[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2020":3,"awarded-stats-nwo-vici":117},{"awarded":4,"total":116},[5,16,22,27,33,39,45,52,59,66,71,77,82,89,95,100,105,110],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-680-47-621-","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Strong Coupling to Generate Complex Birefringence: Metasurface in the Middle Etalons","A. Femius Koenderink","Institute for Atomic and Molecular Physics","NL",2020,null,"High Resolution Image Download MS PowerPoint Slide We have measured the optical signatures of strong coupling between the resonance of etalons and plasmon antenna arrays in transmission and polarization. Planar etalons in the middle of which a plasmon antenna array is placed show anticrossings in transmission between the etalon resonances and plasmon antenna resonance, which we map as a function of frequency, etalon opening and oscillator strengh. We argue that the proper interpretation of stron",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-12128","Control of septum thickness by the curvature of SepF polymers","Michaela Wenzel","University of Amsterdam","Significance Many bacteria form a thick cell wall and divide by forming a cross wall. How they control the thickness of their cell wall and cross wall is unknown. In this study, we show that in these bacteria the cell division protein SepF forms very large protein rings with diameters that correspond to the diameter of their cross walls. Importantly, when we changed the diameter of SepF rings in the bacterial host Bacillus subtilis , the thickness of its cross wall changed accordingly. These res",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":14,"country":14,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-865-17-001","Eocene intra-plate shortening responsible for the rise of a faunal pathway in the northeastern Caribbean realm","with the GARANTI Team","Intriguing latest Eocene land-faunal dispersals between South America and the Greater Antilles (northern Caribbean) has inspired the hypothesis of the GAARlandia (Greater Antilles Aves Ridge) land bridge. This landbridge, however, should have crossed the Caribbean oceanic plate, and the geological evolution of its rise and demise, or its geodynamic forcing, remain unknown. Here we present the results of a land-sea survey from the northeast Caribbean plate, combined with chronostratigraphic data,",{"id":28,"funder":7,"programme":8,"title":29,"piName":30,"institution":31,"country":12,"year":13,"amount":14,"abstract":32},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-nr-865-17-002","The bHLH network underlying plant shade‐avoidance","Ronald Pierik","Utrecht University","Shade is a potential threat to many plant species. When shade-intolerant plants detect neighbours, they elongate their stems and leaves in an effort to maximise their light capture. This developmental programme, known as 'shade-avoidance' is tightly controlled by specialised photoreceptors and a suite of transcriptional regulators. The basic helix-loop-helix (bHLH) family of transcription factors are particularly important for shade-induced elongation. In recent years, it has become apparent tha",{"id":34,"funder":7,"programme":8,"title":35,"piName":36,"institution":37,"country":12,"year":13,"amount":14,"abstract":38},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-no-91812607","Social Needs and Happiness: A Life Course Perspective","Vera L. Buijs","University of Groningen","Abstract Both the fulfilment of affection, status, and behavioral confirmation needs and their role in happiness may differ along the adult lifespan. We examined age-graded differences in (a) the fulfilment of the need for affection, status, and behavioral confirmation, (b) disharmonious profiles of need fulfillment (e.g., high affection but low status), and (c) the associations between these needs and happiness. Data from 11,406 Dutch respondents (age range 18–87 ( M = 44.82, SD = 14.62), 67% f",{"id":40,"funder":7,"programme":8,"title":41,"piName":42,"institution":43,"country":12,"year":13,"amount":14,"abstract":44},"openalex-nederlandse-organisatie-voor-wetenschapp-award-916-14-655-vici-","EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer","Wouter P. R. Verdurmen","Radboud University Nijmegen","Ovarian cancer is the most lethal gynecological malignancy due to late detection associated with dissemination throughout the abdominal cavity. Targeted photodynamic therapy (tPDT) aimed at epithelial cell adhesion molecule (EpCAM), overexpressed in over 90% of ovarian cancer metastatic lesions, is a promising novel therapeutic modality. Here, we tested the specificity and activity of conjugates of EpCAM-directed designed ankyrin repeat proteins (DARPins) with the photosensitizer IRDye 700DX in ",{"id":46,"funder":7,"programme":8,"title":47,"piName":48,"institution":49,"country":50,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-project-nr-016-160-351","Supporting measurements or more averages? How to quantify cerebral blood flow most reliably in 5 minutes by arterial spin labeling","Piet Bladt","University of Antwerp","BE","Purpose To determine whether sacrificing part of the scan time of pseudo‐continuous arterial spin labeling (PCASL) for measurement of the labeling efficiency and blood is beneficial in terms of CBF quantification reliability. Methods In a simulation framework, 5‐minute scan protocols with different scan time divisions between PCASL data acquisition and supporting measurements were evaluated in terms of CBF estimation variability across both noise and ground truth parameter realizations taken fro",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":56,"country":57,"year":13,"amount":14,"abstract":58},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-724-014-003","Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids","Wuyuan Zhang","Xi'an Jiaotong University","CN","En route to a bio-based chemical industry, the conversion of fatty acids into building blocks is of particular interest. Enzymatic routes, occurring under mild conditions and excelling by intrinsic selectivity, are particularly attractive. Here we report photoenzymatic cascade reactions to transform unsaturated fatty acids into enantiomerically pure secondary fatty alcohols. In a first step the C=C-double bond is stereoselectively hydrated using oleate hydratases from Lactobacillus reuteri or St",{"id":60,"funder":7,"programme":8,"title":61,"piName":62,"institution":63,"country":64,"year":13,"amount":14,"abstract":65},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-724-014-003","Biocatalytic Reduction Reactions from a Chemist's Perspective","Frank Hollmann","University of the Free State","ZA","Reductions play a key role in organic synthesis, producing chiral products with new functionalities. Enzymes can catalyse such reactions with exquisite stereo-, regio- and chemoselectivity, leading the way to alternative shorter classical synthetic routes towards not only high-added-value compounds but also bulk chemicals. In this review we describe the synthetic state-of-the-art and potential of enzymes that catalyse reductions, ranging from carbonyl, enone and aromatic reductions to reductive ",{"id":67,"funder":7,"programme":8,"title":68,"piName":69,"institution":31,"country":12,"year":13,"amount":14,"abstract":70},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-vi-c-182-027","Prophages are associated with extensive CRISPR–Cas auto-immunity","Bas E. Dutilh","CRISPR-Cas systems require discriminating self from non-self DNA during adaptation and interference. Yet, multiple cases have been reported of bacteria containing self-targeting spacers (STS), i.e. CRISPR spacers targeting protospacers on the same genome. STS has been suggested to reflect potential auto-immunity as an unwanted side effect of CRISPR-Cas defense, or a regulatory mechanism for gene expression. Here we investigated the incidence, distribution, and evasion of STS in over 100 000 bact",{"id":72,"funder":7,"programme":8,"title":73,"piName":74,"institution":75,"country":12,"year":13,"amount":14,"abstract":76},"openalex-nederlandse-organisatie-voor-wetenschapp-award-enw-groot-topcore-vici-grant-680-47-625-","Artificial oxide heterostructures with non-trivial topology","Pieter M Gunnink","University of Twente","In the quest for topological insulators with large band gaps, heterostructures with Rashba spin-orbit interactions come into play. Transition metal oxides with heavy ions are especially interesting in this respect. We discuss the design principles for stacking oxide Rashba layers. Assuming a single layer with a two-dimensional electron gas (2DEG) on both interfaces as a building block, a two-dimensional topological insulating phase is present when negative coupling between the 2DEGs exists. When",{"id":78,"funder":7,"programme":8,"title":79,"piName":80,"institution":81,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-grant-639033109","The parameterization method for center manifolds","Bob Rink","Vrije Universiteit Amsterdam",{"id":83,"funder":7,"programme":8,"title":84,"piName":85,"institution":86,"country":87,"year":13,"amount":14,"abstract":88},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-13708","Tuning the reactivity of molybdenum (oxy)carbide catalysts by the carburization degree: CO\u003Csub>2\u003C\u002Fsub> reduction and anisole hydrodeoxygenation","Nikolay Kosinov","Institute of Catalysis and Petrochemistry","RU","Structure-performance relations for molybdenum (oxy)carbide catalysts evaluated for CO\u003Csub>2\u003C\u002Fsub> hydrogenation and anisole hydrodeoxygenation.",{"id":90,"funder":7,"programme":8,"title":91,"piName":92,"institution":93,"country":12,"year":13,"amount":14,"abstract":94},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-91818627","Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice","Marit J. van Gils","Amsterdam University Medical Centers","neutralization sensitivity of the viruses to PGDM1400. As expected for monotherapy, viral loads rebounded after about a week and different viral escape pathways were observed, involving the deletion of glycans in the envelope glycoprotein at positions 130 or 160. (Pre)clinical trials should reveal whether PGDM1400 is a useful component of an antibody combination treatment or as part of a tri-specific antibody.",{"id":96,"funder":7,"programme":8,"title":97,"piName":98,"institution":43,"country":12,"year":13,"amount":14,"abstract":99},"openalex-nederlandse-organisatie-voor-wetenschapp-award-724-011-002-vici-","Vibrational Spectra of the Ruthenium–Tris-Bipyridine Dication and Its Reduced Form in Vacuo","Jos Oomens","is delocalized over the three bpy ligands, while the long-range corrected LC-BLYP and the CAM-B3LYP functionals show it to be more localized on a single bpy ligand. Although these latter levels of theory fail to reproduce the experimentally observed IR frequencies, one may argue that the unusually large bandwidths observed in the spectrum are due to the fluxional character of a complex with the added electron not symmetrically distributed over the ligands. The experimental IR spectra presented h",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":20,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-016-vici-170-083-","Laypeople Can Predict Which Social-Science Studies Will Be Replicated Successfully","Suzanne Hoogeveen","Large-scale collaborative projects recently demonstrated that several key findings from the social-science literature could not be replicated successfully. Here, we assess the extent to which a finding’s replication success relates to its intuitive plausibility. Each of 27 high-profile social-science findings was evaluated by 233 people without a Ph.D. in psychology. Results showed that these laypeople predicted replication success with above-chance accuracy (i.e., 59%). In addition, when partic",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":31,"country":12,"year":13,"amount":14,"abstract":109},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-453-14-014-","Signals in the Waves of Surf: Category Development and Signals in Surf Music","Matthijs B. Punt","The aim of this paper is to investigate to what extent the understanding of market categories changes over time and how this is reflected in the importance of different category signals in periods of category maturation and revival. We test the changing influence of different types of category signals on inclusion rates of surf music compilation albums, which represent the understanding of “surf music” from a market-based perspective. We find that “elaborate” signals to the category label of sur",{"id":111,"funder":7,"programme":8,"title":112,"piName":113,"institution":114,"country":12,"year":13,"amount":14,"abstract":115},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-91815604","RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer","Madelon M. Maurice","University Medical Center Utrecht","Wnt\u002Fβ-catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt-hypersensitive tumors that are susceptible to anti-Wnt-based therapy. Contrary to this paradigm, we identify a class of RNF43 truncating cancer mutations that induce β-catenin-mediated transcription, despite exhibiting retained Wnt receptor downregulation. These mut",18,{"programme":8,"total":118,"withPiName":118,"firstYear":119,"lastYear":120,"countryCount":116,"perYear":121,"topInstitutions":167,"topCountries":217},296,2008,2026,[122,124,126,128,131,134,137,140,143,146,149,150,153,156,159,162,165],{"year":119,"count":123},1,{"year":125,"count":123},2011,{"year":127,"count":123},2012,{"year":129,"count":130},2013,3,{"year":132,"count":133},2014,4,{"year":135,"count":136},2015,7,{"year":138,"count":139},2016,14,{"year":141,"count":142},2017,44,{"year":144,"count":145},2018,65,{"year":147,"count":148},2019,9,{"year":13,"count":116},{"year":151,"count":152},2021,16,{"year":154,"count":155},2022,22,{"year":157,"count":158},2023,27,{"year":160,"count":161},2024,26,{"year":163,"count":164},2025,23,{"year":120,"count":166},15,[168,170,172,174,175,177,179,182,183,186,188,189,192,193,195,196,198,200,202,204,207,209,211,213,215],{"name":31,"count":169},40,{"name":43,"count":171},24,{"name":173,"count":155},"Leiden University",{"name":20,"count":155},{"name":81,"count":176},20,{"name":178,"count":166},"Eindhoven University of Technology",{"name":180,"count":181},"University Medical Center Groningen",13,{"name":37,"count":136},{"name":184,"count":185},"Amsterdam Neuroscience",6,{"name":187,"count":185},"Erasmus MC",{"name":114,"count":185},{"name":190,"count":191},"Netherlands Institute for Neuroscience",5,{"name":75,"count":191},{"name":194,"count":133},"Delft University of Technology",{"name":11,"count":133},{"name":197,"count":133},"Leiden University Medical Center",{"name":199,"count":133},"Wageningen University & Research",{"name":201,"count":130},"Broad Institute",{"name":203,"count":130},"The Netherlands Cancer Institute",{"name":205,"count":206},"Academic Medical Center",2,{"name":208,"count":206},"Amsterdam UMC Location University of Amsterdam",{"name":210,"count":206},"Maastricht University",{"name":212,"count":206},"Oncode Institute",{"name":214,"count":206},"Radboud University Medical Center",{"name":216,"count":206},"Tilburg University",[218,220,223,225,227,229,231,233,234,236,238,239,241,242,244,246,248,249],{"name":12,"count":219},234,{"name":221,"count":222},"US",17,{"name":224,"count":191},"DE",{"name":226,"count":133},"GB",{"name":228,"count":130},"CH",{"name":230,"count":130},"IT",{"name":232,"count":206},"CA",{"name":64,"count":206},{"name":235,"count":123},"AT",{"name":237,"count":123},"AU",{"name":50,"count":123},{"name":240,"count":123},"BR",{"name":57,"count":123},{"name":243,"count":123},"CZ",{"name":245,"count":123},"IE",{"name":247,"count":123},"QA",{"name":87,"count":123},{"name":250,"count":123},"TH"]