[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2018":3,"awarded-stats-nwo-vici":334},{"awarded":4,"total":333},[5,16,22,27,33,39,45,51,57,63,69,71,77,82,87,94,99,101,107,112,116,118,123,128,134,139,144,150,156,161,166,168,172,174,179,181,187,193,200,206,211,217,222,227,232,237,242,246,250,255,260,265,270,276,278,284,290,297,303,308,311,316,321,323,328],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-918-10-628","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Stimulated Raman scattering microscopy with long wavelengths for improved imaging depth","Freek Ariese","Vrije Universiteit Amsterdam","NL",2018,null,"Abstract Stimulated Raman scattering (SRS) imaging is a fast, label‐free, and sensitive technique to map the distribution of a vibrational species in a microscopy setting. It has great potential for applications in many fields, such as lipid imaging in biomedicine. However, depth penetration of the light into the sample is an issue with any light‐based technique, especially with multiphoton techniques such as SRS. Using longer wavelengths allows deeper penetration into densely scattering materia",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-639-033-413","Robust heavy-traffic approximations for service systems facing overdispersed demand","Britt W. J. Mathijsen","Eindhoven University of Technology","Arrival processes to service systems often display fluctuations that are larger than anticipated under the Poisson assumption, a phenomenon that is referred to as overdispersion . Motivated by this, we analyze a class of discrete-time stochastic models for which we derive heavy-traffic approximations that are scalable in the system size. Subsequently, we show how this leads to novel capacity sizing rules that acknowledge the presence of overdispersion. This, in turn, leads to robust approximatio",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":20,"country":12,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-150-366","Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks","Maarten Merkx","Protease signaling and scaffold-induced control of protein-protein interactions represent two important mechanisms for intracellular signaling. Here we report a generic and modular approach to control the activity of scaffolding proteins by protease activity, creating versatile molecular platforms to construct synthetic signaling networks. Using 14-3-3 proteins as a structurally well-characterized and important class of scaffold proteins, three different architectures were explored to achieve op",{"id":28,"funder":7,"programme":8,"title":29,"piName":30,"institution":31,"country":12,"year":13,"amount":14,"abstract":32},"openalex-nederlandse-organisatie-voor-wetenschapp-award-grants-016-vici-170-165","Protein interactome mapping in Caenorhabditis elegans","Mike Boxem","Utrecht University","The systematic identification of all protein–protein interactions that take place in an organism (the ‘interactome’) is an important goal in modern biology. The nematode Caenorhabditis elegans was one of the first multicellular models for which a proteome-wide interactome mapping project was initiated. Most Caenorhabditis elegans interactome mapping efforts have utilized the yeast two-hybrid system, yielding an extensive binary interactome, while recent developments in mass spectrometry-based ap",{"id":34,"funder":7,"programme":8,"title":35,"piName":36,"institution":37,"country":12,"year":13,"amount":14,"abstract":38},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-639-043-512-","The dependence of intrinsic alignment of galaxies on wavelength using KiDS and GAMA","Arun Kannawadi","Leiden University","The outer regions of galaxies are more susceptible to the tidal interactions that lead to intrinsic alignments of galaxies. The resulting alignment signal may therefore depend on the passband if the colours of galaxies vary spatially. To quantify this, we measured the shapes of galaxies with spectroscopic redshifts from the GAMA survey using deep gri imaging data from the KiloDegree Survey. The performance of the moment-based shape measurement algorithm DEIMOS was assessed using dedicated image ",{"id":40,"funder":7,"programme":8,"title":41,"piName":42,"institution":43,"country":12,"year":13,"amount":14,"abstract":44},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-45312015","Decision-Making Deficits in ADHD Are Not Related to Risk Seeking But to Suboptimal Decision-Making: Meta-Analytical and Novel Experimental Evidence","Tycho J. Dekkers","De Bascule","Objective: ADHD is related to decision-making deficits in real-life (e.g., substance abuse) and on experimental tasks (increased preference for risky options). In most tasks, risk and expected value are confounded (risky options have lowest expected value), making it impossible to disentangle risky from suboptimal (i.e., not choosing highest expected value) decision-making. We differentiated between risky and suboptimal decision-making in ADHD in two studies. Method and Results: First, on a mult",{"id":46,"funder":7,"programme":8,"title":47,"piName":48,"institution":49,"country":12,"year":13,"amount":14,"abstract":50},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-14-016","Defending one's friends, not one's enemies: A social network analysis of children's defending, friendship, and dislike relationships using XPNet","Beau Oldenburg","University of Groningen","Previous studies investigating to what extent students in elementary schools defend their victimized classmates typically treated defending as an individual characteristic. Defending should, however, be seen as a directed dyadic relationship between a victim and a defender, who are embedded multiple positive and negative relationships with each other and their classmates. Accordingly, in the present study defending was investigated using social network analysis. More specifically, it was investi",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":55,"country":12,"year":13,"amount":14,"abstract":56},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-083","The Support Interval","Eric‐Jan Wagenmakers","University of Amsterdam","A frequentist confidence interval can be constructed by inverting a hypothesis test, such that the interval contains only parameter values that would not have been rejected by the test. We show how a similar definition can be employed to construct a Bayesian support interval. Consistent with Carnap’s theory of corroboration, the support interval contains only parameter values that receive at least some minimum amount of support from the data. The support interval is not subject to Lindley’s para",{"id":58,"funder":7,"programme":8,"title":59,"piName":60,"institution":61,"country":12,"year":13,"amount":14,"abstract":62},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-865-12-004","Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy","Geert J.P.L. Kops","Oncode Institute","Summary The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by monitoring kinetochore-microtubule interactions. SAC proteins are shed from kinetochores once stable attachments are achieved. Human kinetochores consist of hundreds of SAC protein recruitment modules and bind up to 20 microtubules, raising the question how the SAC responds to intermediate attachment states. We show that the ‘RZZS-MAD1\u002F2’ module of the SAC is removed from kinetochores at low microtubule occupa",{"id":64,"funder":7,"programme":8,"title":65,"piName":66,"institution":67,"country":12,"year":13,"amount":14,"abstract":68},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-453-14-005","Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders","Lisa Hinz","Amsterdam Neuroscience","Generation of proper controls is crucial in induced pluripotent stem cell (iPSC) studies. X-chromosomal disorders offer the potential to develop isogenic controls due to random X-chromosomal inactivation (XCI). However, the generation of such lines is currently hampered by skewed X-inactivation in fibroblast lines and X-chromosomal reactivation (XCR) after reprogramming. Here we describe a method to generate a pure iPSC population with respect to the specific inactivated X-chromosome (Xi). We us",{"id":70,"funder":7,"programme":8,"title":65,"piName":66,"institution":67,"country":12,"year":13,"amount":14,"abstract":68},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-14-005",{"id":72,"funder":7,"programme":8,"title":73,"piName":74,"institution":75,"country":12,"year":13,"amount":14,"abstract":76},"openalex-nederlandse-organisatie-voor-wetenschapp-award-017-vici-106-370","The Longitudinal Relation between Observed Maternal Parenting in the Preschool Period and the Occurrence of Child ADHD Symptoms in Middle Childhood","Rianne Kok","Erasmus University Rotterdam","In this longitudinal population-based cohort (N = 547) we examined the relation between maternal discipline and sensitivity in the preschool period and the occurrence of attention-deficit hyperactivity disorder (ADHD) symptoms in middle childhood, taking into account pre-existing child attention and executive function (EF) problems, and oppositional defiant disorder (ODD) symptom comorbidity. Maternal parenting was observed during a 'do not touch task' (positive and negative discipline) and a te",{"id":78,"funder":7,"programme":8,"title":79,"piName":80,"institution":67,"country":12,"year":13,"amount":14,"abstract":81},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-91818602","Cardiac Disorders and Pathophysiology of Sarcomeric Proteins","Jolanda van der Velden","The sarcomeric proteins represent the structural building blocks of heart muscle, which are essential for contraction and relaxation. During recent years, it has become evident that posttranslational modifications of sarcomeric proteins, in particular phosphorylation, tune cardiac pump function at rest and during exercise. This delicate, orchestrated interaction is also influenced by mutations, predominantly in sarcomeric proteins, which cause hypertrophic or dilated cardiomyopathy. In this revi",{"id":83,"funder":7,"programme":8,"title":84,"piName":85,"institution":31,"country":12,"year":13,"amount":14,"abstract":86},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-130-662","A systematic review on the quantitative relationship between structural and functional network connectivity strength in mammalian brains","Milou Straathof","The mammalian brain is composed of densely connected and interacting regions, which form structural and functional networks. An improved understanding of the structure-function relation is crucial to understand the structural underpinnings of brain function and brain plasticity after injury. It is currently unclear how functional connectivity strength relates to structural connectivity strength. We obtained an overview of recent papers that report on correspondences between quantitative function",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":92,"year":13,"amount":14,"abstract":93},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-918-11-626","Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo","Sabil Huda","Northwestern University","US","Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long \"flig",{"id":95,"funder":7,"programme":8,"title":96,"piName":97,"institution":31,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-016-vici-170-072","Mineral formation induced by cable bacteria performing long-distance electron transport in marine sediments","Nicole M. J. Geerlings","Abstract. Cable bacteria are multicellular, filamentous microorganisms that are capable of transporting electrons over centimeter-scale distances. Although recently discovered, these bacteria appear to be widely present in the seafloor, and when active, they exert a strong imprint on the local geochemistry. In particular, their electrogenic metabolism induces unusually strong pH excursions in aquatic sediments, which induces considerable mineral dissolution, and subsequent mineral re-precipitati",{"id":100,"funder":7,"programme":8,"title":96,"piName":97,"institution":31,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-072",{"id":102,"funder":7,"programme":8,"title":103,"piName":104,"institution":105,"country":92,"year":13,"amount":14,"abstract":106},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-453-08-01","Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects","Scott Mackey","Media Working Group","The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.",{"id":108,"funder":7,"programme":8,"title":109,"piName":110,"institution":31,"country":12,"year":13,"amount":14,"abstract":111},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-140-316-13710","Growing Forced Bars Determine Nonideal Estuary Planform","Jasper R. F. W. Leuven","The planform of estuaries is often described with an ideal shape, which exponentially converges in landward direction. We show how growing topographically forced nonmigratory (i.e., anchored) bars determine the large‐scale estuary planform, which explains the deviations observed in the planform of natural estuaries filled with bars compared to the ideal planform. Experiments were conducted in a 20‐m long, 3‐m‐wide tilting flume, the Metronome. From a narrow, converging channel a self‐formed estu",{"id":113,"funder":7,"programme":8,"title":114,"piName":115,"institution":37,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-453-14-001","The development of self-views across adolescence: Investigating self-descriptions with and without social comparison using a novel experimental paradigm","L.P.E. van der Aar",{"id":117,"funder":7,"programme":8,"title":114,"piName":115,"institution":37,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-14-001",{"id":119,"funder":7,"programme":8,"title":120,"piName":121,"institution":11,"country":12,"year":13,"amount":14,"abstract":122},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-865-14-005","\u003Ci>In vivo\u003C\u002Fi> characterisation of fluorescent proteins in budding yeast","Dennis Botman","Abstract Fluorescent proteins (FPs) are widely used in many organisms, but are commonly characterised in vitro. However, the in vitro properties may poorly reflect in vivo performance. Therefore, we characterised 27 FPs in vivo using Saccharomyces cerevisiae as model organism. We linked the FPs via a T2A peptide to a control FP, producing equimolar expression of the 2 FPs from 1 plasmid. Using this strategy, we characterised the FPs for brightness, photostability, photochromicity and pH-sensitiv",{"id":124,"funder":7,"programme":8,"title":125,"piName":126,"institution":31,"country":12,"year":13,"amount":14,"abstract":127},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vici-865-10-010","Local microtubule organization promotes cargo transport in \u003Ci>C. elegans\u003C\u002Fi> dendrites","Martin Harterink","The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal polarity that allows for selective cargo sorting. However, how dendritic microtubules are organized and whether local differences influence cargo transport remains largely unknown. Here, we use live-cell imaging to systematically probe the microtubule organization in \u003Ci>Caenorhabditis\u003C\u002Fi>\u003Ci>elegans\u003C\u002Fi> neurons, and demonstrate the contribution of distin",{"id":129,"funder":7,"programme":8,"title":130,"piName":131,"institution":132,"country":12,"year":13,"amount":14,"abstract":133},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-001-002","Alpha-amylase reactivity and recovery patterns in anhedonic young adults performing a tandem skydive","Charlotte Vrijen","University Medical Center Groningen","Alpha-amylase patterns following a tandem skydive in anhedonic individuals are highly similar to patterns previously found in healthy individuals. Although replication is warranted, our findings tentatively suggest that a strong stress response that cannot be downregulated well predicts a decrease in self-esteem.",{"id":135,"funder":7,"programme":8,"title":136,"piName":137,"institution":37,"country":12,"year":13,"amount":14,"abstract":138},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-160-613","Structure and function of archaeal histones","Remus T. Dame","The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes. Post-translational modifications of the histones, which occur mostly on their N-terminal tails, define the functional state of chromatin. Like eukaryotes, most archaeal genomes encode histones, which are believed to be involved in the compaction and organiz",{"id":140,"funder":7,"programme":8,"title":141,"piName":142,"institution":143,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-453-07-001","A clinical interpretation of shame regulation in maladaptive perfectionism","Frans Schalkwijk","Netherlands Youth Institute",{"id":145,"funder":7,"programme":8,"title":146,"piName":147,"institution":148,"country":12,"year":13,"amount":14,"abstract":149},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-016-130-627","Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism","Fred van Leeuwen","The Netherlands Cancer Institute","The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by monoubiquitination of the C-terminus of histone H2B (H2Bub1). To gain more insight into the functions of Dot1, we generated genetic interaction maps of increased-dosage alleles of DOT1. We identified a functional relationship between increased Dot1 dosa",{"id":151,"funder":7,"programme":8,"title":152,"piName":153,"institution":154,"country":12,"year":13,"amount":14,"abstract":155},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-2002406","The effect of haemodynamic and peripheral vascular variability on cardiac output monitoring: thermodilution and non‐invasive pulse contour cardiac output during cardiothoracic surgery","Johannes J. van Lieshout","Academic Medical Center","While haemodynamic variability interferes with the assumption of constant flow underlying thermodilution cardiac output calculation, variability in (peripheral) arterial vascular physiology may affect pulse contour cardiac output methods. We compared non-invasive finger arterial pressure-derived continuous cardiac output measurements (Nexfin\u003Csup>®\u003C\u002Fsup> ) with cardiac output measured using thermodilution during cardiothoracic surgery and determined the impact of cardiovascular variability on eit",{"id":157,"funder":7,"programme":8,"title":158,"piName":159,"institution":49,"country":12,"year":13,"amount":14,"abstract":160},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-865-11-001","Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM","Dirk Jan Slotboom","Uptake of vitamin B12 is essential for many prokaryotes, but in most cases the membrane proteins involved are yet to be identified. We present the biochemical characterization and high-resolution crystal structure of BtuM, a predicted bacterial vitamin B12 uptake system. BtuM binds vitamin B12 in its base-off conformation, with a cysteine residue as axial ligand of the corrin cobalt ion. Spectroscopic analysis indicates that the unusual thiolate coordination allows for decyanation of vitamin B12",{"id":162,"funder":7,"programme":8,"title":163,"piName":164,"institution":31,"country":12,"year":13,"amount":14,"abstract":165},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-91812628","ACBD3 is an essential pan-enterovirus host factor that mediates the interaction between viral 3A protein and cellular protein PI4KB","Frank J. M. van Kuppeveld","Abstract The enterovirus genus of the picornavirus family includes a large number of important human pathogens such as poliovirus, coxsackievirus, enterovirus-A71, and rhinoviruses. Like all other positive-strand RNA viruses, genome replication of enteroviruses occurs on rearranged membranous structures called replication organelles (ROs). Phosphatidylinositol 4-kinase IIIβ (PI4KB) is required by all enteroviruses for RO formation. The enteroviral 3A protein recruits PI4KB to ROs, but the exact ",{"id":167,"funder":7,"programme":8,"title":163,"piName":164,"institution":31,"country":12,"year":13,"amount":14,"abstract":165},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-91812628",{"id":169,"funder":7,"programme":8,"title":170,"piName":171,"institution":20,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-639-033-413","Fluid flow models in performance analysis","Onno Boxma",{"id":173,"funder":7,"programme":8,"title":170,"piName":171,"institution":20,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-grant-639-033-413",{"id":175,"funder":7,"programme":8,"title":176,"piName":177,"institution":31,"country":12,"year":13,"amount":14,"abstract":178},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vici","APC2 controls dendrite development by promoting microtubule dynamics","Olga I. Kahn","Mixed polarity microtubule organization is the signature characteristic of vertebrate dendrites. Oppositely oriented microtubules form the basis for selective cargo trafficking in neurons, however the mechanisms that establish and maintain this organization are unclear. Here, we show that APC2, the brain-specific homolog of tumor-suppressor protein adenomatous polyposis coli (APC), promotes dynamics of minus-end-out microtubules in dendrites. We found that APC2 localizes as distinct clusters alo",{"id":180,"funder":7,"programme":8,"title":176,"piName":177,"institution":31,"country":12,"year":13,"amount":14,"abstract":178},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vici",{"id":182,"funder":7,"programme":8,"title":183,"piName":184,"institution":185,"country":12,"year":13,"amount":14,"abstract":186},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-130-668","Magnesium deficiency prevents high-fat-diet-induced obesity in mice","Steef Kurstjens","Radboud University Nijmegen","Mg\u003Csup>2+\u003C\u002Fsup>-deficiency abrogates HFD-induced obesity in mice through enhanced eWAT lipolysis and BAT activity.",{"id":188,"funder":7,"programme":8,"title":189,"piName":190,"institution":191,"country":12,"year":13,"amount":14,"abstract":192},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-639-033-413","Emergent Failures and Cascades in Power Grids: A Statistical Physics Perspective","Tommaso Nesti","Centrum Wiskunde & Informatica","We model power grids transporting electricity generated by intermittent renewable sources as complex networks, where line failures can emerge indirectly by noisy power input at the nodes. By combining concepts from statistical physics and the physics of power flows and taking weather correlations into account, we rank line failures according to their likelihood and establish the most likely way such failures occur and propagate. Our insights are mathematically rigorous in a small-noise limit and",{"id":194,"funder":7,"programme":8,"title":195,"piName":196,"institution":197,"country":198,"year":13,"amount":14,"abstract":199},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-639-043-107","Medium-resolution integral-field spectroscopy for high-contrast exoplanet imaging","H. J. Hoeijmakers","University of Bern","CH","Context. Angular differential imaging (ADI) and spectral differential imaging (SDI) are well-established high-contrast imaging techniques, but their application is challenging for companions at small angular separations from their host stars. Aims. The aim of this paper is to investigate to what extent adaptive-optics assisted, medium-resolution ( R ~ 5000) integral field spectrographs (IFS) can be used to directly detect the absorption of molecular species in the spectra of planets and substell",{"id":201,"funder":7,"programme":8,"title":202,"piName":203,"institution":204,"country":92,"year":13,"amount":14,"abstract":205},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-865-12-005","SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium","Rui Chen","Baylor College of Medicine","Photoreceptor-specific ciliopathies often affect a structure that is considered functionally homologous to the ciliary transition zone (TZ) called the connecting cilium (CC). However, it is unclear how mutations in certain ciliary genes disrupt the photoreceptor CC without impacting the primary cilia systemically. By applying stochastic optical reconstruction microscopy technology in different genetic models, we show that the CC can be partitioned into two regions: the proximal CC (PCC), which i",{"id":207,"funder":7,"programme":8,"title":208,"piName":209,"institution":132,"country":12,"year":13,"amount":14,"abstract":210},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-111","Effect of frequency mismatch and band partitioning on vocal tract length perception in vocoder simulations of cochlear implant processing","Nawal El Boghdady","The vocal tract length (VTL) of a speaker is an important voice cue that aids speech intelligibility in multi-talker situations. However, cochlear implant (CI) users demonstrate poor VTL sensitivity. This may be partially caused by the mismatch between frequencies received by the implant and those corresponding to places of stimulation along the cochlea. This mismatch can distort formant spacing, where VTL cues are encoded. In this study, the effects of frequency mismatch and band partitioning o",{"id":212,"funder":7,"programme":8,"title":213,"piName":214,"institution":215,"country":12,"year":13,"amount":14,"abstract":216},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-cw-vici-project-016-122-613","Porphyrin Co(III)-Nitrene Radical Mediated Pathway for Synthesis of o-Aminoazobenzenes","Bas de Bruin","Institute for Atomic and Molecular Physics","Azobenzenes are versatile compounds with a range of applications, including dyes and pigments, food additives, indicators, radical reaction initiators, molecular switches, etc. In this context, we report a general method for synthesizing \u003Ci>o\u003C\u002Fi>-aminoazobenzenes using the commercially available cobalt(II) tetraphenyl porphyrin \u003Cb>[Co\u003Csup>II\u003C\u002Fsup>(TPP)]\u003C\u002Fb>. The net reaction is a formal dimerization of two phenyl azides with concomitant loss of two molecules of dinitrogen. The most commonly used",{"id":218,"funder":7,"programme":8,"title":219,"piName":220,"institution":11,"country":12,"year":13,"amount":14,"abstract":221},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-016-140-657","The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth","Raimond Heukers","Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28, have been detected in GBM tumors. US28 displays constitutive activity and is able to bind several human chemokines, leading to the activation of various proliferative and inflammatory signaling pathways. Here we show that HCMV, through the expression of US28, significantly enhanced the growth of 3D spheroids of U251- and ne",{"id":223,"funder":7,"programme":8,"title":224,"piName":225,"institution":11,"country":12,"year":13,"amount":14,"abstract":226},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-number-865-12-003","Gene regulatory mechanisms underlying the evolutionary loss of a polygenic trait","Mark Lammers","Abstract Trait loss is a pervasive phenomenon in evolution, yet the underlying molecular causes have been identified in only a handful of cases. Most of these involve loss-of-function mutations in one or more trait-specific genes. Parasitoid insects are fatty acid auxotrophs: they lost the ability to convert dietary sugars into fatty acids, a trait that is ubiquitous among non-parasitoid animals and is enabled by a highly conserved set of genes. Earlier research suggests that lack of lipogenesis",{"id":228,"funder":7,"programme":8,"title":229,"piName":230,"institution":31,"country":12,"year":13,"amount":14,"abstract":231},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-2012","Steering particles by breaking symmetries","Bram Bet","We derive general equations of motions for highly-confined particles that perform quasi-two-dimensional motion in Hele-Shaw channels, which we solve analytically, aiming to derive design principles for self-steering particles. Based on symmetry properties of a particle, its equations of motion can be simplified, where we retrieve an earlier-known equation of motion for the orientation of dimer particles consisting of disks (Uspal et al 2013 Nat. Commun. 4), but now in full generality. Subsequent",{"id":233,"funder":7,"programme":8,"title":234,"piName":235,"institution":185,"country":12,"year":13,"amount":14,"abstract":236},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-11-001","Active Braking of Whole-Arm Reaching Movements Provides Single-Trial Neuromuscular Measures of Movement Cancellation","Jeroen Atsma","Movement inhibition is an aspect of executive control that can be studied using the countermanding paradigm, wherein subjects try to cancel an impending movement following presentation of a stop signal. This paradigm permits estimation of the stop-signal reaction time or the time needed to respond to the stop signal. Numerous countermanding studies have examined fast, ballistic movements, such as saccades, even though many movements in daily life are not ballistic and can be stopped at any point",{"id":238,"funder":7,"programme":8,"title":239,"piName":240,"institution":31,"country":12,"year":13,"amount":14,"abstract":241},"openalex-nederlandse-organisatie-voor-wetenschapp-award-stw-vici-016-140-316-13710","Location and probability of shoal margin collapses in a sandy estuary","W. M. van Dijk","Abstract Channel bank failure, and collapses of shoal margins and beaches due to flow slides, have been recorded in Dutch estuaries for the past 200 years but have hardly been recognized elsewhere. Current predictions lack forecasting capabilities, because they were validated and calibrated for historic data of cross‐sections in specific systems, allowing local hindcast rather than location and probability forecasting. The objectives of this study were to investigate where on shoal margins colla",{"id":243,"funder":7,"programme":8,"title":244,"piName":214,"institution":55,"country":12,"year":13,"amount":14,"abstract":245},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-cw-vici","Mechanistic investigations into the cyclopropanation of electron-deficient alkenes with ethyl diazoacetate using [Co(MeTAA)]","A detailed mechanistic study of the cyclopropanation of electron-deficient alkenes, namely methyl acrylate with ethyl diazoacetate (EDA), was carried out, aiming at understanding both the superior activity and the higher sensitivity of the cobalt(II) tetramethyldibenzotetraaza[14]annulene [Co(MeTAA)] catalyst as compared with cobalt(II) tetraphenylporphyrin [Co(TPP)]. Cobalt(III)-carbene radicals were demonstrated to be present as key intermediates in the reaction, using a combination of kinetic",{"id":247,"funder":7,"programme":8,"title":248,"piName":249,"institution":154,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-918-10-619","DDX3 in HIV-1 infection and sensing: A paradox","Sonja I. Gringhuis",{"id":251,"funder":7,"programme":8,"title":252,"piName":253,"institution":185,"country":12,"year":13,"amount":14,"abstract":254},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-865-12-005","Cellular ciliary phenotyping indicates pathogenicity of novel variants in IFT140 and confirms a Mainzer–Saldino syndrome diagnosis","Machteld M. Oud","By combining the clinical, genetic, and functional data from this study, we could conclude that the patient has SRTD9, also called Mainzer-Saldino syndrome, caused by variants in \u003Ci>IFT140\u003C\u002Fi>. We suggest the possibility that variants in \u003Ci>IFT140\u003C\u002Fi> may underlie hearing impairment. Moreover, we show that urine provides an excellent source to obtain patient-derived cells in a non-invasive manner to study the pathogenicity of variants detected by genetic testing.",{"id":256,"funder":7,"programme":8,"title":257,"piName":258,"institution":215,"country":12,"year":13,"amount":14,"abstract":259},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-project-016-122-613","[Co(MeTAA)] Metalloradical Catalytic Route to Ketenes via Carbonylation of Carbene Radicals","Andrei Chirila","An efficient synthetic strategy towards beta‐lactams, amides, and esters involving “in situ” generation of ketenes and subsequent trapping with nucleophiles is presented. Carbonylation of carbene radical intermediates using the cheap and highly active cobalt(II) tetramethyltetraaza[14]annulene catalyst [Co(MeTAA)] provides a convenient one‐pot synthetic protocol towards substituted ketenes. N ‐tosylhydrazones are used as carbene precursors, thereby bridging the gap between aldehydes and ketenes.",{"id":261,"funder":7,"programme":8,"title":262,"piName":263,"institution":55,"country":12,"year":13,"amount":14,"abstract":264},"openalex-nederlandse-organisatie-voor-wetenschapp-award-12128-vici","The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity","Michaela Wenzel","The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resoluti",{"id":266,"funder":7,"programme":8,"title":267,"piName":268,"institution":37,"country":12,"year":13,"amount":14,"abstract":269},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-14-001-e-a-c-","Media use and brain development during adolescence","Eveline A. Crone","The current generation of adolescents grows up in a media-saturated world. However, it is unclear how media influences the maturational trajectories of brain regions involved in social interactions. Here we review the neural development in adolescence and show how neuroscience can provide a deeper understanding of developmental sensitivities related to adolescents' media use. We argue that adolescents are highly sensitive to acceptance and rejection through social media, and that their heightene",{"id":271,"funder":7,"programme":8,"title":272,"piName":273,"institution":274,"country":12,"year":13,"amount":14,"abstract":275},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-918-14-655","Clinically-Applicable Perfluorocarbon-Loaded Nanoparticles For \u003Ci>In vivo\u003C\u002Fi> Photoacoustic, \u003Csup>19\u003C\u002Fsup>F Magnetic Resonance And Fluorescent Imaging","Mangala Srinivas","Radboud University Medical Center","Photoacoustic imaging (PAI) is an emerging biomedical imaging technique that is now coming to the clinic. It has a penetration depth of a few centimeters and generates useful endogenous contrast, particularly from melanin and oxy-\u002Fdeoxyhemoglobin. Indocyanine green (ICG) is a Food and Drug Administration-approved contrast agents for human applications, which can be also used in PAI. It is a small molecule dye with limited applications due to its fast clearance, rapid protein binding, and bleachi",{"id":277,"funder":7,"programme":8,"title":272,"piName":273,"institution":274,"country":12,"year":13,"amount":14,"abstract":275},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-918-14-655",{"id":279,"funder":7,"programme":8,"title":280,"piName":281,"institution":282,"country":92,"year":13,"amount":14,"abstract":283},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-724-011-002","Competition between salt bridge and non-zwitterionic structures in deprotonated amino acid dimers","Sven Heiles","Berkeley College","Structures of deprotonated Cys, Asp, Glu, Phe, Pro, His homo dimers as well as [2Cys - 3H]-, [Asp + Glu - H]- and [2Glu - 2H + Na]- are investigated with infrared multiple-photon dissociation (IRMPD) spectroscopy between 650 and 1850 cm-1 and theory. The IRMPD spectra of all investigated complexes but [2His - H]-, [2Phe - H]- and [2Pro - H]- indicate that the structures consist of a neutral non-zwitterionic (NZ) and a deprotonated form of the amino acids. In contrast, the spectrum of [2His - H]-",{"id":285,"funder":7,"programme":8,"title":286,"piName":287,"institution":288,"country":12,"year":13,"amount":14,"abstract":289},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-724-013-002","Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation","Huib Ovaa","Leiden University Medical Center","The development of γ-thionorleucine (ThioNle) as a handle for native chemical ligation-desulfurization is reported here. ThioNle is a new addition to the expanding thiolated amino acid toolbox and serves as a methionine substitute in NCL with the advantage that it lacks the undesirable oxidation-prone thioether moiety. Its usefulness for N-terminal ubiquitination is demonstrated by efficient preparation of fully synthetic linear diubiquitin with preserved protein folding compared to the expresse",{"id":291,"funder":7,"programme":8,"title":292,"piName":293,"institution":294,"country":295,"year":13,"amount":14,"abstract":296},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-nwo-86514007","Nuclear arms races: Experimental evolution for mating success in the mushroom-forming fungus Schizophyllum commune","Bart Nieuwenhuis","Ludwig-Maximilians-Universität München","DE","When many gametes compete to fertilize a limited number of compatible gametes, sexual selection will favour traits that increase competitive success during mating. In animals and plants, sperm and pollen competition have yielded many interesting adaptations for improved mating success. In fungi, similar processes have not been shown directly yet. We test the hypothesis that sexual selection can increase competitive fitness during mating, using experimental evolution in the mushroom-forming fungu",{"id":298,"funder":7,"programme":8,"title":299,"piName":300,"institution":301,"country":12,"year":13,"amount":14,"abstract":302},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-project-no-865-14-003","Visualization and Quantification of Cell-to-cell Movement of Proteins in Nicotiana benthamiana","Frank L. W. Takken","Netherlands Institute for Neuroscience","Cell-to-cell movement of proteins through plasmodesmata is a widely-established mechanism for intercellular signaling in plants. Current techniques to study intercellular protein translocation rely on single-cell transformation using particle bombardment or transgenic lines expressing photo-inducible fluorophores. The method presented here allows visualization and objective quantification of (effector) protein movement between \u003Ci>N. benthamiana\u003C\u002Fi> leaf cells. Agroinfiltration is performed using",{"id":304,"funder":7,"programme":8,"title":305,"piName":306,"institution":307,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-639-023-710","Program Correctness by Transformation","Marieke Huisman","University of Twente",{"id":309,"funder":7,"programme":8,"title":35,"piName":310,"institution":37,"country":12,"year":13,"amount":14,"abstract":38},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-639-043-512","Christos Georgiou",{"id":312,"funder":7,"programme":8,"title":313,"piName":314,"institution":49,"country":12,"year":13,"amount":14,"abstract":315},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-724-013-003","Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid","Clemens Mayer","The impressive rate accelerations that enzymes display in nature often result from boosting the inherent catalytic activities of side chains by their precise positioning inside a protein binding pocket. Such fine-tuning is also possible for catalytic unnatural amino acids. Specifically, the directed evolution of a recently described designer enzyme, which utilizes an aniline side chain to promote a model hydrazone formation reaction, is reported. Consecutive rounds of directed evolution identifi",{"id":317,"funder":7,"programme":8,"title":318,"piName":319,"institution":14,"country":14,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-916-96-628","Stability of end-of-life preferences in relation to health status and life-events: A cohort study with a 6-year follow-up among holders of an advance directive","Matthijs P S van Wijmen","Our results largely dispute criticism concerning usability of advance directives due to lack of stability of preferences. Whereas a change in health status and the experience of other life-events were not related to instability in preferences, they did increase the odds of communication about advance directives. Because our results show that the possession of an advance directive does not necessarily result in frequent discussions between patients and caregivers, a more structured approach like ",{"id":322,"funder":7,"programme":8,"title":318,"piName":319,"institution":14,"country":14,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-916-96-628",{"id":324,"funder":7,"programme":8,"title":325,"piName":326,"institution":67,"country":12,"year":13,"amount":14,"abstract":327},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vici-016-150-673-865-14-002","Stress vulnerability promotes an alcohol‐prone phenotype in a preclinical model of sustained depression","Danai Riga","Major depression and alcohol-related disorders frequently co-occur. Depression severity weighs on the magnitude and persistence of comorbid alcohol use disorder (AUD), with severe implications for disease prognosis. Here, we investigated whether depression vulnerability drives propensity to AUD at the preclinical level. We used the social defeat-induced persistent stress (SDPS) model of chronic depression in combination with operant alcohol self-administration (SA). Male Wistar rats were subject",{"id":329,"funder":7,"programme":8,"title":330,"piName":331,"institution":11,"country":12,"year":13,"amount":14,"abstract":332},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-865-12-003","Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis","Ken Kraaijeveld","Taken together, our results reveal how specific cognitive abilities can readily respond to selection via a complex interplay between regulatory and sequence evolution.",65,{"programme":8,"total":335,"withPiName":335,"firstYear":336,"lastYear":337,"countryCount":338,"perYear":339,"topInstitutions":384,"topCountries":425},296,2008,2026,18,[340,342,344,346,349,352,355,358,361,362,365,367,370,373,376,379,382],{"year":336,"count":341},1,{"year":343,"count":341},2011,{"year":345,"count":341},2012,{"year":347,"count":348},2013,3,{"year":350,"count":351},2014,4,{"year":353,"count":354},2015,7,{"year":356,"count":357},2016,14,{"year":359,"count":360},2017,44,{"year":13,"count":333},{"year":363,"count":364},2019,9,{"year":366,"count":338},2020,{"year":368,"count":369},2021,16,{"year":371,"count":372},2022,22,{"year":374,"count":375},2023,27,{"year":377,"count":378},2024,26,{"year":380,"count":381},2025,23,{"year":337,"count":383},15,[385,387,389,390,391,393,394,396,397,399,401,403,405,406,408,409,410,412,414,415,417,419,421,422,423],{"name":31,"count":386},40,{"name":185,"count":388},24,{"name":37,"count":372},{"name":55,"count":372},{"name":11,"count":392},20,{"name":20,"count":383},{"name":132,"count":395},13,{"name":49,"count":354},{"name":67,"count":398},6,{"name":400,"count":398},"Erasmus MC",{"name":402,"count":398},"University Medical Center Utrecht",{"name":301,"count":404},5,{"name":307,"count":404},{"name":407,"count":351},"Delft University of Technology",{"name":215,"count":351},{"name":288,"count":351},{"name":411,"count":351},"Wageningen University & Research",{"name":413,"count":348},"Broad Institute",{"name":148,"count":348},{"name":154,"count":416},2,{"name":418,"count":416},"Amsterdam UMC Location University of Amsterdam",{"name":420,"count":416},"Maastricht University",{"name":61,"count":416},{"name":274,"count":416},{"name":424,"count":416},"Tilburg University",[426,428,430,431,433,434,436,438,440,442,444,446,448,450,452,454,456,458],{"name":12,"count":427},234,{"name":92,"count":429},17,{"name":295,"count":404},{"name":432,"count":351},"GB",{"name":198,"count":348},{"name":435,"count":348},"IT",{"name":437,"count":416},"CA",{"name":439,"count":416},"ZA",{"name":441,"count":341},"AT",{"name":443,"count":341},"AU",{"name":445,"count":341},"BE",{"name":447,"count":341},"BR",{"name":449,"count":341},"CN",{"name":451,"count":341},"CZ",{"name":453,"count":341},"IE",{"name":455,"count":341},"QA",{"name":457,"count":341},"RU",{"name":459,"count":341},"TH"]