[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vici-2025":3,"awarded-stats-nwo-vici":132},{"awarded":4,"total":131},[5,16,22,28,33,39,44,48,54,56,62,67,71,76,83,89,94,99,105,111,118,123,129],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-09150181910016","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vici","How are estimated cellular turnover rates influenced by the dynamics of a source population?","Arpit Chandan Swain","Utrecht University","NL",2025,null,"Estimating production and loss rates of cell populations is essential but difficult. The current state-of-the-art method to estimate these rates involves mathematical modelling of deuterium labelling experiments. Current models typically assume that the labelling in the precursors of the population of interest (POI) is proportional to the deuterium enrichment in body water\u002Fglucose. This assumption is not always true and it is known that this can have a significant effect on the rates estimated f",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-18683-","Solvent and temperature effects in the photoiniferter RAFT polymerisation of PEG methacrylate","Inge S. Zuhorn","University Medical Center Groningen","Photoiniferter (PI)-RAFT polymerisation is a promising approach to synthesise a broad range of polymers due to its' \"living\" nature. We have investigated the effect of illumination, solvent and temperature on the PI-RAFT polymerisation of PEGMA.",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-192-044","Unveiling New Reactivities in Complex Mixtures: Synthesis of Tricyclic Pyridinium Derivatives","Jana Roithová","Radboud University Nijmegen","The discovery of new transformations drives the development of synthetic organic chemistry. While the main goal of synthetic chemists is to obtain the maximum yield of a desired product with minimal side product formation, meticulous characterization of the latter offers an opportunity for discovering new reaction pathways, alternative mechanisms, and new products. Herein, we present a case study on the discovery and development of a new chemical transformation using online mass spectrometry. Th",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":14,"country":14,"year":13,"amount":14,"abstract":32},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-2020-2027","Robust Optimization of Rank-Dependent Models with Uncertain Probabilities","Dick den Hertog","This paper studies distributionally robust optimization for a rich class of risk measures with ambiguity sets defined by $ϕ$-divergences. The risk measures are allowed to be non-linear in probabilities, are represented by Choquet integrals possibly induced by a probability weighting function, and encompass many well-known examples. Optimization for this class of risk measures is challenging due to their rank-dependent nature. We show that for various shapes of probability weighting functions, in",{"id":34,"funder":7,"programme":8,"title":35,"piName":36,"institution":37,"country":12,"year":13,"amount":14,"abstract":38},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-865-14-003","The Tomato \u003Cscp>PR\u003C\u002Fscp> ‐5 Proteins \u003Cscp>PR\u003C\u002Fscp> ‐5x and \u003Cscp>NP24\u003C\u002Fscp> Exert Antifungal Activity Against \u003Ci>Fusarium oxysporum\u003C\u002Fi>","Frank L. W. Takken","University of Amsterdam","ABSTRACT Vascular wilt diseases, caused by the soilborne pathogen Fusarium oxysporum (Fo), significantly impact agriculture and horticulture. Traditional management strategies are often environmentally harmful and not effective once the pathogen has entered the host. Consequently, understanding the molecular mechanisms underlying resistance to pathogenic Fo strains is crucial for developing novel control strategies. In tomato, resistance to F. oxysporum f. sp. lycopersici (Fol) can be mediated b",{"id":40,"funder":7,"programme":8,"title":41,"piName":42,"institution":14,"country":14,"year":13,"amount":14,"abstract":43},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-c-191-027","Annuities","de Boer, de","This database was produced in the context of the dissertation \"A Truth Universally Acknowledged. Dutch Investment in French Colonial Resources, 1717-1792\", as part of NWO VICI project VI.C.191.027. The database consists of 581 Dutch-based investors in French annuités viagères (life annuities or lijfrenten) in the second half of the eighteenth century. It lists metadata related to their identities and investment. A protocol is attached containing details about the archival source, the selection m",{"id":45,"funder":7,"programme":8,"title":46,"piName":47,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-918-16-610","Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography","Monica Mukherjee",{"id":49,"funder":7,"programme":8,"title":50,"piName":51,"institution":52,"country":12,"year":13,"amount":14,"abstract":53},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-enw-vici-865-17-004","A model of Notch signalling control of angiogenesis: Evidence of a role for Notch ligand heterodimerization","Daipeng Chen","Leiden University","The ubiquitous Notch receptor signalling network is essential for tissue growth and maintenance. Operationally, receptor activity is regulated by two principal, counterposed mechanisms: intercellular Notch transactivation triggered by interactions between receptors and ligands expressed in neighbouring cells; intracellular cis inhibition mediated by ligands binding to receptors expressed in the same cell. Moreover, different Notch receptor\u002Fligand combinations are known to elicit distinct molecul",{"id":55,"funder":7,"programme":8,"title":50,"piName":51,"institution":52,"country":12,"year":13,"amount":14,"abstract":53},"openalex-nederlandse-organisatie-voor-wetenschapp-award-enw-vici-865-17-004",{"id":57,"funder":7,"programme":8,"title":58,"piName":59,"institution":60,"country":12,"year":13,"amount":14,"abstract":61},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-182-052","Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response","Sophie C. van der Horst","Leiden University Medical Center","Perturbation of DNA replication, for instance by hydroxyurea-dependent dNTP exhaustion, often leads to stalling or collapse of replication forks. This triggers a replication stress response that stabilizes these forks, activates cell cycle checkpoints, and induces expression of DNA damage response genes. While several factors are known to act in this response, the full repertoire of proteins involved remains largely elusive. Here, we develop Replication-IDentifier (Repli-ID), which allows for ge",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":66,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-2020","Crossing-Preserving Geodesic Tracking on Spherical Images","Nicky J. van den Berg","Eindhoven University of Technology",{"id":68,"funder":7,"programme":8,"title":18,"piName":69,"institution":20,"country":12,"year":13,"amount":14,"abstract":70},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-18683","R.‐C. CHANG","= 1.30 even at 40 °C.",{"id":72,"funder":7,"programme":8,"title":73,"piName":74,"institution":52,"country":12,"year":13,"amount":14,"abstract":75},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-453-u201312-u20130010","Amygdala Hyperactivity in Posttraumatic Stress Disorder: Disentangling Predisposing From Consequential Factors Using a Prospective Longitudinal Design","Lycia D. de Voogd","BACKGROUND: Substantial interindividual differences exist in the vulnerability to develop posttraumatic stress disorder (PTSD) symptoms following trauma exposure. Identification of neurocognitive risk markers for PTSD symptoms could aid early assessment and identification of preventive intervention targets for PTSD, particularly in high-risk professionals. Therefore, large prospective longitudinal studies with pretrauma measurements are essential to disentangle whether previously observed neurob",{"id":77,"funder":7,"programme":8,"title":78,"piName":79,"institution":80,"country":81,"year":13,"amount":14,"abstract":82},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-19391","Suppression of Plant Resistance May Be a Common Trait Among Adapted Herbivores","Jéssica Teodoro‐Paulo","Sustainability Institute","ZA","populations sampled from tomato at three field sites were compared. To discriminate between mites that induce\u002Fsuppress defenses and to assess their degree of resistance, the magnitude of induced defenses was measured and aligned with oviposition data. The expression of effector 84 was also assessed to determine whether its magnitude of expression is a good predictor of suppression with the magnitude of suppression. Surprisingly, we observed that suppression is the dominant phenotype in mite popu",{"id":84,"funder":7,"programme":8,"title":85,"piName":86,"institution":87,"country":12,"year":13,"amount":14,"abstract":88},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-09150181910040-","Unraveling the paradox: cardiovascular risk profiling in migraine– a correspondence","Linda Al‐Hassany","Erasmus MC","We read with great interest the recent publication by Marston and colleagues in Nature Medicine, entitled \"Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering\" (issue 31, March 2025, pages 963-969). Among their compelling findings, the association between the endothelial cell-specific polygenic risk score (EC-PRS) - which consists of SNPs associated with coronary artery disease - and a reduced risk of ",{"id":90,"funder":7,"programme":8,"title":91,"piName":92,"institution":60,"country":12,"year":13,"amount":14,"abstract":93},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zon-mw-vici-170-055","Establishment of patient-derived 3D in vitro models of sarcomas: literature review and guidelines on behalf of the FORTRESS working group","Sanne Venneker","Sarcomas are a large family of rare and heterogeneous mesenchymal tumors, which respond poorly to available systemic treatments. Translation of preclinical findings into clinical applications has been slow, limiting improvements in patients' outcomes and ultimately highlighting the need for a better understanding of sarcoma biology to develop more effective, subtype-specific therapies. To this end, reliable preclinical models are crucial, but the development of 3D in vitro sarcoma models has bee",{"id":95,"funder":7,"programme":8,"title":96,"piName":97,"institution":26,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vici-231-057","Unpacking similarity effects in visual memory search: categorical, semantic, and visual contributions","Marius V. Peelen","Abstract Visual memory search involves comparing a probe item against multiple memorized items. Previous work has shown that distractor probes from a different object category than the objects in the memory set are rejected more quickly than distractor probes from the same category. Because objects belonging to the same superordinate category usually share both visual and semantic features compared with objects of different categories, it is unclear whether the category effects reported in previ",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":103,"country":12,"year":13,"amount":14,"abstract":104},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-project-imbol-project-no-17070-","Dynamics of a liquid lamella during vertical impact of a solid plate","Nayoung Kim","Max Planck University of Twente Center for Complex Fluid Dynamics","We study the dynamics of a thin liquid sheet that flows upwards along the sides of a vertically aligned, impacting plate. Upon impact of the vertical solid plate onto a liquid pool, the liquid film is ejected and subsequently continues to flow over the solid surface while the plate enters the water. With increasing impact velocity, the liquid film is observed to rise up faster and higher. We focus on the time evolution of the liquid film height and the thickness of its upper rim and discuss thei",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":109,"country":12,"year":13,"amount":14,"abstract":110},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-vi-c-192-024-and-aspasia-015-015-009-","Tiny Droplets, Large Insights: Studying Peptide Aggregation with Droplet-based Microfluidics Hyphenated with Ion Mobility Mass Spectrometry","Ariadni Geballa-Koukoula","Vrije Universiteit Amsterdam","Peptide and protein aggregation is a hallmark of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and the complexity of coinciding and transient reaction networks. Confining reactions to microenvironments, such as picoliter droplets in droplet-based microfluidics (DBMF), simplifies these networks and thereby enabling high-throughput analysis and controlled reaction kinetic",{"id":112,"funder":7,"programme":8,"title":113,"piName":114,"institution":115,"country":116,"year":13,"amount":14,"abstract":117},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-09150182410051","Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives","Ignacio Fernando Hall","The Queen's Medical Research Institute","GB","Endothelial to mesenchymal transition (EndMT) is a process whereby endothelial cells transition to adopt a mesenchymal-like fate, e.g. to become smooth muscle cells, osteoblasts, fibroblasts, or chondrocytes. In embryonic heart development, the importance of EndMT was established several decades ago, with ECs undergoing EndMT to give rise to the endocardial cushions that ultimately develop into the cardiac valves. More recently, EndMT has been observed in various adult cardiovascular diseases. T",{"id":119,"funder":7,"programme":8,"title":120,"piName":121,"institution":26,"country":12,"year":13,"amount":14,"abstract":122},"openalex-nederlandse-organisatie-voor-wetenschapp-award-scientific-research-vici-grant-no-17854","Unobtrusive inference of diurnal rhythms from smartphone data","Loran Knol","Diurnal rhythms are an integral feature of psychopathology but difficult to measure at scale. Smartphones are ubiquitous and therefore uniquely positioned to measure such rhythms non-invasively and continuously. Here, we propose a digital phenotyping framework to quantify diurnal rhythms. We use it to predict sleep duration from smartphone typing dynamics and analyse rhythm phase during time zone transitions with a clinical outpatient sample and a year-long longitudinal data set.",{"id":124,"funder":7,"programme":8,"title":125,"piName":126,"institution":127,"country":12,"year":13,"amount":14,"abstract":128},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vici-185-050","Psilocybin alters visual contextual computations","Marco Aqil","Netherlands Institute for Neuroscience","Psilocybin alters perception and brain dynamics. Here, we investigate the effects of psilocybin using psychophysics, ultra-high field functional MRI, and computational modeling. We find that psilocybin alters contextual perception in the Ebbinghaus illusion, as well as contextual modulation in cortical responses to visual stimuli. We propose a computational model capable of capturing and linking these changes. Leveraging vision as a beachhead, our findings highlight the alteration of contextual ",{"id":130,"funder":7,"programme":8,"title":125,"piName":126,"institution":127,"country":12,"year":13,"amount":14,"abstract":128},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-016-vici-185-050-to-sd",23,{"programme":8,"total":133,"withPiName":133,"firstYear":134,"lastYear":135,"countryCount":136,"perYear":137,"topInstitutions":182,"topCountries":230},296,2008,2026,18,[138,140,142,144,147,150,153,156,159,162,165,167,170,173,176,179,180],{"year":134,"count":139},1,{"year":141,"count":139},2011,{"year":143,"count":139},2012,{"year":145,"count":146},2013,3,{"year":148,"count":149},2014,4,{"year":151,"count":152},2015,7,{"year":154,"count":155},2016,14,{"year":157,"count":158},2017,44,{"year":160,"count":161},2018,65,{"year":163,"count":164},2019,9,{"year":166,"count":136},2020,{"year":168,"count":169},2021,16,{"year":171,"count":172},2022,22,{"year":174,"count":175},2023,27,{"year":177,"count":178},2024,26,{"year":13,"count":131},{"year":135,"count":181},15,[183,185,187,188,189,191,192,194,196,199,200,202,204,206,208,210,211,213,215,217,220,222,224,226,228],{"name":11,"count":184},40,{"name":26,"count":186},24,{"name":52,"count":172},{"name":37,"count":172},{"name":109,"count":190},20,{"name":66,"count":181},{"name":20,"count":193},13,{"name":195,"count":152},"University of Groningen",{"name":197,"count":198},"Amsterdam Neuroscience",6,{"name":87,"count":198},{"name":201,"count":198},"University Medical Center Utrecht",{"name":127,"count":203},5,{"name":205,"count":203},"University of Twente",{"name":207,"count":149},"Delft University of Technology",{"name":209,"count":149},"Institute for Atomic and Molecular Physics",{"name":60,"count":149},{"name":212,"count":149},"Wageningen University & Research",{"name":214,"count":146},"Broad Institute",{"name":216,"count":146},"The Netherlands Cancer Institute",{"name":218,"count":219},"Academic Medical Center",2,{"name":221,"count":219},"Amsterdam UMC Location University of Amsterdam",{"name":223,"count":219},"Maastricht University",{"name":225,"count":219},"Oncode Institute",{"name":227,"count":219},"Radboud University Medical Center",{"name":229,"count":219},"Tilburg University",[231,233,236,238,239,241,243,245,246,248,250,252,254,256,258,260,262,264],{"name":12,"count":232},234,{"name":234,"count":235},"US",17,{"name":237,"count":203},"DE",{"name":116,"count":149},{"name":240,"count":146},"CH",{"name":242,"count":146},"IT",{"name":244,"count":219},"CA",{"name":81,"count":219},{"name":247,"count":139},"AT",{"name":249,"count":139},"AU",{"name":251,"count":139},"BE",{"name":253,"count":139},"BR",{"name":255,"count":139},"CN",{"name":257,"count":139},"CZ",{"name":259,"count":139},"IE",{"name":261,"count":139},"QA",{"name":263,"count":139},"RU",{"name":265,"count":139},"TH"]