[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-veni-2021":3,"awarded-stats-nwo-veni":305},{"awarded":4,"total":304},[5,16,23,29,35,42,48,55,62,68,74,81,87,93,100,105,110,117,122,129,131,137,143,149,155,159,165,171,176,181,186,192,198,203,208,214,219,225,232,237,242,248,255,260,266,271,277,282,286,293,299],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-275-53-016","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Veni","The regional impact of an epidemic: socioeconomic and demographic data in Java, 1905-1924","Daniel Gallardo‐Albarrán","Wageningen University & Research","NL",2021,null,". The data concern trends in area of cultivated sugar, total and per-hectare sugar production, crude mortality rates and wages in the period ca. 1909-1924. In addition to this panel dataset, cross-sectional figures were collected about the amount of sawah land (1920), urbanization rates (1905), medical personnel (1919), native population (1905) and areas with communal property with rotating shares. These figures were gathered from primary documents published by the Dutch colonial government and ",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-237","Gysin sequences and SU(2)‐symmetries of C∗‐algebras","Jens Kaad","University of Southern Denmark","DK","Motivated by the study of symmetries of C*-algebras, as well as by multivariate operator theory, we introduce the notion of an SU(2)-equivariant subproduct system of Hilbert spaces. We analyse the resulting Toeplitz and Cuntz-Pimsner algebras and provide results about their topological invariants through Kasparov's bivariant K-theory. In particular, starting from an irreducible representation of SU(2), we show that the corresponding Toeplitz algebra is equivariantly KK-equivalent to the algebra ",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":12,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-192-198","Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice","Sarah Hescham","Maastricht University Medical Centre","Deep brain stimulation (DBS) has long been used to alleviate symptoms in patients suffering from psychiatric and neurological disorders through stereotactically implanted electrodes that deliver current to subcortical structures via wired pacemakers. The application of DBS to modulate neural circuits is, however, hampered by its mechanical invasiveness and the use of chronically implanted leads, which poses a risk for hardware failure, hemorrhage, and infection. Here, we demonstrate that a wirel",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-017","Verbal and General IQ Associate with Supragranular Layer Thickness and Cell Properties of the Left Temporal Cortex","Huibert D. Mansvelder","Amsterdam Neuroscience","The left temporal lobe is an integral part of the language system and its cortical structure and function associate with general intelligence. However, whether cortical laminar architecture and cellular properties of this brain area relate to verbal intelligence is unknown. Here, we addressed this using histological analysis and cellular recordings of neurosurgically resected temporal cortex in combination with presurgical IQ scores. We find that subjects with higher general and verbal IQ scores",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":40,"year":13,"amount":14,"abstract":41},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-veni-188-049","Learning to stand with unexpected sensorimotor delays","Jean‐Sébastien Blouin","Vancouver Coastal Health","CA","Human standing balance relies on self-motion estimates that are used by the nervous system to detect unexpected movements and enable corrective responses and adaptations in control. These estimates must accommodate for inherent delays in sensory and motor pathways. Here, we used a robotic system to simulate human standing about the ankles in the anteroposterior direction and impose sensorimotor delays into the control of balance. Imposed delays destabilized standing, but through training, partic",{"id":43,"funder":7,"programme":8,"title":44,"piName":45,"institution":46,"country":12,"year":13,"amount":14,"abstract":47},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-192-087","Multiscale Bayesian survival analysis","Stéphanie van der Pas","Amsterdam University Medical Centers","We consider Bayesian nonparametric inference in the right-censoring survival model, where modeling is made at the level of the hazard rate. We derive posterior limiting distributions for linear functionals of the hazard, and then for ‘many’ functionals simultaneously in appropriate multiscale spaces. As an application, we derive Bernstein–von Mises theorems for the cumulative hazard and survival functions, which lead to asymptotically efficient confidence bands for these quantities. Further, we ",{"id":49,"funder":7,"programme":8,"title":50,"piName":51,"institution":52,"country":53,"year":13,"amount":14,"abstract":54},"openalex-nederlandse-organisatie-voor-wetenschapp-award-ttw-016-veni-198-032","Linking cortical circuit models to human cognition with laminar fMRI","Jiajia Yang","Okayama University","JP","Laboratory animal research has provided significant knowledge into the function of cortical circuits at the laminar level, which has yet to be fully leveraged towards insights about human brain function on a similar spatiotemporal scale. The use of functional magnetic resonance imaging (fMRI) in conjunction with neural models provides new opportunities to gain important insights from current knowledge. During the last five years, human studies have demonstrated the value of high-resolution fMRI ",{"id":56,"funder":7,"programme":8,"title":57,"piName":58,"institution":59,"country":60,"year":13,"amount":14,"abstract":61},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-680-47-633-and-veni-grant-722-012-010","Structural Transformation of Surface‐Confined Porphyrin Networks by Addition of Co Atoms","V. Bulach","Centre National de la Recherche Scientifique","FR","The self-assembly of a nickel-porphyrin derivative (Ni-DPPyP) containing two pyridyl coordinating sites and two pentyl chains at trans meso positions was studied with scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED) on Au(111). Deposition of Ni-DPPyP onto Au(111) gave rise to a close-packed network for coverages smaller or equal to one monolayer as revealed by STM and LEED. The molecular arrangement of this two-dimensional net",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":66,"country":12,"year":13,"amount":14,"abstract":67},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-202-079","Microbial hitchhiking: how \u003Ci>Streptomyces\u003C\u002Fi> spores are transported by motile soil bacteria","Ariane Briegel","Leiden University","Streptomycetes are sessile bacteria that produce metabolites that impact the behavior of microbial communities. Emerging studies have demonstrated that Streptomyces spores are distributed through various mechanisms, but it remains unclear how spores are transported to their preferred microenvironments, such as plant roots. Here, we show that Streptomyces spores are capable of utilizing the motility machinery of other soil bacteria. Motility assays and microscopy studies reveal that Streptomyces ",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":12,"year":13,"amount":14,"abstract":73},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-jtww-no-016-156-019","Reflections on psychological resilience: a comparison of three conceptually different operationalizations in predicting mental health","Anna Kuranova","University Medical Center Groningen","Background: Psychological resilience refers to the ability to maintain mental health or recover quickly after stress. Despite the popularity of resilience research, there is no consensus understanding or operationalization of resilience. Objective: We plan to compare three indicators of resilience that each involve a different operationalization of the construct: a) General resilience or one's self-reported general ability to overcome adversities; b) Daily resilience as momentarily experienced a",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":79,"year":13,"amount":14,"abstract":80},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-195-261","Meta-analytic Gaussian Network Aggregation","Mike W.‐L. Cheung","National University of Singapore","SG","A growing number of publications focus on estimating Gaussian graphical models (GGM, networks of partial correlation coefficients). At the same time, generalizibility and replicability of these highly parameterized models are debated, and sample sizes typically found in datasets may not be sufficient for estimating the underlying network structure. In addition, while recent work emerged that aims to compare networks based on different samples, these studies do not take potential cross-study hete",{"id":82,"funder":7,"programme":8,"title":83,"piName":84,"institution":85,"country":12,"year":13,"amount":14,"abstract":86},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-202-035","Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in \u003Ci>Aedes aegypti\u003C\u002Fi> mosquitoes","Ronald P. van Rij","Radboud University Nijmegen","Abstract In the germline of animals, PIWI interacting (pi)RNAs protect the genome against the detrimental effects of transposon mobilization. In Drosophila, piRNA-mediated cleavage of transposon RNA triggers the production of responder piRNAs via ping-pong amplification. Responder piRNA 3′ end formation by the nuclease Zucchini is coupled to the production of downstream trailer piRNAs, expanding the repertoire of transposon piRNA sequences. In Aedes aegypti mosquitoes, piRNAs are generated from ",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":12,"year":13,"amount":14,"abstract":92},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-201g-045","Inclusion Bayes Factors for Mixed Hierarchical Diffusion Decision Models","Udo Boehm","University of Amsterdam","Cognitive models provide a substantively meaningful quantitative description of latent cognitive processes. The quantitative formulation of these models supports cumulative theory building and enables strong empirical tests. However, the non-linearity of these models and pervasive correlations among model parameters pose special challenges when applying cognitive models to data. Firstly, estimating cognitive models typically requires large hierarchical data sets that need to be accommodated by a",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":97,"country":98,"year":13,"amount":14,"abstract":99},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-201f-032","Revisiting Epistemic Logic with Names","Marta Bílková","Czech Academy of Sciences, Institute of Computer Science","CZ","This paper revisits the multi-agent epistemic logic presented in [10], where agents and sets of agents are replaced by abstract, intensional \"names\". We make three contributions. First, we study its model theory, providing adequate notions of bisimulation and frame morphisms, and use them to study the logic's expressive power and definability. Second, we show that the logic has a natural neighborhood semantics, which in turn allows to show that the axiomatization in [10] does not rely on possibl",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":91,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-195-159","Ticking all the boxes? A comparative study of social sorting and affective polarization","Eelco Harteveld","This study explores whether, in societies around the world, affective polarization – or animosity between citizens based on their political allegiance – is stronger if political divisions align with non-political ones. Such ‘social sorting’ has earlier been established to foster affective polarization in the United States. In this study, I argue that the underlying mechanism travels across the globe. I then present two complementary studies which confirm this hypothesis. First, I employ CSES dat",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":46,"country":12,"year":13,"amount":14,"abstract":109},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-198-017","Oncologists' Communication About Uncertain Information in Second Opinion Consultations: A Focused Qualitative Analysis","Marij A. Hillen","Introduction: Uncertainty is omnipresent in cancer care, including the ambiguity of diagnostic tests, efficacy and side effects of treatments, and\u002For patients' long-term prognosis. During second opinion consultations, uncertainty may be particularly tangible: doubts and uncertainty may drive patients to seek more information and request a second opinion, whereas the second opinion in turn may also affect patients' level of uncertainty. Providers are tasked to clearly discuss all of these uncerta",{"id":111,"funder":7,"programme":8,"title":112,"piName":113,"institution":114,"country":115,"year":13,"amount":14,"abstract":116},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-13-035-","Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum","Esther Hanssen","King's College London","GB","OBJECTIVE: Recent findings suggest that diminished processing of positive contextual information about others during interactions may contribute to social impairment in the schizophrenia spectrum. This could be due to general social context processing deficits or specific biases against positive information. We studied the impact of positive and negative social contextual information during social interactions using functional neuroimaging and probed whether these neural mechanisms were associat",{"id":118,"funder":7,"programme":8,"title":119,"piName":120,"institution":46,"country":12,"year":13,"amount":14,"abstract":121},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-186-046","Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients","Esther J. Nossent","Rationale: Systemic activation of procoagulant and inflammatory mechanisms has been implicated in the pathogenesis of COVID-19. Knowledge of activation of these host response pathways in the lung compartment of COVID-19 patients is limited. Objectives: To evaluate local and systemic activation of coagulation and interconnected inflammatory responses in critically ill COVID-19 patients with persistent acute respiratory distress syndrome. Methods: Paired bronchoalveolar lavage fluid and plasma sam",{"id":123,"funder":7,"programme":8,"title":124,"piName":125,"institution":126,"country":127,"year":13,"amount":14,"abstract":128},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-veni-173-076","Sustainable data analysis with Snakemake","Felix Mölder","University of Duisburg-Essen","DE","Data analysis often entails a multitude of heterogeneous steps, from the application of various command line tools to the usage of scripting languages like R or Python for the generation of plots and tables. It is widely recognized that data analyses should ideally be conducted in a reproducible way. Reproducibility enables technical validation and regeneration of results on the original or even new data. However, reproducibility alone is by no means sufficient to deliver an analysis that is of ",{"id":130,"funder":7,"programme":8,"title":124,"piName":125,"institution":126,"country":127,"year":13,"amount":14,"abstract":128},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-173-076",{"id":132,"funder":7,"programme":8,"title":133,"piName":134,"institution":135,"country":12,"year":13,"amount":14,"abstract":136},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-175-019","Get Real! Individuals Prefer More Sustainable Investments","Paul Smeets","Maastricht School of Management","Abstract The United Nations’ Sustainable Development Goals (SDGs) have created societal and political pressure for pension funds to address sustainable investing. We run two field surveys (n = 1,669, n = 3,186) with a pension fund that grants its members a real vote on its sustainable-investment policy. Two-thirds of participants are willing to expand the fund’s engagement with companies based on selected SDGs, even when they expect engagement to hurt financial performance. Support remains stron",{"id":138,"funder":7,"programme":8,"title":139,"piName":140,"institution":141,"country":12,"year":13,"amount":14,"abstract":142},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-262","CrossTalk: Speculative Data Leaks Across Cores Are Real","Hany Ragab","Vrije Universiteit Amsterdam","Recent transient execution attacks have demonstrated that attackers may leak sensitive information across security boundaries on a shared CPU core. Up until now, it seemed possible to prevent this by isolating potential victims and attackers on separate cores. In this paper, we show that the situation is more serious, as transient execution attacks can leak data across different cores on many modern Intel CPUs.We do so by investigating the behavior of x86 instructions, and in particular, we focu",{"id":144,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":115,"year":13,"amount":14,"abstract":148},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-project-no-16761","Selective dendritic localization of mRNA in Drosophila mushroom body output neurons","Scott Waddell","University of Oxford","Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments. Here, we used single-molecule fluorescence in situ hybridization to localize mRNAs at subcellular resolution in the adult Drosophila brain. mRNAs for subunits of nicotinic acetylcholine receptors and kinases could be detected within the dendrites of co-labeled mushroom body output ",{"id":150,"funder":7,"programme":8,"title":151,"piName":152,"institution":153,"country":12,"year":13,"amount":14,"abstract":154},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-722-017-003","Photo‐controlled alignment and helical organization in main‐chain liquid crystalline alternating polymers","Ghislaine Vantomme","Eindhoven University of Technology","Abstract Materials with highly ordered nanoscale structures can translate molecular processes to macroscopic function. Here we report on the photo‐controlled organization of achiral alternating copolymers composed of discrete length blocks showing well‐defined sub‐10 nm morphologies. These alternating copolymers consist of main‐chain azobenzene building blocks alternating with discrete o DMS blocks of various precise lengths. Remarkably, we demonstrate the imprinting of a stable helical molecula",{"id":156,"funder":7,"programme":8,"title":157,"piName":71,"institution":72,"country":12,"year":13,"amount":14,"abstract":158},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-016-156-019","Network dynamics of momentary affect states and future course of psychopathology in adolescents","BACKGROUND: Recent theories argue that an interplay between (i.e., network of) experiences, thoughts and affect in daily life may underlie the development of psychopathology. OBJECTIVE: To prospectively examine whether network dynamics of everyday affect states are associated with a future course of psychopathology in adolescents at an increased risk of mental disorders. METHODS: 159 adolescents from the East-Flanders Prospective Twin Study cohort participated in the study. At baseline, their mo",{"id":160,"funder":7,"programme":8,"title":161,"piName":162,"institution":163,"country":12,"year":13,"amount":14,"abstract":164},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-680-47-446","Magnetic Coupling in Colloidal Clusters for Hierarchical Self-Assembly","Laura Rossi","Delft University of Technology","Manipulating the way in which colloidal particles self-organize is a central challenge in the design of functional soft materials. Meeting this challenge requires the use of building blocks that interact with one another in a highly specific manner. Their fabrication, however, is limited by the complexity of the available synthesis procedures. Here, we demonstrate that, starting from experimentally available magnetic colloids, we can create a variety of complex building blocks suitable for hiera",{"id":166,"funder":7,"programme":8,"title":167,"piName":168,"institution":169,"country":12,"year":13,"amount":14,"abstract":170},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-195-257","Heeding supply chain disruption warnings: When and how do cross‐functional teams ensure firm robustness?","Thomas A. de Vries","University of Groningen","Abstract Firms can adopt several strategies to increase their robustness to potential supply chain (SC) disruptions. One promising strategy is the use of a cross‐functional team with representatives from functional departments. Such a team may facilitate sharing relevant information, enabling the firm to respond effectively to SC disruption warnings. However, despite their potential, cross‐functional teams also differ in their ability to respond to SC disruption warnings and to ensure firm robus",{"id":172,"funder":7,"programme":8,"title":173,"piName":174,"institution":175,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-14-003","Predicting data quality of proxy reports in egocentric network studies","Tobias Stark","Utrecht University",{"id":177,"funder":7,"programme":8,"title":178,"piName":179,"institution":169,"country":12,"year":13,"amount":14,"abstract":180},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-175-078","Pupil Size Reflects Exploration and Exploitation in Visual Search (and It’s Like Object-Based Attention)","Sebastiaan Mathôt","Abstract The adaptive gain theory (AGT) posits that activity in the locus coeruleus (LC) is linked to two behavioral modes: exploitation, characterized by focused attention on a single task; and exploration, characterized by a lack of focused attention and frequent switching between tasks. Furthermore, pupil size correlates with LC activity, such that large pupils indicate increased LC firing, and by extension also exploration behavior. Most evidence for this correlation in humans comes from com",{"id":182,"funder":7,"programme":8,"title":183,"piName":184,"institution":46,"country":12,"year":13,"amount":14,"abstract":185},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-zonmw-veni-016-146-086-and-nwo-enw-vidi-198-015","Non-invasively measured brain activity and radiological progression in diffuse glioma","Linda Douw","Abstract Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoencephalography (MEG) was recorded in 45 diffuse glioma patients. Brain activity was estimated using three measures (absolute broadband power, offs",{"id":187,"funder":7,"programme":8,"title":188,"piName":189,"institution":190,"country":12,"year":13,"amount":14,"abstract":191},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-016-veni-171-090-","Heterologous Expression of \u003Ci>ethA\u003C\u002Fi> and \u003Ci>katG\u003C\u002Fi> in Mycobacterium marinum Enables the Rapid Identification of New Prodrugs Active against Mycobacterium tuberculosis","Alexander Speer","Amsterdam UMC Location Vrije Universiteit Amsterdam","Screening strategies for antituberculosis compounds using Mycobacterium tuberculosis are time consuming and require biosafety level 3 (BSL3) facilities, which makes the development of high-throughput assays difficult and expensive. Mycobacterium marinum , a close genetic relative of M. tuberculosis , possesses several advantages as a suitable model for tuberculosis drug screening. However, despite the high genetic similarity, there are some obvious differences in susceptibility to some tuberculo",{"id":193,"funder":7,"programme":8,"title":194,"piName":195,"institution":196,"country":12,"year":13,"amount":14,"abstract":197},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-639-041-750","Strong reduction of quasiparticle fluctuations in a superconductor due to decoupling of the quasiparticle number and lifetime","Steven A. H. de Rooij","Space Research Organisation Netherlands","We measure temperature-dependent quasiparticle fluctuations in a small Al volume, embedded in a NbTiN superconducting microwave resonator. The resonator design allows for readout close to equilibrium. By placing the Al film on a membrane, we enhance the fluctuation level and separate quasiparticle effects from phonon effects. When lowering the temperature, the recombination time saturates and the fluctuation level reduces by a factor $\\ensuremath{\\sim}100$. From this we deduce that the number of",{"id":199,"funder":7,"programme":8,"title":200,"piName":201,"institution":14,"country":14,"year":13,"amount":14,"abstract":202},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-15872-","Comparison of round- and square-core fibers for sensing, imaging and spectroscopy","Amitonova, Lyubov V.","Multimode fibers (MMFs) show great promise as miniature probes for sensing,\u003Cbr\u002F>imaging and spectroscopy applications. Different parameters of the fibers, such as numerical aperture, refractive index profile and length, have been already optimized for better performance. Here we investigate the role of the core shape, in particular for wavefront shaping applications where a focus is formed at the output of the MMF. We demonstrate that in contrast to a conventional round-core MMF, a square-core d",{"id":204,"funder":7,"programme":8,"title":205,"piName":206,"institution":163,"country":12,"year":13,"amount":14,"abstract":207},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-722-015-011","Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade","Caroline E. Paul","enzymatic asymmetric epoxidation, followed by regioselective azidolysis, affording the azido alcohols with up to two contiguous stereogenic centers. A newly isolated two-component flavoprotein styrene monooxygenase StyA proved to be highly selective for epoxidation with a nicotinamide coenzyme biomimetic as a practical reductant. Coupled with azide as a nucleophile for regioselective ring opening, this chemo-enzymatic cascade produced highly enantioenriched aromatic α-azido alcohols with up to >",{"id":209,"funder":7,"programme":8,"title":210,"piName":211,"institution":212,"country":12,"year":13,"amount":14,"abstract":213},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-185-260","New Interview Method for Sketching the Dynamic Relational and Sexual History of Young Adults","Daphne van de Bongardt","Erasmus University Rotterdam","Abstract Introduction Scientific literature and clinical practice still pay insufficient attention to the interconnectedness between love and sex. Especially youth would benefit in their sexual development from more attention (e.g., in parenting, education, sexual health services) for the complex relational context of sexual decisions and interactions. Methods To gain more insight into young people’s dynamically intertwined early experiences with romantic relationships and sexuality, a new semi-",{"id":215,"funder":7,"programme":8,"title":216,"piName":217,"institution":169,"country":12,"year":13,"amount":14,"abstract":218},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-191f-001","Divine Logos and Translation among Iberian Muslims: From Ibn Ḥazm (d. 456H\u002F1064CE) to Aḥmad al-Ḥanafī (d. 1049H\u002F1650CE)","Mònica Colominas Aparicio","Like other religious traditions, Islam has accommodated notions of the divine logos. The actual elaboration of these notions has been heavily dependent on how the translation of God’s word and commandments to humans were understood as an object of intra-community debate, as well as in polemics with non-Muslims (inter-community debate). These two debates converged in the Muslim critique of the translation, transmission, and interpretation of the divine logos by Jews and Christians in their script",{"id":220,"funder":7,"programme":8,"title":221,"piName":222,"institution":223,"country":12,"year":13,"amount":14,"abstract":224},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-191r-040","Asylum in the EU: One of the Many Faces of Rule of Law Backsliding?","Evangelia Tsourdi","Dutch Research Council","EU values – Rule of law backsliding – Rule of law and fundamental rights interrelation – Refugee protection – Common European Asylum System – Implementation gap in asylum – Lack of fair responsibility sharing in asylum – Structural deficiencies in national asylum systems – Defiance of asylum obligations and the duty of sincere cooperation – Systemic fundamental rights violations – Upholding the rule of law – European Asylum System redesign – Systemic infringement actions – Rule of law monitoring",{"id":226,"funder":7,"programme":8,"title":227,"piName":228,"institution":229,"country":230,"year":13,"amount":14,"abstract":231},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-195-412","International connectivity and the location of multinational enterprises' \u003Cscp>knowledge‐intensive\u003C\u002Fscp> activities: Evidence from \u003Cscp>US\u003C\u002Fscp> metropolitan areas","Davide Castellani","University of Perugia","IT","Abstract Research summary International connectivity is a multidimensional construct that plays a pivotal role in attracting the activities of multinational enterprises (MNEs) by facilitating intra‐firm coordination and access to external resources. We conceptualize how the different dimensions of international connectivity determine the location of MNEs' knowledge‐intensive activities, with a focus on Research and Development (R&D) laboratories and Headquarter units (HQ). By analyzing 3,101",{"id":233,"funder":7,"programme":8,"title":234,"piName":235,"institution":175,"country":12,"year":13,"amount":14,"abstract":236},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-047","Arithmetic of higher-dimensional orbifolds and a mixed Waring problem","Shuntaro Yamagishi","Abstract We study the density of rational points on a higher-dimensional orbifold $$(\\mathbb {P}^{n-1},\\Delta )$$ \u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\">\u003Cmml:mrow>\u003Cmml:mo>(\u003C\u002Fmml:mo>\u003Cmml:msup>\u003Cmml:mrow>\u003Cmml:mi>P\u003C\u002Fmml:mi>\u003C\u002Fmml:mrow>\u003Cmml:mrow>\u003Cmml:mi>n\u003C\u002Fmml:mi>\u003Cmml:mo>-\u003C\u002Fmml:mo>\u003Cmml:mn>1\u003C\u002Fmml:mn>\u003C\u002Fmml:mrow>\u003C\u002Fmml:msup>\u003Cmml:mo>,\u003C\u002Fmml:mo>\u003Cmml:mi>Δ\u003C\u002Fmml:mi>\u003Cmml:mo>)\u003C\u002Fmml:mo>\u003C\u002Fmml:mrow>\u003C\u002Fmml:math> when $$\\Delta $$ \u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\">\u003Cmml:mi>Δ\u003C\u002Fmml:",{"id":238,"funder":7,"programme":8,"title":239,"piName":240,"institution":241,"country":21,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-186","A Whitehead theorem for periodic homotopy groups","Tobias Barthel","University of Copenhagen",{"id":243,"funder":7,"programme":8,"title":244,"piName":245,"institution":246,"country":12,"year":13,"amount":14,"abstract":247},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-451-17-008","Using machine learning to predict the likelihood of future risk taking","T.S. Todor","Netherlands Institute for Neuroscience","Adolescents show more risk taking behavior than children and adults. Most adolescents do not experience adverse consequences of this increased risk taking behavior. However, excessive risk taking can result in long term adverse consequences. To better target prevention efforts at those adolescents who are at risk for excessive risk taking, these adolescents should be identified early. Here we first test which statistical approach is best suited to predict the likelihood of risk taking behavior. ",{"id":249,"funder":7,"programme":8,"title":250,"piName":251,"institution":252,"country":253,"year":13,"amount":14,"abstract":254},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-192-062","Universal activity-based labeling method for ammonia- and alkane-oxidizing bacteria","Dimitra Sakoula","University of Vienna","AT","The advance of metagenomics in combination with intricate cultivation approaches has facilitated the discovery of novel ammonia-, methane-, and other short-chain alkane-oxidizing microorganisms, indicating that our understanding of the microbial biodiversity within the biogeochemical nitrogen and carbon cycles still is incomplete. The in situ detection and phylogenetic identification of novel ammonia- and alkane-oxidizing bacteria remain challenging due to their naturally low abundances and diff",{"id":256,"funder":7,"programme":8,"title":257,"piName":258,"institution":141,"country":12,"year":13,"amount":14,"abstract":259},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-15-005","Protecting working welfare recipients through human rights experimentalism","Anja Eleveld","Abstract In this paper, we adopt an experimentalist approach to determining the content of international human rights for assessing national mandatory work programmes for recipients of social assistance (MWPs). This approach implies going back and forth between law and experience in order to determine the better way to secure human rights in an ever-changing environment. After having identified six criteria for evaluating MWPs in the soft case-law of international bodies, we confront this emergi",{"id":261,"funder":7,"programme":8,"title":262,"piName":263,"institution":264,"country":127,"year":13,"amount":14,"abstract":265},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-016-186-012","mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy","Karl P. Schlingmann","University Hospital Münster","Significance Statement Although advances in genetic techniques have resulted in the identification of rare hereditary disorders of renal magnesium and salt handling, some patients with tubulopathy lack a genetic diagnosis. In a cohort of patients with profound hypomagnesemia, renal salt wasting, nephrocalcinosis, and dilated cardiomyopathy, the authors performed whole-exome and -genome sequencing and identified heterozygous variants in RRAGD, which encodes a small Rag guanosine triphosphatase (G",{"id":267,"funder":7,"programme":8,"title":268,"piName":269,"institution":169,"country":12,"year":13,"amount":14,"abstract":270},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-722-017-001","Rational design of ASCT2 inhibitors using an integrated experimental-computational approach","Cristina Paulino","ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient deprivation via ASCT2 inhibition provides a potential strategy for cancer therapy. Here, we rationally designed stereospecific inhibitors exploiting specific subpockets in the substrate binding site using computational modeling and cryo-electron micro",{"id":272,"funder":7,"programme":8,"title":273,"piName":274,"institution":275,"country":12,"year":13,"amount":14,"abstract":276},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-195-502","X-ray computed tomography for non-invasive dendrochronology reveals a concealed double panelling on a painting from Rubens’ studio","Marta Domínguez‐Delmás","Rijksmuseum","Dating the wood from historical art objects is a crucial step to ascertain their production time, and support or refute attribution to an artist or a workshop. Dendrochronology is commonly used for this purpose but requires access to the tree-ring pattern in the wood, which can be hindered by preparatory layers, polychromy, wax, or integrated frames. Here we implemented non-invasive dendrochronology based on X-ray computed tomography (CT) to examine a painting on panel attributed to Rubens' stud",{"id":278,"funder":7,"programme":8,"title":279,"piName":280,"institution":11,"country":12,"year":13,"amount":14,"abstract":281},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-veni-171-047","SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation","Jurre A. Steens","Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of the target RNA and production of cyclic oligoadenylate (cOA) molecules. Here we report that an exposed seed region at the 3' end of the crRNA is essential for target RNA binding and cleavage, whereas cOA production requires base pairing at the 5' end of the crRNA. Moreover, we uncover that the variat",{"id":283,"funder":7,"programme":8,"title":284,"piName":285,"institution":241,"country":21,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-451-13-017-veni-2014-","An axiomatic re-characterization of the Kemeny rule","Mohsen Pourpouneh",{"id":287,"funder":7,"programme":8,"title":288,"piName":289,"institution":290,"country":291,"year":13,"amount":14,"abstract":292},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-194-033","Comment on nhess-2021-188 with annotated pdf (supplement)","Zhu, Weihua","Beijing Normal University","CN","\u003Cstrong class=\"journal-contentHeaderColor\">Abstract.\u003C\u002Fstrong> Floods have negative effects on the reliable operation of transportation systems. In China alone, floods cause an average of \u003Cspan class=\"inline-formula\">∼1125\u003C\u002Fspan> h of railway service disruptions per year. In this study, we present a simulation framework to analyse the system vulnerability and risk of the railway system to floods. First, we developed a novel methodology for generating flood events at both the national and rive",{"id":294,"funder":7,"programme":8,"title":295,"piName":296,"institution":297,"country":127,"year":13,"amount":14,"abstract":298},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-10019853","The VC Dimension of Metric Balls under Fréchet and Hausdorff Distances","Anne Driemel","University of Bonn","Abstract The Vapnik–Chervonenkis dimension provides a notion of complexity for systems of sets. If the VC dimension is small, then knowing this can drastically simplify fundamental computational tasks such as classification, range counting, and density estimation through the use of sampling bounds. We analyze set systems where the ground set X is a set of polygonal curves in $$\\mathbb {R}^d$$ \u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\"> \u003Cmml:msup> \u003Cmml:mrow> \u003Cmml:mi>R\u003C\u002Fmml:mi> \u003C\u002Fmml",{"id":300,"funder":7,"programme":8,"title":301,"piName":302,"institution":175,"country":12,"year":13,"amount":14,"abstract":303},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-veni-202-113","ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability","Nazmiye Özkan","Neuronal function relies on careful coordination of organelle organization and transport. Kinesin-1 mediates transport of the endoplasmic reticulum (ER) and lysosomes into the axon and it is increasingly recognized that contacts between the ER and lysosomes influence organelle organization. However, it is unclear how organelle organization, inter-organelle communication and transport are linked and how this contributes to local organelle availability in neurons. Here, we show that somatic ER tub",51,{"programme":8,"total":306,"withPiName":306,"firstYear":307,"lastYear":308,"countryCount":309,"perYear":310,"topInstitutions":355,"topCountries":403},779,1999,2026,32,[311,313,316,319,322,325,328,331,334,337,340,341,344,347,350,353],{"year":307,"count":312},3,{"year":314,"count":315},2011,2,{"year":317,"count":318},2013,4,{"year":320,"count":321},2014,5,{"year":323,"count":324},2015,14,{"year":326,"count":327},2016,26,{"year":329,"count":330},2017,34,{"year":332,"count":333},2018,80,{"year":335,"count":336},2019,27,{"year":338,"count":339},2020,42,{"year":13,"count":304},{"year":342,"count":343},2022,56,{"year":345,"count":346},2023,103,{"year":348,"count":349},2024,110,{"year":351,"count":352},2025,139,{"year":308,"count":354},83,[356,358,360,361,363,364,365,367,369,371,373,375,378,380,382,384,386,388,391,393,395,396,398,400,402],{"name":175,"count":357},76,{"name":85,"count":359},58,{"name":169,"count":304},{"name":66,"count":362},40,{"name":91,"count":362},{"name":11,"count":336},{"name":141,"count":366},24,{"name":163,"count":368},23,{"name":153,"count":370},17,{"name":372,"count":370},"University of Twente",{"name":72,"count":374},15,{"name":376,"count":377},"Erasmus MC",13,{"name":46,"count":379},10,{"name":381,"count":379},"Leiden University Medical Center",{"name":383,"count":379},"Tilburg University",{"name":212,"count":385},9,{"name":33,"count":387},8,{"name":389,"count":390},"University Medical Center Utrecht",7,{"name":59,"count":392},6,{"name":394,"count":392},"Royal Netherlands Institute for Sea Research",{"name":241,"count":392},{"name":397,"count":321},"Amsterdam University of Applied Sciences",{"name":399,"count":321},"Institute for Atomic and Molecular Physics",{"name":401,"count":321},"Maastricht University",{"name":27,"count":321},[404,406,408,410,412,414,415,416,417,418,420,422,424,425,426,428,430,432,434,436,438,440,442,444,446],{"name":12,"count":405},551,{"name":407,"count":327},"US",{"name":127,"count":409},19,{"name":115,"count":411},18,{"name":60,"count":413},12,{"name":21,"count":385},{"name":230,"count":387},{"name":98,"count":390},{"name":253,"count":392},{"name":419,"count":392},"AU",{"name":421,"count":392},"BE",{"name":423,"count":392},"ES",{"name":40,"count":321},{"name":291,"count":321},{"name":427,"count":321},"PL",{"name":429,"count":321},"ZA",{"name":431,"count":318},"NO",{"name":433,"count":312},"SE",{"name":435,"count":315},"CH",{"name":437,"count":315},"FI",{"name":439,"count":315},"IN",{"name":53,"count":441},1,{"name":443,"count":441},"KR",{"name":445,"count":441},"LK",{"name":447,"count":441},"MK"]