[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2013":3,"awarded-stats-nwo-vici":30},{"awarded":4,"total":29},[5,16,23],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-130-664","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B\u002FARL-13 to an Inv-like Ciliary Membrane Subdomain","Oliver E. Blacque","University College Dublin","IE",2013,null,"Cilia are microtubule-based cell appendages, serving motility, chemo-\u002Fmechano-\u002Fphoto- sensation, and developmental signaling functions. Cilia are comprised of distinct structural and functional subregions including the basal body, transition zone (TZ) and inversin (Inv) compartments, and defects in this organelle are associated with an expanding spectrum of inherited disorders including Bardet-Biedl syndrome (BBS), Meckel-Gruber Syndrome (MKS), Joubert Syndrome (JS) and Nephronophthisis (NPHP). ",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vici-918-86-616","Increased Risk of Sudden Cardiac Arrest in Obstructive Pulmonary Disease: A Case-Control Study","Miriam J. Warnier","Utrecht University","NL","BACKGROUND: We aimed to determine whether (1) patients with obstructive pulmonary disease (OPD) have an increased risk of sudden cardiac arrest (SCA) due to ventricular tachycardia or fibrillation (VT\u002FVF), and (2) the SCA risk is mediated by cardiovascular risk-profile and\u002For respiratory drug use. METHODS: A community-based case-control study was performed, with 1310 cases of SCA of the ARREST study and 5793 age, sex and SCA-date matched non-SCA controls from the PHARMO database. Only incident S",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":21,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-700-56-441","Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation","Roland Kanaar","Erasmus MC","Caffeine is a widely used inhibitor of the protein kinases that play a central role in the DNA damage response. We used chemical inhibitors and genetically deficient mouse embryonic stem cell lines to study the role of DNA damage response in stable integration of the transfected DNA and found that caffeine rapidly, efficiently and reversibly inhibited homologous integration of the transfected DNA as measured by several homologous recombination-mediated gene-targeting assays. 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