[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2021":3,"awarded-stats-nwo-vici":98},{"awarded":4,"total":97},[5,16,22,29,35,40,46,52,57,62,67,72,74,80,86,92],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-724-011-002-ttw-15769-tki-lift-731-017-419-rekentijd-2019-062","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy","Jonathan Martens","HFML-FELIX","NL",2021,null,"BackgroundPyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to deficiency of α-aminoadipic semialdehyde dehydrogenase\u002Fantiquitin, resulting in accumulation of piperideine-6-carboxylate (P6C), and secondary deficiency of the important cofactor pyridoxal-5'-phosphate (PLP, active vitamin B6) through its complexation with P6C. Vitamin B6 supplementation resolves epilepsy in patients",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-45316004","Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch","Stefanie H. Meeuwis","Leiden University","Introduction: Placebo and nocebo effects are positive and negative health outcomes that can be elicited by the psychosocial context. They can be mediated by expectations, and may emerge in somatic symptoms even when people are aware of these effects. Interindividual differences (e.g., in personality, affective states) could impact placebo and nocebo responding, but findings are inconsistent. Methods: The current work examined expectation as a mediator of the association between verbal placebo an",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-152","Increasing the Effectiveness of a Physical Activity Smartphone Intervention With Positive Suggestions: Randomized Controlled Trial","Aleksandrina Skvortsova","McGill University","CA","BACKGROUND: eHealth interventions have the potential to increase the physical activity of users. However, their effectiveness varies, and they often have only short-term effects. A possible way of enhancing their effectiveness is to increase the positive outcome expectations of users by giving them positive suggestions regarding the effectiveness of the intervention. It has been shown that when individuals have positive expectations regarding various types of interventions, they tend to benefit ",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-453-14-005-","Statistical testing in transcriptomic‐neuroimaging studies: A how‐to and evaluation of methods assessing spatial and gene specificity","Martijn P. van den Heuvel","Amsterdam Neuroscience","Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely used approach for exploring the molecular underpinnings of large-scale brain organization in health and disease. Proper statistical evaluation of determined associations between imaging-based phenotypic and transcriptomic data is key in these explorations, in particular to establish whether observed associations exceed \"chance level\" of random, nonspecific effects. Recent approaches have shown the importance",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":20,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-2018-2019-sylvestre-bonnet-","Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy","Sylvestre Bonnet","Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]1.5(bis)](PF6)3 (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex 1) and bis bridging ligands. The as-synthesized CPNs (50 ± 12 nm diameter) showed high colloidal and chemical stability in physiological solutions. The axial bis(imidazole) ligands coordin",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":12,"year":13,"amount":14,"abstract":45},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-090","Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in \u003Ci>Aedes aegypti\u003C\u002Fi> mosquitoes","Ronald P. van Rij","Radboud University Nijmegen","Abstract In the germline of animals, PIWI interacting (pi)RNAs protect the genome against the detrimental effects of transposon mobilization. In Drosophila, piRNA-mediated cleavage of transposon RNA triggers the production of responder piRNAs via ping-pong amplification. Responder piRNA 3′ end formation by the nuclease Zucchini is coupled to the production of downstream trailer piRNAs, expanding the repertoire of transposon piRNA sequences. In Aedes aegypti mosquitoes, piRNAs are generated from ",{"id":47,"funder":7,"programme":8,"title":48,"piName":49,"institution":50,"country":12,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-277-20-008-2737","Mobilizing the Sense of “Fat”: A Phenomenological Materialist Approach","Jenny Slatman","Tilburg University","Abstract This paper aims to mobilize the way we think and write about fat bodies while drawing on Jean-Luc Nancy’s philosophy of the body. I introduce Nancy’s approach to the body as an addition to contemporary new materialism. His philosophy, so I argue, offers a form of materialism that allows for a phenomenological exploration of the body. As such, it can help us to understand the lived experiences of fat embodiment. Additionally, Nancy’s idea of the body in terms of a “corpus”—a collection o",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":44,"country":12,"year":13,"amount":14,"abstract":56},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vici-grant-016-176-622","Nanoengineering Apolipoprotein A1‐Based Immunotherapeutics","Willem J. M. Mulder","Abstract In the slipstream of targeting the adaptive immune system, innate immunotherapy strategies are being developed. In this context, technologies based on natural carrier vehicles that inherently interact with the innate immune system, are increasingly being considered. Immunoregulatory nanotherapeutics based on natural apolipoprotein A1 (apoA1) are discussed here. This protein is a helical, amphipathic macromolecule and the main constituent of high‐density lipoprotein. In that capacity, ap",{"id":58,"funder":7,"programme":8,"title":59,"piName":60,"institution":61,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-918-15-608","Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain","Niels Eijkelkamp","Utrecht University",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":44,"country":12,"year":13,"amount":14,"abstract":66},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-918-14-655-","A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery","Johannes Textor","BACKGROUND: Predicting treatment response or survival of cancer patients remains challenging in immuno-oncology. Efforts to overcome these challenges focus, among others, on the discovery of new biomarkers. Despite advances in cellular and molecular approaches, only a limited number of candidate biomarkers eventually enter clinical practice. METHODS: A computational modeling approach based on ordinary differential equations was used to simulate the fundamental mechanisms that dictate tumor-immun",{"id":68,"funder":7,"programme":8,"title":69,"piName":70,"institution":44,"country":12,"year":13,"amount":14,"abstract":71},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-346-724-011-002","Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism","Rianne E. van Outersterp","The identification of disease biomarkers plays a crucial role in developing diagnostic strategies for inborn errors of metabolism and understanding their pathophysiology. A primary metabolite that accumulates in the inborn error phenylketonuria is phenylalanine, however its levels do not always directly correlate with clinical outcomes. Here we combine infrared ion spectroscopy and NMR spectroscopy to identify the Phe-glucose Amadori rearrangement product as a biomarker for phenylketonuria. Addi",{"id":73,"funder":7,"programme":8,"title":69,"piName":70,"institution":44,"country":12,"year":13,"amount":14,"abstract":71},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-346",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":12,"year":13,"amount":14,"abstract":79},"openalex-nederlandse-organisatie-voor-wetenschapp-award-i-grant-016-vici-170-200","Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation","Koen Bolhuis","Erasmus MC","Previous studies have shown that schizophrenia polygenic risk predicts a multitude of mental health problems in the general population. Yet it is unclear by which mechanisms these associations arise. Here, we explored a possible gene-environment correlation in the association of schizophrenia polygenic risk with mental health problems via childhood adversity. This study was embedded in the population-based Generation R Study, including N = 1901 participants with genotyping for schizophrenia poly",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":84,"country":12,"year":13,"amount":14,"abstract":85},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-grant-865-17-003","Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex","Nora Jamann","Netherlands Institute for Neuroscience","The axon initial segment (AIS) is a critical microdomain for action potential initiation and implicated in the regulation of neuronal excitability during activity-dependent plasticity. While structural AIS plasticity has been suggested to fine-tune neuronal activity when network states change, whether it acts in vivo as a homeostatic regulatory mechanism in behaviorally relevant contexts remains poorly understood. Using the mouse whisker-to-barrel pathway as a model system in combination with im",{"id":87,"funder":7,"programme":8,"title":88,"piName":89,"institution":90,"country":12,"year":13,"amount":14,"abstract":91},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-016-vici-170-111","Effect of Channel Interaction on Vocal Cue Perception in Cochlear Implant Users","Nawal El Boghdady","University Medical Center Groningen","Speech intelligibility in multitalker settings is challenging for most cochlear implant (CI) users. One possibility for this limitation is the suboptimal representation of vocal cues in implant processing, such as the fundamental frequency (F0), and the vocal tract length (VTL). Previous studies suggested that while F0 perception depends on spectrotemporal cues, VTL perception relies largely on spectral cues. To investigate how spectral smearing in CIs affects vocal cue perception in speech-on-s",{"id":93,"funder":7,"programme":8,"title":94,"piName":95,"institution":50,"country":12,"year":13,"amount":14,"abstract":96},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-277-20-008","“It’s not all nice and fun”: Narrating contested illness on YouTube and Instagram","Irene Groenevelt","This empirical study draws on insights from narrative theory to tease out how women with a contested illness narrate their experiences on social media. Based on 13 months of online observations between 2017 and 2019, I analyse how a sample of eight highly active Dutch female social media users share their illness on YouTube and Instagram. In addition, I interviewed five of them. Through their online performances, the women in this study illustrate their investment in self-care practices, whilst ",16,{"programme":8,"total":99,"withPiName":99,"firstYear":100,"lastYear":101,"countryCount":102,"perYear":103,"topInstitutions":148,"topCountries":198},296,2008,2026,18,[104,106,108,110,113,116,119,122,125,128,131,133,134,137,140,143,146],{"year":100,"count":105},1,{"year":107,"count":105},2011,{"year":109,"count":105},2012,{"year":111,"count":112},2013,3,{"year":114,"count":115},2014,4,{"year":117,"count":118},2015,7,{"year":120,"count":121},2016,14,{"year":123,"count":124},2017,44,{"year":126,"count":127},2018,65,{"year":129,"count":130},2019,9,{"year":132,"count":102},2020,{"year":13,"count":97},{"year":135,"count":136},2022,22,{"year":138,"count":139},2023,27,{"year":141,"count":142},2024,26,{"year":144,"count":145},2025,23,{"year":101,"count":147},15,[149,151,153,154,156,159,161,163,165,167,168,170,172,174,176,178,180,182,184,186,189,191,193,195,197],{"name":61,"count":150},40,{"name":44,"count":152},24,{"name":20,"count":136},{"name":155,"count":136},"University of Amsterdam",{"name":157,"count":158},"Vrije Universiteit Amsterdam",20,{"name":160,"count":147},"Eindhoven University of Technology",{"name":90,"count":162},13,{"name":164,"count":118},"University of Groningen",{"name":33,"count":166},6,{"name":78,"count":166},{"name":169,"count":166},"University Medical Center Utrecht",{"name":84,"count":171},5,{"name":173,"count":171},"University of Twente",{"name":175,"count":115},"Delft University of Technology",{"name":177,"count":115},"Institute for Atomic and Molecular Physics",{"name":179,"count":115},"Leiden University Medical Center",{"name":181,"count":115},"Wageningen University & Research",{"name":183,"count":112},"Broad Institute",{"name":185,"count":112},"The Netherlands Cancer Institute",{"name":187,"count":188},"Academic Medical Center",2,{"name":190,"count":188},"Amsterdam UMC Location University of Amsterdam",{"name":192,"count":188},"Maastricht University",{"name":194,"count":188},"Oncode Institute",{"name":196,"count":188},"Radboud University Medical Center",{"name":50,"count":188},[199,201,204,206,208,210,212,213,215,217,219,221,223,225,227,229,231,233],{"name":12,"count":200},234,{"name":202,"count":203},"US",17,{"name":205,"count":171},"DE",{"name":207,"count":115},"GB",{"name":209,"count":112},"CH",{"name":211,"count":112},"IT",{"name":27,"count":188},{"name":214,"count":188},"ZA",{"name":216,"count":105},"AT",{"name":218,"count":105},"AU",{"name":220,"count":105},"BE",{"name":222,"count":105},"BR",{"name":224,"count":105},"CN",{"name":226,"count":105},"CZ",{"name":228,"count":105},"IE",{"name":230,"count":105},"QA",{"name":232,"count":105},"RU",{"name":234,"count":105},"TH"]