\u003Csup>2+\u003C\u002Fsup> levels, in part explaining the high prevalence of hypomagnesaemia in metabolic disorders. We show that blood NEFA level affects the free Mg\u003Csup>2+\u003C\u002Fsup> concentration, and therefore, our data challenge how the fractional excretion of Mg\u003Csup>2+\u003C\u002Fsup> is calculated and interpreted in the clinic.",{"id":133,"funder":7,"programme":8,"title":134,"piName":135,"institution":136,"country":137,"year":13,"amount":14,"abstract":138},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-172-034","The Nature and Catalytic Function of Cation Sites in Zeolites: a Computational Perspective","Evgeny A. Pidko","ITMO University","RU","Abstract Zeolites have a broad spectrum of applications as robust microporous catalysts for various chemical transformations. The reactivity of zeolite catalysts can be tailored by introducing heteroatoms either into the framework or at the extraframework positions that gives rise to the formation of versatile Brønsted acid, Lewis acid and redox‐active catalytic sites. Understanding the nature and catalytic role of such sites is crucial for guiding the design of new and improved zeolite‐based ca",{"id":140,"funder":7,"programme":8,"title":141,"piName":142,"institution":120,"country":12,"year":13,"amount":14,"abstract":143},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-049","Development and Evaluation of a Pan-European Multimodel Seasonal Hydrological Forecasting System","Niko Wanders","Abstract Hydrological forecasts with a high temporal and spatial resolution are required to provide the level of information needed by end users. So far high-resolution multimodel seasonal hydrological forecasts have been unavailable due to 1) lack of availability of high-resolution meteorological seasonal forecasts, requiring temporal and spatial downscaling; 2) a mismatch between the provided seasonal forecast information and the user needs; and 3) lack of consistency between the hydrological ",{"id":145,"funder":7,"programme":8,"title":146,"piName":147,"institution":148,"country":12,"year":13,"amount":14,"abstract":149},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-16-001","Cross-Level Invariance in Multilevel Factor Models","Suzanne Jak","University of Amsterdam","When modeling latent variables at multiple levels, it is important to consider the meaning of the latent variables at the different levels. If a higher-level common factor represents the aggregated version of a lower-level factor, the associated factor loadings will be equal across levels. However, many researchers do not consider cross-level invariance constraints in their research. Not applying these constraints when in fact they are appropriate leads to overparameterized models, and associate",{"id":151,"funder":7,"programme":8,"title":152,"piName":153,"institution":154,"country":12,"year":13,"amount":14,"abstract":155},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-talent-scheme-veni-grant-no-451-15-039","Discrete Choice Experiments in Health Economics: Past, Present and Future","Vikas Soekhai","Erasmus MC","The use of empirical DCEs in health economics continues to grow. However, inadequate reporting of methodological details inhibits quality assessment. This may reduce decision-makers' confidence in results and their ability to act on the findings. How and when to integrate health-related DCE outcomes into decision-making remains an important area for future research.",{"id":157,"funder":7,"programme":8,"title":158,"piName":159,"institution":120,"country":12,"year":13,"amount":14,"abstract":160},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-project-722-013-009-","The Influence of Metabolism on Drug Response in Cancer","Celia R. Berkers","Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in the treatment of cancers and occurs in virtually every type of anti-cancer therapy. Therefore, understanding how resistance can be prevented, targeted and predicted becomes increasingly important to improve cancer therapy. In the last decade, it has become apparent that alterations in cellular metabolism are a hallmark of cancer cells and that a rewired metabolism is essential for rapid tumor growth a",{"id":162,"funder":7,"programme":8,"title":163,"piName":164,"institution":91,"country":12,"year":13,"amount":14,"abstract":165},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-166-089","Bacterial Zombies and Ghosts: Production of Inactivated Gram-Positive and Gram-Negative Species with Preserved Cellular Morphology and Cytoplasmic Content","Annemarie Boleij","ABSTRACT There are many approaches available to inactivate bacteria, each with a different efficacy, impact on cell integrity, and potential for application in high-throughput. The aim of this study was to compare these approaches and develop a standardized protocol for generation of intact Gram-positive as well as on Gram-negative “bacterial zombies”, i.e. cells that are metabolically dead with retained cellular integrity. Here, we introduce the term “bacterial zombies” in addition to “bacteria",{"id":167,"funder":7,"programme":8,"title":168,"piName":169,"institution":120,"country":12,"year":13,"amount":14,"abstract":170},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-016-168-038","A systematic review on the quantitative relationship between structural and functional network connectivity strength in mammalian brains","Milou Straathof","The mammalian brain is composed of densely connected and interacting regions, which form structural and functional networks. An improved understanding of the structure-function relation is crucial to understand the structural underpinnings of brain function and brain plasticity after injury. It is currently unclear how functional connectivity strength relates to structural connectivity strength. We obtained an overview of recent papers that report on correspondences between quantitative function",{"id":172,"funder":7,"programme":8,"title":173,"piName":174,"institution":91,"country":12,"year":13,"amount":14,"abstract":175},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-016-171-068","Genetic influence on contrast sensitivity in young adults","Koen V. Haak","Contrast sensitivity, the ability to detect small luminance differences, is an important independent aspect of visual function that can vary more than fourfold across normal individuals (Baker 2013). Little is known about the degree to which this variation is determined by genetic and environmental factors. The only study to date was based on a sample of male military veterans with an age range of 52–60, and estimated the heritability of contrast sensitivity (i.e., the portion of phenotypic vari",{"id":177,"funder":7,"programme":8,"title":178,"piName":179,"institution":180,"country":181,"year":13,"amount":14,"abstract":182},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-13047","Small RNA molecules and their role in plant disease","Laura Rose","Heinrich Heine University Düsseldorf","DE","All plant species are subject to disease. Plant diseases are caused by parasites, e.g. viruses, bacteria, oomycetes, parasitic plants, fungi, or nematodes. In all organisms, gene expression is tightly regulated and underpins essential functions and physiology. The coordination and regulation of both host and pathogen gene expression is essential for pathogens to infect and cause disease. One mode of gene regulation is RNA silencing. This biological process is widespread in the natural world, pre",{"id":184,"funder":7,"programme":8,"title":185,"piName":186,"institution":187,"country":12,"year":13,"amount":14,"abstract":188},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-188-049","Sensorimotor Manipulations of the Balance Control Loop–Beyond Imposed External Perturbations","Patrick A. Forbes","Delft University of Technology","Standing balance relies on the integration of multiple sensory inputs to generate the motor commands required to stand. Mechanical and sensory perturbations elicit compensatory postural responses that are interpreted as a window into the sensorimotor processing involved in balance control. Popular methods involve imposed external perturbations that disrupt the control of quiet stance. Although these approaches provide critical information on how the balance system responds to external disturbanc",{"id":190,"funder":7,"programme":8,"title":191,"piName":192,"institution":103,"country":12,"year":13,"amount":14,"abstract":193},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-863-14-007","Carrying a logger reduces escape flight speed in a passerine bird, but relative logger mass may be a misleading measure of this flight performance detriment","Florian T. Muijres","Abstract The recent boost in bird migration studies following the development of various tracking devices raised awareness of how detrimental attaching devices can be for animals. Such effects can occur during migration, but also immediately post‐release if the device impairs escape flight performance and, consequently, the bird's ability to evade predators. In this study, we investigated the effect of carrying a device on the escape flight speed and aerodynamic force production in a migratory p",{"id":195,"funder":7,"programme":8,"title":196,"piName":197,"institution":198,"country":12,"year":13,"amount":14,"abstract":199},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-016-136-125","Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study","Maxime M. Bos","Leiden University Medical Center","Short and long sleep duration and poor sleep quality may affect serum and hepatic lipid content, but available evidence is inconsistent. Therefore, we aimed to investigate the associations of sleep duration and quality with serum and hepatic lipid content in a large population-based cohort of middle-aged individuals. The present cross-sectional study was embedded in the Netherlands Epidemiology of Obesity (NEO) study and consisted of 4260 participants (mean age, 55 years; proportion men, 46%) no",{"id":201,"funder":7,"programme":8,"title":202,"piName":203,"institution":204,"country":12,"year":13,"amount":14,"abstract":205},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-275-20-251","Modelling the history of early modern natural philosophy: the fate of the art-nature distinction in the Dutch universities","Andrea Sangiacomo","University of Groningen","The ‘model approach’ facilitates a quantitative-oriented study of conceptual changes in large corpora. This paper implements the ‘model approach’ to investigate the erosion of the traditional art-nature distinction in early modern natural philosophy. I argue that a condition for this transformation has to be located in the late scholastic conception of final causation. I design a conceptual model to capture the art-nature distinction and formulate a working hypothesis about its early modern fate",{"id":207,"funder":7,"programme":8,"title":208,"piName":209,"institution":103,"country":12,"year":13,"amount":14,"abstract":210},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-095","Changes in surface hydrology, soil moisture and gross primary production in the Amazon during the 2015\u002F2016 El Niño","Erik van Schaik","The 2015\u002F2016 El Niño event caused severe changes in precipitation across the tropics. This impacted surface hydrology, such as river run-off and soil moisture availability, thereby triggering reductions in gross primary production (GPP). Many biosphere models lack the detailed hydrological component required to accurately quantify anomalies in surface hydrology and GPP during droughts in tropical regions. Here, we take the novel approach of coupling the biosphere model SiBCASA with the advanced",{"id":212,"funder":7,"programme":8,"title":213,"piName":214,"institution":130,"country":12,"year":13,"amount":14,"abstract":215},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-068","Human V2A: A map of the peripheral visual hemifield with functional connections to scene-selective cortex","Joris A. Elshout","Humans can recognize a scene in the blink of an eye. This gist-based visual scene perception is thought to be underpinned by specialized visual processing emphasizing the visual periphery at a cortical locus relatively low in the visual processing hierarchy. Using wide-field retinotopic mapping and population receptive field (pRF) modeling, we identified a new visual hemifield map anterior of area V2d and inferior to area V6, which we propose to call area V2A. Based on its location relative to o",{"id":217,"funder":7,"programme":8,"title":218,"piName":219,"institution":120,"country":12,"year":13,"amount":14,"abstract":220},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-veni-863-12-001","Local microtubule organization promotes cargo transport in \u003Ci>C. elegans\u003C\u002Fi> dendrites","Martin Harterink","The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal polarity that allows for selective cargo sorting. However, how dendritic microtubules are organized and whether local differences influence cargo transport remains largely unknown. Here, we use live-cell imaging to systematically probe the microtubule organization in \u003Ci>Caenorhabditis\u003C\u002Fi>\u003Ci>elegans\u003C\u002Fi> neurons, and demonstrate the contribution of distin",{"id":222,"funder":7,"programme":8,"title":223,"piName":224,"institution":120,"country":12,"year":13,"amount":14,"abstract":225},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-722-014-005","Large-scale prediction of binding affinity in protein–small ligand complexes: the PRODIGY-LIG web server","Anna Vangone","PRODIGY-LIG is freely available without registration requirements at http:\u002F\u002Fmilou.science.uu.nl\u002Fservices\u002FPRODIGY-LIG.",{"id":227,"funder":7,"programme":8,"title":228,"piName":229,"institution":230,"country":231,"year":13,"amount":14,"abstract":232},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-15-008","Modeling Nonlinear Conditional Dependence Between Response Time and Accuracy","Maria Bolsinova","ACT","US","The most common process variable available for analysis due to tests presented in a computerized form is response time. Psychometric models have been developed for joint modeling of response accuracy and response time in which response time is an additional source of information about ability and about the underlying response processes. While traditional models assume conditional independence between response time and accuracy given ability and speed latent variables (van der Linden, 2007), rece",{"id":234,"funder":7,"programme":8,"title":228,"piName":229,"institution":230,"country":231,"year":13,"amount":14,"abstract":232},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-15-008",{"id":236,"funder":7,"programme":8,"title":237,"piName":238,"institution":97,"country":12,"year":13,"amount":14,"abstract":239},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-916-16025","TPX2\u002FAurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells","Stephanie E. van Gijn","Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests that cancer cells are molecularly \"rewired\" to cope with defective DNA repair and the resulting high levels of genomic instability. In this study, we aim to identify genes that gen",{"id":241,"funder":7,"programme":8,"title":242,"piName":243,"institution":244,"country":245,"year":13,"amount":14,"abstract":246},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-91617140","Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria","Jesmin Lohy Das","Uppsala University","SE","The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related changes on exposure is unclear, and pregnancy has been associated with decreased efficacy in previous studies. This study aimed to characterize the population pharmacokinetics of artemether, its active metabolite dihydroartemisinin, and lumefantrine in 22 Rwandese pregnant women in their second (\u003Ci>n\u003C\u002Fi> = 11) or third (\u003Ci>n\u003C\u002Fi> = 11) trimester",{"id":248,"funder":7,"programme":8,"title":249,"piName":250,"institution":120,"country":12,"year":13,"amount":14,"abstract":251},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-722-012-066","ACBD3 is an essential pan-enterovirus host factor that mediates the interaction between viral 3A protein and cellular protein PI4KB","Frank J. M. van Kuppeveld","Abstract The enterovirus genus of the picornavirus family includes a large number of important human pathogens such as poliovirus, coxsackievirus, enterovirus-A71, and rhinoviruses. Like all other positive-strand RNA viruses, genome replication of enteroviruses occurs on rearranged membranous structures called replication organelles (ROs). Phosphatidylinositol 4-kinase IIIβ (PI4KB) is required by all enteroviruses for RO formation. The enteroviral 3A protein recruits PI4KB to ROs, but the exact ",{"id":253,"funder":7,"programme":8,"title":249,"piName":250,"institution":120,"country":12,"year":13,"amount":14,"abstract":251},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-722-012-066",{"id":255,"funder":7,"programme":8,"title":249,"piName":250,"institution":120,"country":12,"year":13,"amount":14,"abstract":251},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-863-12-005",{"id":257,"funder":7,"programme":8,"title":249,"piName":250,"institution":120,"country":12,"year":13,"amount":14,"abstract":251},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-12-005",{"id":259,"funder":7,"programme":8,"title":260,"piName":261,"institution":187,"country":12,"year":13,"amount":14,"abstract":262},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-15916","Distributed multi-robot formation control in dynamic environments","Javier Alonso–Mora","This paper presents a distributed method for formation control of a homogeneous team of aerial or ground mobile robots navigating in environments with static and dynamic obstacles. Each robot in the team has a finite communication and visibility radius and shares information with its neighbors to coordinate. Our approach leverages both constrained optimization and multi-robot consensus to compute the parameters of the multi-robot formation. This ensures that the robots make progress and avoid co",{"id":264,"funder":7,"programme":8,"title":265,"piName":266,"institution":120,"country":12,"year":13,"amount":14,"abstract":267},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-041","Potential permeability enhancement in Early Jurassic shales due to their swelling and shrinkage behavior","Maartje Houben","The presence of water in mudrocks has a largely negative impact on production of gas stored in these rocks, due to the fact that water causes swelling of the rock. Removing the water from the mudrock could potentially shrink the rock and increase the overall permeability of the rock. Investigation of the swelling\u002Fshrinkage behaviour of the rock during exposure to water vapour is of key importance in designing and optimizing unconventional production strategies. We have used outcrop samples of th",{"id":269,"funder":7,"programme":8,"title":270,"piName":271,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-04-034","Do Parental Psychiatric Symptoms Predict Outcome in Children With Psychiatric Disorders? A Naturalistic Clinical Study","Laura W. Wesseldijk",{"id":273,"funder":7,"programme":8,"title":274,"piName":275,"institution":91,"country":12,"year":13,"amount":14,"abstract":276},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-916-96-021","Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development","Leonie M. Kamminga","Polycomb Group (PcG) genes are transcriptional repressors that are described to be important during development and differentiation. There is significant interest in PcGs proteins because of their role in stem cell biology and tumorigenesis. In this study we characterize the expression of a selection of PcG genes in the adult germline of zebrafish and during embryogenesis. In adults, expression of selected PcG genes is found to be enriched in germ line over somatic tissues. Therefore, the germ l",{"id":278,"funder":7,"programme":8,"title":279,"piName":280,"institution":91,"country":12,"year":13,"amount":14,"abstract":281},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-863-150-25-","Neural Coding With Bursts—Current State and Future Perspectives","Fleur Zeldenrust","Neuronal action potentials or spikes provide a long-range, noise-resistant means of communication between neurons. As point processes single spikes contain little information in themselves, i.e. outside the context of spikes from other neurons. Moreover, they may fail to cross a synapse. A burst, which consists of a short high frequency train of spikes, will more reliably cross a synapse, increasing the likelihood of eliciting a postsynaptic spike, depending on the specific short-term plasticity",{"id":283,"funder":7,"programme":8,"title":284,"piName":285,"institution":73,"country":12,"year":13,"amount":14,"abstract":286},"openalex-nederlandse-organisatie-voor-wetenschapp-award-personal-grant-nb-veni-13615","Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography","Colin Veenstra","Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity through a ",{"id":288,"funder":7,"programme":8,"title":284,"piName":285,"institution":73,"country":12,"year":13,"amount":14,"abstract":286},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-13615",{"id":290,"funder":7,"programme":8,"title":291,"piName":292,"institution":293,"country":181,"year":13,"amount":14,"abstract":294},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-86312012","Impacts of warming on top-down and bottom-up controls of periphyton production","Garabet Kazanjian","Leibniz Institute of Freshwater Ecology and Inland Fisheries","Global warming profoundly impacts the functioning of aquatic ecosystems. Nonetheless, the effect of warming on primary producers is poorly understood, especially periphyton production, which is affected both directly and indirectly by temperature-sensitive top-down and bottom-up controls. Here, we study the impact of warming on gross primary production in experimental ecosystems with near-realistic foodwebs during spring and early summer. We used indoor mesocosms following a temperate temperatur",{"id":296,"funder":7,"programme":8,"title":297,"piName":298,"institution":204,"country":12,"year":13,"amount":14,"abstract":299},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-002","Megaherbivores may impact expansion of invasive seagrass in the Caribbean","Marjolijn J. A. Christianen","Abstract Our knowledge of the functional role of large herbivores is rapidly expanding, and the impact of grazing on species coexistence and nonnative species expansion has been studied across ecosystems. However, experimental data on large grazer impacts on plant invasion in aquatic ecosystems are lacking. Since its introduction in 2002, the seagrass species Halophila stipulacea has rapidly expanded across the Eastern Caribbean, forming dense meadows in green turtle ( Chelonia mydas )—foraging ",{"id":301,"funder":7,"programme":8,"title":302,"piName":303,"institution":120,"country":12,"year":13,"amount":14,"abstract":304},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-863-12-013","A stress recovery signaling network for enhanced flooding tolerance in \u003Ci>Arabidopsis thaliana\u003C\u002Fi>","Elaine Yeung","Abiotic stresses in plants are often transient, and the recovery phase following stress removal is critical. Flooding, a major abiotic stress that negatively impacts plant biodiversity and agriculture, is a sequential stress where tolerance is strongly dependent on viability underwater and during the postflooding period. Here we show that in \u003Ci>Arabidopsis thaliana\u003C\u002Fi> accessions (Bay-0 and Lp2-6), different rates of submergence recovery correlate with submergence tolerance and fecundity. A geno",{"id":306,"funder":7,"programme":8,"title":307,"piName":308,"institution":204,"country":12,"year":13,"amount":14,"abstract":309},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-181-025","Functional significance of the optical properties of flowers for visual signalling","Casper J. van der Kooi","Here, we review current knowledge about different aspects of the floral visual signals, their anatomical and optical properties, and their functional significance in plant-pollinator visual signalling. We discuss common aspects, such as chromatic and achromatic contrast, hue, saturation and brightness, as well as less common types of visual signals, including gloss, fluorescence, polarization and iridescence in the context of salience of floral colour signals and their evolution, and highlight p",{"id":311,"funder":7,"programme":8,"title":312,"piName":313,"institution":120,"country":12,"year":13,"amount":14,"abstract":314},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-veni-863-13-020","Functional organization of postsynaptic glutamate receptors","Harold D. MacGillavry","Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the brain, responsible for mediating the vast majority of excitatory transmission in neuronal networks. The AMPA- and NMDA-type ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the fast synaptic responses, while metabotropic glutamate receptors (mGluRs) are coupled to downstream signaling cascades that act on much slower timescales. These functionally distinct receptor sub-types a",{"id":316,"funder":7,"programme":8,"title":317,"piName":318,"institution":319,"country":12,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-275-89-027","Recalibration of vocal affect by a dynamic face","Martijn Baart","Tilburg University","Perception of vocal affect is influenced by the concurrent sight of an emotional face. We demonstrate that the sight of an emotional face also can induce recalibration of vocal affect. Participants were exposed to videos of a 'happy' or 'fearful' face in combination with a slightly incongruous sentence with ambiguous prosody. After this exposure, ambiguous test sentences were rated as more 'happy' when the exposure phase contained 'happy' instead of 'fearful' faces. This auditory shift likely re",{"id":322,"funder":7,"programme":8,"title":323,"piName":324,"institution":187,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-101","Behaviour of subtidal sandbars in response to nourishments","Max Radermacher",{"id":326,"funder":7,"programme":8,"title":327,"piName":328,"institution":329,"country":12,"year":13,"amount":14,"abstract":330},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-090","Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action","Maikel Boot","Amsterdam UMC Location VUmc","Due to the rise of drug-resistant forms of tuberculosis, there is an urgent need for novel antibiotics to effectively combat these cases and shorten treatment regimens. Recently, drug screens using whole-cell analyses have been shown to be successful. However, current high-throughput screens focus mostly on \u003Ci>stricto sensu\u003C\u002Fi> life\u002Fdeath screening that give little qualitative information. In doing so, promising compound scaffolds or nonoptimized compounds that fail to reach inhibitory concentra",{"id":332,"funder":7,"programme":8,"title":333,"piName":334,"institution":335,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-veni-016156059","Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates","Raphaël Duivenvoorden","Amsterdam UMC Location University of Amsterdam",{"id":337,"funder":7,"programme":8,"title":338,"piName":339,"institution":91,"country":12,"year":13,"amount":14,"abstract":340},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-700-10-409","Customizing poly(lactic-co-glycolic acid) particles for biomedical applications","Mangala Srinivas","Nanoparticles are increasingly important in the field of biomedicine. Particles made of polymers are in the spotlight, due to their biodegradability, biocompatibility, versatility. In this review, we aim to discuss the range of formulation techniques, manipulations, and applications of poly(lactic-co-glycolic acid) (PLGA) particles, to enable a researcher to effectively select or design the optimal particles for their application. We describe the various techniques of PLGA particle synthesis and",{"id":342,"funder":7,"programme":8,"title":343,"piName":344,"institution":91,"country":12,"year":13,"amount":14,"abstract":345},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-016-176-024","Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement","Jakko van Ingen","Nontuberculous mycobacterial pulmonary diseases (NTM-PD) are increasingly recognised as opportunistic infections of humans. These chronic pulmonary infections have two main presentations. The first is a fibro-cavitary disease, that occurs in patients with pre-existing pulmonary diseases, such as chronic obstructive pulmonary disease, bronchiectasis, previous tuberculosis or other structural lung disease. The second presentation is a nodular-bronchiectatic disease of primarily the lingula and mid",{"id":347,"funder":7,"programme":8,"title":348,"piName":349,"institution":148,"country":12,"year":13,"amount":14,"abstract":350},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-451-15-33","Turkey’s governance of irregular migration at European Union borders: Emerging geographies of care and control","Beste İşleyen","Combining insights from critical studies on humanitarianism and scholarly work emphasising everyday practices, this study examines Turkish policing of human mobility at European Union borders in two border cities: Edirne and İzmir. Through a focus on the central understandings, justifications and operational responses by Turkish border officials, the article highlights the intertwinement of care and control as inherent to humanitarianism in the daily governance of mobile populations at Turkey’s ",{"id":352,"funder":7,"programme":8,"title":353,"piName":354,"institution":355,"country":356,"year":13,"amount":14,"abstract":357},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-125-040","Learning in network games","Jaromír Kovářík","Center for Economic Research and Graduate Education – Economics Institute","CZ","We report the findings of experiments designed to study how people learn in network games. Network games offer new opportunities to identify learning rules, since on networks (compared to, e.g., random matching) more rules differ in terms of their information requirements. Our experimental design enables us to observe both which actions participants choose and which information they consult before making their choices. We use these data to estimate learning types using finite mixture models. Mon",{"id":359,"funder":7,"programme":8,"title":360,"piName":361,"institution":97,"country":12,"year":13,"amount":14,"abstract":362},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-grant-916-16025","Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach","Tom van Meerten","Forty percent of patients with diffuse large B-cell lymphoma (DLBCL) show resistant disease to standard chemotherapy (CHOP) in combination with the anti-CD20 monoclonal antibody rituximab (R). Although many new anti-cancer drugs were developed in the last years, it is unclear which of these drugs can be safely combined to improve standard therapy without antagonizing anti-CD20 efficacy. In this study, we aimed to identify rituximab compatible drug-target combinations for DLBCL. For this, we coll",{"id":364,"funder":7,"programme":8,"title":365,"piName":366,"institution":335,"country":12,"year":13,"amount":14,"abstract":367},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-126-059","The measurement of cognitive reactivity to sad mood in patients remitted from major depressive disorder","Caroline Figueroa","We were not able to examine the effect of previous treatment, which could have affected results as psychological treatments probably have differential effects on CR. Examining un-medicated patients may have led to selection of a sample not completely representative for the general MDD population. We did not administer both parallel versions of the DAS (A\u002FB) before and after mood-induction. This might have provided better understanding of their differential sensitivity to change.",{"id":369,"funder":7,"programme":8,"title":370,"piName":371,"institution":372,"country":12,"year":13,"amount":14,"abstract":373},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-722-013-002","Coordination of 3‐Methylindole‐Based Tripodal Tetraphosphine Ligands to Iron(+II), Cobalt(+II), and Nickel(+II) and Investigations of their Subsequent Two‐Electron Reduction","Wojciech I. Dzik","Institute for Atomic and Molecular Physics","We report the coordination chemistry of indole based tripodal tetraphosphine ligands to iron(II), cobalt(II) and nickel(II). These complexes are formed by simple synthetic protocols and were characterized by a combination of spectroscopic techniques and single-crystal X-ray analysis. The molecular structures as determined by X-ray diffraction show that the geometry of the nickel and cobalt complexes are distorted trigonal bipyramidal. The monocationic iron(II) complexes also have distorted trigo",{"id":375,"funder":7,"programme":8,"title":376,"piName":377,"institution":378,"country":379,"year":13,"amount":14,"abstract":380},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-15924","Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles (AFFECT EV) in acute myocardial infarction","Aleksandra Gąsecka","Medical University of Warsaw","PL","Activated platelets contribute to thrombosis and inflammation by the release of extracellular vesicles (EVs) exposing P-selectin, phosphatidylserine (PS) and fibrinogen. P2Y12 receptor antagonists are routinely administered to inhibit platelet activation in patients after acute myocardial infarction (AMI), being a combined antithrombotic and anti-inflammatory therapy. The more potent P2Y12 antagonist ticagrelor improves cardiovascular outcome in patients after AMI compared to the less potent clo",{"id":382,"funder":7,"programme":8,"title":383,"piName":384,"institution":198,"country":12,"year":13,"amount":14,"abstract":385},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-188-040","Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects","Marjolein Bulk","We present a quantitative study of different molecular iron forms found in the temporal cortex of Alzheimer (AD) patients. Applying the methodology we developed in our previous work, we quantify the concentrations of non-heme Fe(III) by Electron Paramagnetic Resonance (EPR), magnetite\u002Fmaghemite and ferrihydrite by SQUID magnetometry, together with the MRI transverse relaxation rate [Formula: see text], to obtain a systematic view of molecular iron in the temporal cortex. Significantly higher val",{"id":387,"funder":7,"programme":8,"title":388,"piName":389,"institution":390,"country":12,"year":13,"amount":14,"abstract":391},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-026","The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation","Maksim V. Baranov","Radboud Institute for Molecular Life Sciences","Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo\u002Fphagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by small molecule inhibitors caused a delay in the conversion of phagosomes into lysosomes and in phagosomal acidification, whereas production of reactive oxygen species (ROS) increased. Elevated ROS resulted in reduced activ",{"id":393,"funder":7,"programme":8,"title":388,"piName":389,"institution":390,"country":12,"year":13,"amount":14,"abstract":391},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni",{"id":395,"funder":7,"programme":8,"title":396,"piName":397,"institution":398,"country":12,"year":13,"amount":14,"abstract":399},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-680-47-431","Colloid supported lipid bilayers for self-assembly","Daniela J. Kraft","Leiden University","The use of colloid supported lipid bilayers (CSLBs) has recently been extended to create colloidal joints, that enable the assembly of structures with internal degrees of flexibility, and to study lipid membranes on curved and closed geometries. These novel applications of CSLBs rely on previously unappreciated properties: the simultaneous fluidity of the bilayer, lateral mobility of inserted (linker) molecules and colloidal stability. Here we characterize every step in the manufacturing of CSLB",{"id":401,"funder":7,"programme":8,"title":402,"piName":403,"institution":44,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-14-035-","Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis","Amée F. Wolters",{"id":405,"funder":7,"programme":8,"title":406,"piName":407,"institution":91,"country":12,"year":13,"amount":14,"abstract":408},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-173-017","Key Prediction Security of Keyed Sponges","Bart Mennink","The keyed sponge is a well-accepted method for message authentication. It processes data at a certain rate by sequential evaluation of an underlying permutation. If the key size k is smaller than the rate, currently known bounds are tight, but if it exceeds the rate, state of the art only dictates security up to 2k\u002F2. We take closer inspection at the key prediction security of the sponge and close the remaining gap in the existing security analysis: we confirm key security up to close to 2k, reg",{"id":410,"funder":7,"programme":8,"title":411,"piName":412,"institution":413,"country":32,"year":13,"amount":14,"abstract":414},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-grant-016-veni-178-023","Predicted short and long-term impact of deworming and water, hygiene, and sanitation on transmission of soil-transmitted helminths","Luc E. Coffeng","Australian National University","The impact of WASH interventions on STH transmission highly depends on the worm species, WASH modality, and uptake and effectiveness of the intervention. Also, the impact of WASH is difficult to measure in the context of ongoing PCT programmes. Still, we show a clear added benefit of WASH to sustain the gains made by PCT in the long term, such that PCT may be scaled down or even stopped altogether. To safely stop or scale down PCT, policy for WASH and PCT should be integrated.",{"id":416,"funder":7,"programme":8,"title":411,"piName":412,"institution":413,"country":32,"year":13,"amount":14,"abstract":414},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-178-023",{"id":418,"funder":7,"programme":8,"title":411,"piName":412,"institution":413,"country":32,"year":13,"amount":14,"abstract":414},"openalex-nederlandse-organisatie-voor-wetenschapp-award-grant-016-veni-178-023",{"id":420,"funder":7,"programme":8,"title":71,"piName":72,"institution":73,"country":12,"year":13,"amount":14,"abstract":74},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-13681",80,{"programme":8,"total":423,"withPiName":423,"firstYear":424,"lastYear":425,"countryCount":426,"perYear":427,"topInstitutions":472,"topCountries":517},779,1999,2026,32,[428,430,433,436,439,442,445,448,449,452,455,458,461,464,467,470],{"year":424,"count":429},3,{"year":431,"count":432},2011,2,{"year":434,"count":435},2013,4,{"year":437,"count":438},2014,5,{"year":440,"count":441},2015,14,{"year":443,"count":444},2016,26,{"year":446,"count":447},2017,34,{"year":13,"count":421},{"year":450,"count":451},2019,27,{"year":453,"count":454},2020,42,{"year":456,"count":457},2021,51,{"year":459,"count":460},2022,56,{"year":462,"count":463},2023,103,{"year":465,"count":466},2024,110,{"year":468,"count":469},2025,139,{"year":425,"count":471},83,[473,475,477,478,480,481,482,484,486,489,490,492,494,496,497,498,500,502,504,507,509,511,513,514,516],{"name":120,"count":474},76,{"name":91,"count":476},58,{"name":204,"count":457},{"name":398,"count":479},40,{"name":148,"count":479},{"name":103,"count":451},{"name":20,"count":483},24,{"name":187,"count":485},23,{"name":487,"count":488},"Eindhoven University of Technology",17,{"name":73,"count":488},{"name":97,"count":491},15,{"name":154,"count":493},13,{"name":25,"count":495},10,{"name":198,"count":495},{"name":319,"count":495},{"name":109,"count":499},9,{"name":55,"count":501},8,{"name":38,"count":503},7,{"name":505,"count":506},"Centre National de la Recherche Scientifique",6,{"name":508,"count":506},"Royal Netherlands Institute for Sea Research",{"name":510,"count":506},"University of Copenhagen",{"name":512,"count":438},"Amsterdam University of Applied Sciences",{"name":372,"count":438},{"name":515,"count":438},"Maastricht University",{"name":44,"count":438},[518,520,521,523,526,529,531,533,534,536,537,539,541,543,545,546,547,549,550,552,554,556,559,561,563],{"name":12,"count":519},551,{"name":231,"count":444},{"name":181,"count":522},19,{"name":524,"count":525},"GB",18,{"name":527,"count":528},"FR",12,{"name":530,"count":499},"DK",{"name":532,"count":501},"IT",{"name":356,"count":503},{"name":535,"count":506},"AT",{"name":32,"count":506},{"name":538,"count":506},"BE",{"name":540,"count":506},"ES",{"name":542,"count":438},"CA",{"name":544,"count":438},"CN",{"name":379,"count":438},{"name":67,"count":438},{"name":548,"count":435},"NO",{"name":245,"count":429},{"name":551,"count":432},"CH",{"name":553,"count":432},"FI",{"name":555,"count":432},"IN",{"name":557,"count":558},"JP",1,{"name":560,"count":558},"KR",{"name":562,"count":558},"LK",{"name":564,"count":558},"MK"]