[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2022":3,"awarded-stats-nwo-vici":126},{"awarded":4,"total":125},[5,16,22,28,33,38,44,51,56,61,66,73,79,84,89,94,96,100,105,107,113,120],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-406-20-go-032","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Towards a dynamic account of chronic pain","Madelon L. Peters","Maastricht University","NL",2022,null,"sponsorship: J.W.S. Vlaeyen is supported by the research program \"From Acute Aversive Sensations to Chronic Bodily Symptoms,\" a long-term structural Methusalem funding (METH\u002F15\u002F011) by the Flemish government, Belgium, and J.W.S. Vlaeyen and M.L. Peters are supported by the NWO gravitation program \"New Science of Mental Disorders\": www.nsmd.eu (grant number 024.004.016) by the Dutch Research Council and the Dutch Ministry of Education, Culture and Science. J.M.B. Haslbeck is supported by NWO Vici",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-scheme-016-160-324","Using modelled relationships and satellite observations to attribute modelled aerosol biases over biomass burning regions","Qirui Zhong","Vrije Universiteit Amsterdam","Biomass burning (BB) is a major source of aerosols that remain the most uncertain components of the global radiative forcing. Current global models have great difficulty matching observed aerosol optical depth (AOD) over BB regions. A common solution to address modelled AOD biases is scaling BB emissions. Using the relationship from an ensemble of aerosol models and satellite observations, we show that the bias in aerosol modelling results primarily from incorrect lifetimes and underestimated ma",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-68047618","Mode Mapping Photonic Crystal Nanocavities with \u003Cmml:math xmlns:mml=\"http:\u002F\u002Fwww.w3.org\u002F1998\u002FMath\u002FMathML\" display=\"inline\" overflow=\"scroll\">\u003Cmml:mi>Q\u003C\u002Fmml:mi>\u003Cmml:mo>>\u003C\u002Fmml:mo>\u003Cmml:mn>5\u003C\u002Fmml:mn>\u003Cmml:mo>×\u003C\u002Fmml:mo>\u003Cmml:msup>\u003Cmml:mn>10\u003C\u002Fmml:mn>\u003Cmml:mn>5\u003C\u002Fmml:mn>\u003C\u002Fmml:msup>\u003C\u002Fmml:math> Using Free-Carrier Absorption","Karindra Perrier","Utrecht University","We demonstrate a nonlinear photomodulation spectroscopy method to image the mode profile of a high-$Q$ photonic crystal resonator (PhCR). This far-field imaging method is suitable for ultrahigh-$Q$ cavities which we demonstrate on a $Q=619\\phantom{\\rule{0.1em}{0ex}}000$ PhCR. We scan the PhCR surface with a 405-nm pump beam that modulates the refractive index by local thermal tuning, while probing the response of the resonance. We enhance resolution by probing at high power, using the thermo-opt",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-453-12-0010","Trauma-induced human glucocorticoid receptor expression increases predict subsequent HPA-axis blunting in a prospective longitudinal design","Lycia D. de Voogd","Radboud University Nijmegen",{"id":34,"funder":7,"programme":8,"title":35,"piName":36,"institution":26,"country":12,"year":13,"amount":14,"abstract":37},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-16-130-344","Particle Size Effects in the Selective Hydrogenation of Alkadienes over Supported Cu Nanoparticles","Petra E. de Jongh","Abstract Copper is considered an excellent alternative to noble‐metal selective hydrogenation catalysts. Herein, we systematically studied the effect of Cu nanoparticle size (2–10 nm) in the selective hydrogenation of 1,3‐butadiene in excess of propene. The catalysts exhibited particle size‐dependent activity, with particles above 4 nm being 3 to 4 times more active than the 2 nm ones, and at the same time more selective (up to 99 % at almost full butadiene conversion for 7–10 nm particles). The",{"id":39,"funder":7,"programme":8,"title":40,"piName":41,"institution":42,"country":12,"year":13,"amount":14,"abstract":43},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-grant-865-14-006","Plant-litter-soil feedbacks in common grass species are slightly negative and only marginally modified by litter exposed to insect herbivory","Jonathan R. De Long","Netherlands Institute of Ecology","Abstract Purpose Insect herbivory affects plant growth, nutrient and secondary metabolite concentrations and litter quality. Changes to litter quality due to insect herbivory can alter decomposition, with knock on effects for plant growth mediated through the plant-litter-soil feedback pathway. Methods Using a multi-phase glasshouse experiment, we tested how changes in shoot and root litter quality of fast- and slow-growing grass caused by insect herbivores affect the performance of response pla",{"id":45,"funder":7,"programme":8,"title":46,"piName":47,"institution":48,"country":49,"year":13,"amount":14,"abstract":50},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-project-91814643","Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer","Leonie Ratz","University Hospital Cologne","DE","BACKGROUND: The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the need for the development of novel targeted therapies for this tumor subtype. METHODS: Our group previously showed that EZH2 is functionally relevant in BRCA1-deficient breast tumors and blocking EZH2 enzymatic activity could be a potent treatment strategy. ",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":20,"country":12,"year":13,"amount":14,"abstract":55},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-724-017-001","Relativistic reduced density matrix functional theory","Mauricio Rodríguez‐Mayorga","As a new approach to efficiently describe correlation effects in the relativistic quantum world we propose to consider reduced density matrix functional theory, where the key quantity is the first-order reduced density matrix (1-RDM). In this work, we first introduce the theoretical foundations to extend the applicability of this theory to the relativistic domain. Then, using the so-called no-pair (np) approximation, we arrive at an approximate treatment of the relativistic effects by focusing o",{"id":57,"funder":7,"programme":8,"title":58,"piName":59,"institution":32,"country":12,"year":13,"amount":14,"abstract":60},"openalex-nederlandse-organisatie-voor-wetenschapp-award-16-vici-170-090","SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients","Marien I. de Jonge","Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air has not yet been sufficiently demonstrated. In pandemic situations low tech disposable and user-friendly bedside devices are required, while commercially available samplers are unsuitable for applicati",{"id":62,"funder":7,"programme":8,"title":63,"piName":64,"institution":26,"country":12,"year":13,"amount":14,"abstract":65},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-160-638","The spread of the first introns in proto-eukaryotic paralogs","Julian Vosseberg","Spliceosomal introns are a unique feature of eukaryotic genes. Previous studies have established that many introns were present in the protein-coding genes of the last eukaryotic common ancestor (LECA). Intron positions shared between genes that duplicated before LECA could in principle provide insight into the emergence of the first introns. In this study we use ancestral intron position reconstructions in two large sets of duplicated families to systematically identify these ancient paralogous",{"id":67,"funder":7,"programme":8,"title":68,"piName":69,"institution":70,"country":71,"year":13,"amount":14,"abstract":72},"openalex-nederlandse-organisatie-voor-wetenschapp-award-435-14-005","Correction: Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments","Josefin Werme","Cognitive Research (United States)","US","The original version of this article contained a mistake in the Acknowledgements. The following sentence should be changed from “This work was funded by COSYN (Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders: Horizon 2020 Program of the European Union under RIA grant agreement 667301 to D.P.) and the Netherlands Organization for Scientific Research (NWO: VICI 435-14-005).” to “This work was funded by COSYN (Comorbidity and Synapse Biology in Clinically Overlapping",{"id":74,"funder":7,"programme":8,"title":75,"piName":76,"institution":77,"country":12,"year":13,"amount":14,"abstract":78},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-918-16-616","\u003Cscp>CADASIL\u003C\u002Fscp> Affects Multiple Aspects of Cerebral Small Vessel Function on \u003Cscp>7T‐MRI\u003C\u002Fscp>","Geert Jan Biessels","University Medical Center Utrecht","OBJECTIVE: Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting-edge 7T-MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), to establish which aspects of cerebral small vessel function are affected by this monogenic form of cSVD. METHODS: We recruited 23 CADASIL patients (age 51.1 ± 10.1 years, 52% women) and 13 age- and sex-matched controls (46.1 ± 12.6, 46% women). Smal",{"id":80,"funder":7,"programme":8,"title":81,"piName":82,"institution":32,"country":12,"year":13,"amount":14,"abstract":83},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-195-197-016-vici-185-038-057-14-003","Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior","Carolina de Weerth","Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond documented positive effects of breastfeeding on infant and maternal health, there is increasing evidence that milk constituents also impact child neurodevelopment. Non-nutrient milk bioactives would contribute to the (long-term) development of child cognition and behavior, a process termed 'Lactocrine Programming'. In this review we discuss the current state of the field on human milk composition and its li",{"id":85,"funder":7,"programme":8,"title":86,"piName":87,"institution":20,"country":12,"year":13,"amount":14,"abstract":88},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-865-12-003","Lack of lipid accumulation in two species of chalcidoid wasps with secondarily evolved phytophagy","Jacintha Ellers","Abstract Stable co‐evolutionary relationships between species may result in the loss of autonomous synthesis of essential nutrients when these can be obtained from the ecological partner. Parasitoid insects obtain most of their nutrients from their host, and many lineages do not increase their adult lipid reserves even when feeding on a surplus of sugars. Several clades within the parasitoid Hymenoptera have lost the parasitoid lifestyle and switched to either a predatory or a phytophagous lifes",{"id":90,"funder":7,"programme":8,"title":91,"piName":92,"institution":26,"country":12,"year":13,"amount":14,"abstract":93},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-vici-170-165","Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans","Mike Boxem","Crumbs proteins are evolutionarily conserved transmembrane proteins with essential roles in promoting the formation of the apical domain in epithelial cells. The short intracellular tail of Crumbs proteins are known to interact with several proteins, including the scaffolding protein PALS1 (protein associated with LIN7, Stardust in Drosophila). PALS1 in turn binds to a second scaffolding protein PATJ (PALS1-associated tight junction protein) to form the core Crumbs\u002FPALS1\u002FPATJ complex. While esse",{"id":95,"funder":7,"programme":8,"title":91,"piName":92,"institution":26,"country":12,"year":13,"amount":14,"abstract":93},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-016-vici-170-165",{"id":97,"funder":7,"programme":8,"title":98,"piName":99,"institution":26,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-865-17-001-","Plate tectonic chain reaction revealed by noise in the Cretaceous quiet zone","Derya Gürer",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":26,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-865-14-004","Molecular Signatures and Cellular Diversity During Mouse Habenula Development","R. Jeroen Pasterkamp","SUMMARY The habenula plays a key role in various motivated and pathological behaviors and is composed of molecularly distinct neuron subtypes. Despite progress in identifying mature habenula neuron subtypes, how these subtypes develop and organize into functional brain circuits remains largely unknown. Here we performed single-cell transcriptional profiling of mouse habenular neurons at critical developmental stages instructed by detailed three-dimensional anatomical data. Our data reveal cellul",{"id":106,"funder":7,"programme":8,"title":102,"piName":103,"institution":26,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vici-865-14-004",{"id":108,"funder":7,"programme":8,"title":109,"piName":110,"institution":111,"country":12,"year":13,"amount":14,"abstract":112},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-016-vici-170-200","Sleep and mental health in childhood: a multi-method study in the general pediatric population","Elisabet Blok","Erasmus MC","BACKGROUND: Sleep problems, altered sleep patterns and mental health difficulties often co-occur in the pediatric population. Different assessment methods for sleep exist, however, many studies only use one measure of sleep or focus on one specific mental health problem. In this population-based study, we assessed different aspects of sleep and mother-reported mental health to provide a broad overview of the associations between reported and actigraphic sleep characteristics and mental health. M",{"id":114,"funder":7,"programme":8,"title":115,"piName":116,"institution":117,"country":118,"year":13,"amount":14,"abstract":119},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-639-023-812","Sticky Brownian Rounding and its Applications to Constraint Satisfaction Problems","Sepehr Abbasi-Zadeh","University of Toronto","CA","Semidefinite programming is a powerful tool in the design and analysis of approximation algorithms for combinatorial optimization problems. In particular, the random hyperplane rounding method of Goemans and Williamson [ 31 ] has been extensively studied for more than two decades, resulting in various extensions to the original technique and beautiful algorithms for a wide range of applications. Despite the fact that this approach yields tight approximation guarantees for some problems, e.g., Ma",{"id":121,"funder":7,"programme":8,"title":122,"piName":123,"institution":26,"country":12,"year":13,"amount":14,"abstract":124},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-016-130-663","Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior","Milou Straathof","RATIONALE: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. OBJECTIVE: Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compulsivity. METHODS: Juvenile Sprague-Dawley rats received repeated quin",22,{"programme":8,"total":127,"withPiName":127,"firstYear":128,"lastYear":129,"countryCount":130,"perYear":131,"topInstitutions":176,"topCountries":228},296,2008,2026,18,[132,134,136,138,141,144,147,150,153,156,159,161,164,165,168,171,174],{"year":128,"count":133},1,{"year":135,"count":133},2011,{"year":137,"count":133},2012,{"year":139,"count":140},2013,3,{"year":142,"count":143},2014,4,{"year":145,"count":146},2015,7,{"year":148,"count":149},2016,14,{"year":151,"count":152},2017,44,{"year":154,"count":155},2018,65,{"year":157,"count":158},2019,9,{"year":160,"count":130},2020,{"year":162,"count":163},2021,16,{"year":13,"count":125},{"year":166,"count":167},2023,27,{"year":169,"count":170},2024,26,{"year":172,"count":173},2025,23,{"year":129,"count":175},15,[177,179,181,183,185,187,189,192,194,197,198,199,202,204,206,208,210,212,214,216,219,221,222,224,226],{"name":26,"count":178},40,{"name":32,"count":180},24,{"name":182,"count":125},"Leiden University",{"name":184,"count":125},"University of Amsterdam",{"name":20,"count":186},20,{"name":188,"count":175},"Eindhoven University of Technology",{"name":190,"count":191},"University Medical Center Groningen",13,{"name":193,"count":146},"University of Groningen",{"name":195,"count":196},"Amsterdam Neuroscience",6,{"name":111,"count":196},{"name":77,"count":196},{"name":200,"count":201},"Netherlands Institute for Neuroscience",5,{"name":203,"count":201},"University of Twente",{"name":205,"count":143},"Delft University of Technology",{"name":207,"count":143},"Institute for Atomic and Molecular Physics",{"name":209,"count":143},"Leiden University Medical Center",{"name":211,"count":143},"Wageningen University & Research",{"name":213,"count":140},"Broad Institute",{"name":215,"count":140},"The Netherlands Cancer Institute",{"name":217,"count":218},"Academic Medical Center",2,{"name":220,"count":218},"Amsterdam UMC Location University of Amsterdam",{"name":11,"count":218},{"name":223,"count":218},"Oncode Institute",{"name":225,"count":218},"Radboud University Medical Center",{"name":227,"count":218},"Tilburg University",[229,231,233,234,236,238,240,241,243,245,247,249,251,253,255,257,259,261],{"name":12,"count":230},234,{"name":71,"count":232},17,{"name":49,"count":201},{"name":235,"count":143},"GB",{"name":237,"count":140},"CH",{"name":239,"count":140},"IT",{"name":118,"count":218},{"name":242,"count":218},"ZA",{"name":244,"count":133},"AT",{"name":246,"count":133},"AU",{"name":248,"count":133},"BE",{"name":250,"count":133},"BR",{"name":252,"count":133},"CN",{"name":254,"count":133},"CZ",{"name":256,"count":133},"IE",{"name":258,"count":133},"QA",{"name":260,"count":133},"RU",{"name":262,"count":133},"TH"]