[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2010":3,"awarded-stats-nwo-vidi":58},{"awarded":4,"total":57},[5,16,21,27,32,38,42,47,53],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vernieuwingsimpuls-vidi-grant-864-10-004","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth","Harrold A. van den Burg","University of Amsterdam","NL",2010,null,"Increased ambient temperature is inhibitory to plant immunity including auto-immunity. SNC1-dependent auto-immunity is, for example, fully suppressed at 28°C. We found that the Arabidopsis sumoylation mutant siz1 displays SNC1-dependent auto-immunity at 22°C but also at 28°C, which was EDS1 dependent at both temperatures. This siz1 auto-immune phenotype provided enhanced resistance to Pseudomonas at both temperatures. Moreover, the rosette size of siz1 recovered only weakly at 28°C, while this t",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":14,"country":12,"year":13,"amount":14,"abstract":20},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-vl-vidi-103-019","Future trends of desalination and wastewater treatment accounting for risks of maladaptation","Marina Andrijevic","The intensifying effects of climate change on global water scarcity require ensuring reliable, equitable, and sustainable water supply, with novel technologies becoming increasingly central to adaptation. In this study, we develop projections of wastewater treatment and desalination capacities and analyze their associated energy demand and CO 2 emissions. While technologically mature and rapidly expanding, their future development remains underexamined as a risk of maladaptation that stems from ",{"id":22,"funder":7,"programme":8,"title":23,"piName":24,"institution":25,"country":12,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-10-007","Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model","Ronit Shiri‐Sverdlov","Maastricht University","Non-alcoholic steatohepatitis (NASH) is a common liver disease characterized by hepatic lipid accumulation (steatosis) and inflammation. Currently, therapeutic options are poor and the long-term burden to society is constantly increasing. Previously, macrophage stimulating protein (MSP)-a serum protein mainly secreted by liver-was shown to inhibit oxidized low-density lipoprotein (OxLDL)\u002Flipopolysaccharides (LPS)-induced inflammation in mouse macrophages. Additionally, MSP could reduce palmitic ",{"id":28,"funder":7,"programme":8,"title":29,"piName":30,"institution":14,"country":12,"year":13,"amount":14,"abstract":31},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-10-012","Geographic variation in baseline innate immune function does not follow variation in aridity along a tropical environmental gradient","Chima J. Nwaogu","Geographic variation in aridity determines environmental productivity patterns, including large-scale variability in pathogens, vectors and associated diseases. If disease risk decreases with increasing aridity and is matched by immune defense, we predict a decrease in innate immune function along a gradient of increasing aridity from the cool-wet forest to the hot-dry Sahel, from south to north in Nigeria. We sampled blood and measured five innate immune indices from 286 Common Bulbuls Pycnonot",{"id":33,"funder":7,"programme":8,"title":34,"piName":35,"institution":36,"country":12,"year":13,"amount":14,"abstract":37},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-10-012","Gut microbiota of homing pigeons shows summer–winter variation under constant diet indicating a substantial effect of temperature","Maurine W. Dietz","University of Groningen","BACKGROUND: Gut microbiotas play a pivotal role in host physiology and behaviour, and may affect host life-history traits such as seasonal variation in host phenotypic state. Generally, seasonal gut microbiota variation is attributed to seasonal diet variation. However, seasonal temperature and day length variation may also drive gut microbiota variation. We investigated summer-winter differences in the gut bacterial community (GBC) in 14 homing pigeons living outdoors under a constant diet by c",{"id":39,"funder":7,"programme":8,"title":40,"piName":41,"institution":14,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-10-003","Practical observations on the use of fluorescent reporter systems in Clostridioides difficile","Ana M. Oliveira Paiva",{"id":43,"funder":7,"programme":8,"title":44,"piName":45,"institution":25,"country":12,"year":13,"amount":14,"abstract":46},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-10-007","2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes","Dipanjan Chanda","Several studies have linked impaired glucose uptake and insulin resistance (IR) to functional impairment of the heart. Recently, endocannabinoids have been implicated in cardiovascular disease. However, the mechanisms involving endocannabinoid signaling, glucose uptake, and IR in cardiomyocytes are understudied. Here we report that the endocannabinoid 2-arachidonoylglycerol (2-AG), via stimulation of cannabinoid type 1 (CB1) receptor and Ca\u003Csup>2+\u003C\u002Fsup>\u002Fcalmodulin-dependent protein kinase β, act",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":51,"country":12,"year":13,"amount":14,"abstract":52},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-10-008","Effects of admixture in native and invasive populations of Lythrum salicaria","Koen J. F. Verhoeven","Netherlands Institute of Ecology","Intraspecific hybridization between diverged populations can enhance fitness via various genetic mechanisms. The benefits of such admixture have been proposed to be particularly relevant in biological invasions, when invasive populations originating from different source populations are found sympatrically. However, it remains poorly understood if admixture is an important contributor to plant invasive success and how admixture effects compare between invasive and native ranges. Here, we used ex",{"id":54,"funder":7,"programme":8,"title":55,"piName":30,"institution":14,"country":12,"year":13,"amount":14,"abstract":56},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-10-012","Weak breeding seasonality of a songbird in a seasonally arid tropical environment arises from individual flexibility and strongly seasonal moult","In some tropical birds, breeding seasonality is weak at the population level, even where there are predictable seasonal peaks in environmental conditions. It therefore remains unclear whether individuals are adapted to breeding at specific times of the year or flexible to variable environmental conditions. We tested whether the relative year‐round breeding activity of the Common Bulbul Pycnonotus barbatus arises due to within‐individual variability in breeding dates. We collected data from 827 b",9,{"programme":8,"total":59,"withPiName":59,"firstYear":60,"lastYear":61,"countryCount":62,"perYear":63,"topInstitutions":123,"topCountries":183},822,2002,2026,1,[64,65,68,70,73,76,77,80,83,86,89,92,95,98,101,104,107,110,113,116,119,122],{"year":60,"count":62},{"year":66,"count":67},2006,2,{"year":69,"count":62},2007,{"year":71,"count":72},2008,3,{"year":74,"count":75},2009,8,{"year":13,"count":57},{"year":78,"count":79},2011,10,{"year":81,"count":82},2012,14,{"year":84,"count":85},2013,22,{"year":87,"count":88},2014,16,{"year":90,"count":91},2015,11,{"year":93,"count":94},2016,32,{"year":96,"count":97},2017,77,{"year":99,"count":100},2018,163,{"year":102,"count":103},2019,137,{"year":105,"count":106},2020,82,{"year":108,"count":109},2021,73,{"year":111,"count":112},2022,55,{"year":114,"count":115},2023,38,{"year":117,"count":118},2024,39,{"year":120,"count":121},2025,19,{"year":61,"count":79},[124,127,130,132,134,136,139,142,145,147,149,151,153,156,159,161,163,165,167,169,172,174,176,178,181],{"name":125,"count":126},"Utrecht University",65,{"name":128,"count":129},"Radboud University Nijmegen",64,{"name":36,"count":131},53,{"name":11,"count":133},41,{"name":135,"count":115},"Leiden University",{"name":137,"count":138},"Wageningen University & Research",29,{"name":140,"count":141},"Delft University of Technology",28,{"name":143,"count":144},"Eindhoven University of Technology",20,{"name":146,"count":144},"Erasmus MC",{"name":148,"count":144},"University Medical Center Groningen",{"name":25,"count":150},18,{"name":152,"count":88},"Erasmus University Rotterdam",{"name":154,"count":155},"Vrije Universiteit Amsterdam",15,{"name":157,"count":158},"Amsterdam Neuroscience",12,{"name":160,"count":158},"Leiden University Medical Center",{"name":162,"count":158},"University Medical Center Utrecht",{"name":164,"count":57},"University of Twente",{"name":166,"count":75},"Institute for Atomic and Molecular Physics",{"name":51,"count":168},7,{"name":170,"count":171},"Amsterdam University of Applied Sciences",6,{"name":173,"count":171},"Netherlands Institute for Neuroscience",{"name":175,"count":171},"The Netherlands Cancer Institute",{"name":177,"count":171},"Tilburg University",{"name":179,"count":180},"Amsterdam University Medical Centers",5,{"name":182,"count":180},"Royal Netherlands Institute for Sea Research",[184],{"name":12,"count":59}]