[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2024":3,"awarded-stats-nwo-vici":153},{"awarded":4,"total":152},[5,16,21,28,34,40,43,47,53,58,63,69,74,80,87,93,98,104,110,116,122,128,133,135,141,146],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-vi-c-202-022","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation","Joanne A. Hoogerland","University Medical Center Groningen","NL",2024,null,"BACKGROUND: The plasma metabolome reflects the physiological state of various biological processes and can serve as a proxy for disease risk. Plasma metabolite variation, influenced by genetic and epigenetic mechanisms, can also affect the cellular microenvironment and blood cell epigenetics. The interplay between the plasma metabolome and the blood cell epigenome remains elusive. In this study, we performed an epigenome-wide association study (EWAS) of 1183 plasma metabolites in 693 participant",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-nwo-vici-grant-09150181910040-","Author response to ‘Clarification on the incidence and sex-specificity of sexual dysfunction as an adverse event of CGRP-targeting medications’","Antoinette MaassenVanDenBrink","Erasmus MC",{"id":22,"funder":7,"programme":8,"title":23,"piName":24,"institution":25,"country":26,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-185-068","Large orders in small markets: execution with endogenous liquidity supply","Agostino Capponi","Columbia University","US","Abstract We model the execution of a large uninformed sell order in the presence of strategic competitive market makers. We solve for the unique symmetric equilibrium of the model in closed form. Analysis of this equilibrium reveals that large orders unequivocally benefit market makers, while smaller investors stand to benefit only if the order trades with a sufficiently high intensity. The equilibrium results further provide a rationale for the empirically observed patterns of (1) shorter order",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":12,"year":13,"amount":14,"abstract":33},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-680-47-628","Polaritonic Chemistry Enabled by Non‐Local Metasurfaces","Jaime Gómez Rivas","Eindhoven University of Technology","Vibrational strong coupling can modify chemical reaction pathways in unconventional ways. Thus far, Fabry-Perot cavities formed by pairs of facing mirrors have been mostly utilized to achieve vibrational strong coupling. In this study, we demonstrate the application of non-local metasurfaces that can sustain surface lattice resonances, enabling chemical reactions under vibrational strong coupling. We show that the solvolysis kinetics of para-nitrophenyl acetate can be accelerated by a factor of ",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-91818627-","Primary SARS-CoV-2 variant of concern infections elicit broad antibody Fc-mediated effector functions and memory B cell responses","Karlijn van der Straten","Amsterdam UMC Location University of Amsterdam","Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by human sera is a strong correlate of protection against symptomatic and severe Coronavirus Disease 2019 (COVID-19). The emergence of antigenically distinct SARS-CoV-2 variants of concern (VOCs) and the relatively rapid waning of serum antibody titers, however, raises questions about the sustainability of serum protection. In addition to serum neutralization, other antibody functionalities and the memory B cell (MBC)",{"id":41,"funder":7,"programme":8,"title":9,"piName":42,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vici-09150182010019","Jiafei Wu",{"id":44,"funder":7,"programme":8,"title":45,"piName":46,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-2019-2020","Estimating option pricing models using a characteristic function-based linear state space representation","H. Peter Boswijk",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":51,"country":12,"year":13,"amount":14,"abstract":52},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-181-029","Subjective evidence evaluation survey for many-analysts studies","Alexandra Sarafoglou","University of Amsterdam","Many-analysts studies explore how well an empirical claim withstands plausible alternative analyses of the same dataset by multiple, independent analysis teams. Conclusions from these studies typically rely on a single outcome metric (e.g. effect size) provided by each analysis team. Although informative about the range of plausible effects in a dataset, a single effect size from each team does not provide a complete, nuanced understanding of how analysis choices are related to the outcome. We u",{"id":54,"funder":7,"programme":8,"title":55,"piName":56,"institution":51,"country":12,"year":13,"amount":14,"abstract":57},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-185-077","‘The right to fall in love and kiss without consequences’: on racialized Muslim women, ‘mixed’ intimacies, and Dutch sexual exceptionalism","Sherilyn Deen","What does political concern with ‘mixed’ intimacies articulate about the nation? This article unpacks this question by analysing a Dutch poster campaign on self-determination, organized by the Rotterdam municipality and a feminist NGO, that visualized ‘mixed’ couples intimately kissing. It uses a visual analysis of the posters, combined with a post-structural policy analysis of a variety of documents that were essential to the production of this campaign. First, the article argues that the campa",{"id":59,"funder":7,"programme":8,"title":60,"piName":61,"institution":62,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-170-190","Worldwide greenhouse gas emissions of green hydrogen production and transport","Kiane de Kleijne","Radboud University Nijmegen",{"id":64,"funder":7,"programme":8,"title":65,"piName":66,"institution":67,"country":26,"year":13,"amount":14,"abstract":68},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-17846","Structural Aspects of MoS\u003Csub>\u003Ci>x\u003C\u002Fi>\u003C\u002Fsub> Prepared by Atomic Layer Deposition for Hydrogen Evolution Reaction","Ageeth A. Bol","University of Michigan","HER electrocatalysts as well as new insights into their activity and structure.",{"id":70,"funder":7,"programme":8,"title":71,"piName":72,"institution":32,"country":12,"year":13,"amount":14,"abstract":73},"openalex-nederlandse-organisatie-voor-wetenschapp-award-gravitation-grant-networks-024-002-003-vici-grant-202-068","Server Saturation in Skewed Networks","Diego Goldsztajn","We use bipartite graphs to model compatibility constraints that arise between tasks and servers in data centers, cloud computing systems and content delivery networks. We prove that servers with skewed graph neighborhoods saturate with tasks in a limiting regime. The neighborhood of a server is skewed if it contains a diverging number of dispatchers with uniformly bounded degrees.",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":12,"year":13,"amount":14,"abstract":79},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-680-47-632","Viscoelastic wetting: Cox–Voinov theory with normal stress effects","Minkush Kansal","University of Twente","The classical Cox–Voinov theory of contact line motion provides a relation between the macroscopically observable contact angle, and the microscopic wetting angle as a function of contact-line velocity. Here, we investigate how viscoelasticity, specifically the normal stress effect, modifies the wetting dynamics. Using the thin film equation for the second-order fluid, it is found that the normal stress effect is dominant at small scales yet can significantly affect macroscopic motion. We show t",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":84,"country":85,"year":13,"amount":14,"abstract":86},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-016-vici-185-050-","V1 neurons are tuned to perceptual borders in natural scenes","Paolo Papale","IMT School for Advanced Studies Lucca","IT","The visual system needs to identify perceptually relevant borders to segment complex natural scenes. The primary visual cortex (V1) is thought to extract local borders, and higher visual areas are thought to identify the perceptually relevant borders between objects and the background. To test this conjecture, we used natural images that had been annotated by human observers who marked the perceptually relevant borders. We assessed the effect of perceptual relevance on V1 responses using human n",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":12,"year":13,"amount":14,"abstract":92},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-680-47-633","Kinetic control over the chiral-selectivity in the formation of organometallic polymers on a Ag(110) surface","R. S. Koen Houtsma","University of Groningen","Methods to control chiral-selectivity in molecular reactions through external inputs are of importance, both from a fundamental and technological point of view. Here, the self-assembly of prochiral 6,12-dibromochrysene monomers on Ag(110) is studied using scanning tunneling microscopy. Deposition of the monomers on a substrate held at room temperature leads to the formation of 1D achiral organometallic polymers. When the monomers are instead deposited on a substrate held at 373 K, homochiral org",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":11,"country":12,"year":13,"amount":14,"abstract":97},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-453-16-007-2735","Once in NEET, always in NEET? Childhood and adolescent risk factors for different NEET patterns","Karin Veldman","BACKGROUND: Young adults in Neither in Employment, Education nor Training (NEET) are at risk of adverse labour market outcomes. Earlier studies often measured NEET status at one time point or compared persistent NEETs with non-NEETs, neglecting other patterns of NEET status. Evidence on early life factors associated with NEET patterns is lacking. This study aims to (i) identify patterns of NEET status over time and (ii) examine whether factors in childhood and adolescence are associated with the",{"id":99,"funder":7,"programme":8,"title":100,"piName":101,"institution":102,"country":26,"year":13,"amount":14,"abstract":103},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-918-17-603","Lexical effects on talker discrimination in adult cochlear implant users","Terrin N. Tamati","Vanderbilt University Medical Center","The lexical and phonological content of an utterance impacts the processing of talker-specific details in normal-hearing (NH) listeners. Adult cochlear implant (CI) users demonstrate difficulties in talker discrimination, particularly for same-gender talker pairs, which may alter the reliance on lexical information in talker discrimination. The current study examined the effect of lexical content on talker discrimination in 24 adult CI users. In a remote AX talker discrimination task, word pairs",{"id":105,"funder":7,"programme":8,"title":106,"piName":107,"institution":108,"country":12,"year":13,"amount":14,"abstract":109},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-724-014-001","Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection","Roy Pattipeiluhu","Leiden University","Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the recent implementation of several vaccines against SARS-CoV-2. Using a bottom-up rational design approach, we assemble LNPs that contain programmable lipid phases encapsulating small interfering RNA (siRNA). A combination of cryogenic transmission electron micro",{"id":111,"funder":7,"programme":8,"title":112,"piName":113,"institution":114,"country":12,"year":13,"amount":14,"abstract":115},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-016-160-638","Intracellular signaling in proto-eukaryotes evolves to alleviate regulatory conflicts of endosymbiosis","Samuel H. A. von der Dunk","Utrecht University","The complex eukaryotic cell resulted from a merger between simpler prokaryotic cells, yet the role of the mitochondrial endosymbiosis with respect to other eukaryotic innovations has remained under dispute. To investigate how the regulatory challenges associated with the endosymbiotic state impacted genome and network evolution during eukaryogenesis, we study a constructive computational model where two simple cells are forced into an obligate endosymbiosis. Across multiple in silico evolutionar",{"id":117,"funder":7,"programme":8,"title":118,"piName":119,"institution":120,"country":12,"year":13,"amount":14,"abstract":121},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-2018-91819642","Characterization of the human fetal gonad and reproductive tract by single-cell transcriptomics","Xueying Fan","Leiden University Medical Center","During human fetal development, sex differentiation occurs not only in the gonads but also in the adjacent developing reproductive tract. However, while the cellular composition of male and female human fetal gonads is well described, that of the adjacent developing reproductive tract remains poorly characterized. Here, we performed single-cell transcriptomics on male and female human fetal gonads together with the adjacent developing reproductive tract from first and second trimesters, highligh",{"id":123,"funder":7,"programme":8,"title":124,"piName":125,"institution":126,"country":12,"year":13,"amount":14,"abstract":127},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-no-16122-","Optimizing ionic transport in argyrodites: a unified view on the role of sulfur\u002Fhalide distribution and local environments","Marnix Wagemaker","Delft University of Technology","molecular dynamics, focusing on the correlation between key structural descriptors and Li-ion conductivity. Commonly suggested parameters, such as configurational entropy, bromide site occupancy, and bromine content, correlate with Li-ion diffusivity but do not consistently explain conductivity trends. We find that a uniform distribution of bromine and sulfur ions across the 4a and 4d sublattices is critical for achieving high conductivity by facilitating optimal lithium jump activation energies",{"id":129,"funder":7,"programme":8,"title":130,"piName":131,"institution":108,"country":12,"year":13,"amount":14,"abstract":132},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-91819616","Single-cell analysis of innate immune cell mechanics: an application to cancer immunology","Tom M. J. Evers","Alterations in the tumor microenvironment not only modulate cancer cell progression and invasiveness but also affect the viscoelastic properties of immune cells therein.",{"id":134,"funder":7,"programme":8,"title":130,"piName":131,"institution":108,"country":12,"year":13,"amount":14,"abstract":132},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-91819616",{"id":136,"funder":7,"programme":8,"title":137,"piName":138,"institution":139,"country":12,"year":13,"amount":14,"abstract":140},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-185-084","Conditions for Transformative Engaged Scholarship in Co-creation with Queer Refugees","Fabian Holle","Vrije Universiteit Amsterdam","Abstract This chapter focuses on conditions for co-creative research with regard to experiences and diverse forms of knowledge that are silenced by stigmatizing, negative labelling and (subtle) kinds of exclusion. We reflect on three core conditions that emerged in LIMBO, a creative research collaboration between queer refugee community organizers and artists, the Amsterdam art institute Framer Framed and the Refugee Academy (expertise lab based at the Institute for Societal Resilience at VU Ams",{"id":142,"funder":7,"programme":8,"title":143,"piName":144,"institution":32,"country":12,"year":13,"amount":14,"abstract":145},"openalex-nederlandse-organisatie-voor-wetenschapp-award-680-47-628-scope-vici-","Refractive index sensing using quasi-bound states in the continuum in silicon metasurfaces","Minpeng Liang","This work presents a bulk refractive index sensor based on quasi-bound states in the continuum (BICs) induced by broken symmetries in metasurfaces. The symmetry is broken by detuning the size and position of silicon particles periodically arranged in an array, resulting in multiple quasi-BIC resonances. We investigate the sensing characteristics of each of the resonances by measuring the spectral shift in response to changes in the refractive index of the surrounding medium. In addition, we reve",{"id":147,"funder":7,"programme":8,"title":148,"piName":149,"institution":150,"country":26,"year":13,"amount":14,"abstract":151},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-16131","MALDI versus DESI mass spectrometry imaging of lipids in atherosclerotic plaque","Gijs van Soest","Harvard University","Mass spectrometry imaging (MSI) is a powerful tool for detecting lipids in tissue sections, with matrix-assisted laser desorption\u002Fionization (MALDI) and desorption electrospray ionization (DESI) as its key ionization techniques. In this study, we examine how MALDI compares with state-of-the-art DESI ionization in identifying lipids in heterogeneous samples, specifically atherosclerotic plaques. Carotid plaques (n = 4) from patients undergoing endarterectomy were snap-frozen, stored at -80°C, and",26,{"programme":8,"total":154,"withPiName":154,"firstYear":155,"lastYear":156,"countryCount":157,"perYear":158,"topInstitutions":203,"topCountries":248},296,2008,2026,18,[159,161,163,165,168,171,174,177,180,183,186,188,191,194,197,198,201],{"year":155,"count":160},1,{"year":162,"count":160},2011,{"year":164,"count":160},2012,{"year":166,"count":167},2013,3,{"year":169,"count":170},2014,4,{"year":172,"count":173},2015,7,{"year":175,"count":176},2016,14,{"year":178,"count":179},2017,44,{"year":181,"count":182},2018,65,{"year":184,"count":185},2019,9,{"year":187,"count":157},2020,{"year":189,"count":190},2021,16,{"year":192,"count":193},2022,22,{"year":195,"count":196},2023,27,{"year":13,"count":152},{"year":199,"count":200},2025,23,{"year":156,"count":202},15,[204,206,208,209,210,212,213,215,216,219,220,222,225,226,227,229,230,232,234,236,239,240,242,244,246],{"name":114,"count":205},40,{"name":62,"count":207},24,{"name":108,"count":193},{"name":51,"count":193},{"name":139,"count":211},20,{"name":32,"count":202},{"name":11,"count":214},13,{"name":91,"count":173},{"name":217,"count":218},"Amsterdam Neuroscience",6,{"name":20,"count":218},{"name":221,"count":218},"University Medical Center Utrecht",{"name":223,"count":224},"Netherlands Institute for Neuroscience",5,{"name":78,"count":224},{"name":126,"count":170},{"name":228,"count":170},"Institute for Atomic and Molecular Physics",{"name":120,"count":170},{"name":231,"count":170},"Wageningen University & Research",{"name":233,"count":167},"Broad Institute",{"name":235,"count":167},"The Netherlands Cancer Institute",{"name":237,"count":238},"Academic Medical Center",2,{"name":38,"count":238},{"name":241,"count":238},"Maastricht University",{"name":243,"count":238},"Oncode Institute",{"name":245,"count":238},"Radboud University Medical Center",{"name":247,"count":238},"Tilburg University",[249,251,253,255,257,259,260,262,264,266,268,270,272,274,276,278,280,282],{"name":12,"count":250},234,{"name":26,"count":252},17,{"name":254,"count":224},"DE",{"name":256,"count":170},"GB",{"name":258,"count":167},"CH",{"name":85,"count":167},{"name":261,"count":238},"CA",{"name":263,"count":238},"ZA",{"name":265,"count":160},"AT",{"name":267,"count":160},"AU",{"name":269,"count":160},"BE",{"name":271,"count":160},"BR",{"name":273,"count":160},"CN",{"name":275,"count":160},"CZ",{"name":277,"count":160},"IE",{"name":279,"count":160},"QA",{"name":281,"count":160},"RU",{"name":283,"count":160},"TH"]