[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2015":3,"awarded-stats-nwo-vidi":93},{"awarded":4,"total":92},[5,16,22,29,34,38,43,47,52,58,64,70,74,80,86],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-452-08-001","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","Modelling non‐normal data: The relationship between the skew‐normal factor model and the quadratic factor model","Iris A. M. Smits","University of Groningen","NL",2015,null,"Maximum likelihood estimation of the linear factor model for continuous items assumes normally distributed item scores. We consider deviations from normality by means of a skew-normally distributed factor model or a quadratic factor model. We show that the item distributions under a skew-normal factor are equivalent to those under a quadratic model up to third-order moments. The reverse only holds if the quadratic loadings are equal to each other and within certain bounds. We illustrate that obs",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-11-008","Seismic signature of a hydrous mantle transition zone","Laura Cobden","Utrecht University","Although water has a major influence on tectonic and other geodynamic processes, little is known about its quantity and distribution within the deep Earth. In the last few decades, laboratory experiments on nominally anhydrous minerals (NAMs) of the transition zone have shown that these minerals can contain significant amounts of water, up to 3.3 wt%. In this study, we investigate if it is possible to use seismic observations to distinguish between a hydrous and anhydrous transition zone. We per",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-276-20-013","Transition Semantics for Branching Time","Antje Rumberg","University of Konstanz","DE","In this paper we develop a novel propositional semantics based on the framework of branching time. The basic idea is to replace the moment-history pairs employed as parameters of truth in the standard Ockhamist semantics by pairs consisting of a moment and a consistent, downward closed set of so-called transitions. Whereas histories represent complete possible courses of events, sets of transitions can represent incomplete parts thereof as well. Each transition captures one of the alternative im",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-12-014","Within-strain variation in behavior differs consistently between common inbred strains of mice","Maarten Loos","Sylics (Netherlands)",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-number-vidi-project-864-07-007","A sampling formula for ecological communities with multiple dispersal syndromes","Thijs Janzen",{"id":39,"funder":7,"programme":8,"title":40,"piName":41,"institution":42,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91712329","To target or not to target viral antigens in HBV related HCC?","Andrea M. Woltman","Erasmus MC",{"id":44,"funder":7,"programme":8,"title":45,"piName":46,"institution":11,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-project-grant-no-10284-","Protocol optimization for the mild detemplation of mesoporous silica nanoparticles resulting in enhanced texture and colloidal stability","Ignacio Melián‐Cabrera",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":11,"country":12,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-126-307","Airway and Extracellular Matrix Mechanics in COPD","Reinoud Gosens","Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases worldwide, and is characterized by airflow obstruction that is not fully reversible with treatment. Even though airflow obstruction is caused by airway smooth muscle contraction, the extent of airway narrowing depends on a range of other structural and functional determinants that impact on active and passive tissue mechanics. Cells and extracellular matrix in the airway and parenchymal compartments respond both",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":56,"country":12,"year":13,"amount":14,"abstract":57},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-09-005","Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity","Juliette Legler","Vrije Universiteit Amsterdam","The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipogenesis, and obesity and evaluate the zebrafish as an emerging vertebrate model to study the function of PPARs. Zebrafish are an appropriate model to study human diseases, including o",{"id":59,"funder":7,"programme":8,"title":60,"piName":61,"institution":62,"country":12,"year":13,"amount":14,"abstract":63},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-13-007","Cold-water coral reefs and adjacent sponge grounds: hotspots of benthic respiration and organic carbon cycling in the deep sea","Cécile Cathalot","Royal Netherlands Institute for Sea Research","Cold-water coral reefs and adjacent sponge grounds are distributed widely in the deep ocean, where only a small fraction of the surface productivity reaches the seafloor as detritus. It remains elusive how these hotspots of biodiversity can thrive in such a food-limited environment, as data on energy flow and organic carbon utilization are critically lacking. Here we report in situ community respiration rates for cold-water coral and sponge ecosystems obtained by the non-invasive aquatic Eddy Co",{"id":65,"funder":7,"programme":8,"title":66,"piName":67,"institution":68,"country":12,"year":13,"amount":14,"abstract":69},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-cw-723-013-007","Single molecule detection with graphene and other two-dimensional materials: nanopores and beyond","Grégory F. Schneider","Leiden University","Graphene and other two dimensional (2D) materials are currently integrated into nanoscaled devices that may - one day - sequence genomes. The challenge to solve is conceptually straightforward: cut a sheet out of a 2D material and use the edge of the sheet to scan an unfolded biomolecule from head to tail. As the scan proceeds - and because 2D materials are atomically thin - the information provided by the edge might be used to identify different segments - ideally single nucleotides - in the bi",{"id":71,"funder":7,"programme":8,"title":72,"piName":73,"institution":11,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-11-010","Diversity and trust: The role of shared values","Mariko J. Klasing",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":12,"year":13,"amount":14,"abstract":79},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vidi-016-136-308","The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids","Jingyuan Fu","TiFN","Our studies suggest that the gut microbiome may play an important role in the variation in body mass index and blood lipid levels, independent of age, sex, and host genetics. Our findings support the potential of therapies altering the gut microbiome to control body mass, triglycerides, and high-density lipoproteins.",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":84,"country":12,"year":13,"amount":14,"abstract":85},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-96-307","Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy","Kelly Kersten","The Netherlands Cancer Institute","Cancer immunotherapy is gaining momentum in the clinic. The current challenge is to understand why a proportion of cancer patients do not respond to cancer immunotherapy, and how this can be translated into the rational design of combinatorial cancer immunotherapy strategies aimed at maximizing success of immunotherapy. Here, we discuss how tumors orchestrate an immunosuppressive microenvironment, which contributes to their escape from immune attack. Relieving the immunosuppressive networks in c",{"id":87,"funder":7,"programme":8,"title":88,"piName":89,"institution":90,"country":12,"year":13,"amount":14,"abstract":91},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-096-397","Validation of a simple response-time measure of listening effort","Carina Pals","University Medical Center Groningen","This study compares two response-time measures of listening effort that can be combined with a clinical speech test for a more comprehensive evaluation of total listening experience; verbal response times to auditory stimuli (RTaud) and response times to a visual task (RTsvis) in a dual-task paradigm. The listening task was presented in five masker conditions; no noise, and two types of noise at two fixed intelligibility levels. Both the RTsaud and RTsvis showed effects of noise. However, only R",15,{"programme":8,"total":94,"withPiName":94,"firstYear":95,"lastYear":96,"countryCount":97,"perYear":98,"topInstitutions":148,"topCountries":206},788,2008,2026,33,[99,101,104,106,109,112,115,116,119,122,125,128,131,134,137,140,143,146],{"year":95,"count":100},1,{"year":102,"count":103},2009,2,{"year":105,"count":100},2011,{"year":107,"count":108},2012,3,{"year":110,"count":111},2013,5,{"year":113,"count":114},2014,6,{"year":13,"count":92},{"year":117,"count":118},2016,41,{"year":120,"count":121},2017,58,{"year":123,"count":124},2018,114,{"year":126,"count":127},2019,28,{"year":129,"count":130},2020,39,{"year":132,"count":133},2021,34,{"year":135,"count":136},2022,37,{"year":138,"count":139},2023,66,{"year":141,"count":142},2024,116,{"year":144,"count":145},2025,133,{"year":96,"count":147},89,[149,151,154,156,159,160,162,165,167,170,171,173,176,178,181,183,186,189,191,194,196,198,200,202,203],{"name":20,"count":150},63,{"name":152,"count":153},"Radboud University Nijmegen",60,{"name":11,"count":155},52,{"name":157,"count":158},"University of Amsterdam",40,{"name":68,"count":136},{"name":161,"count":127},"Delft University of Technology",{"name":163,"count":164},"Wageningen University & Research",25,{"name":90,"count":166},19,{"name":168,"count":169},"Eindhoven University of Technology",17,{"name":42,"count":169},{"name":172,"count":169},"Maastricht University",{"name":174,"count":175},"Erasmus University Rotterdam",16,{"name":56,"count":177},14,{"name":179,"count":180},"Amsterdam Neuroscience",12,{"name":182,"count":180},"University Medical Center Utrecht",{"name":184,"count":185},"Leiden University Medical Center",11,{"name":187,"count":188},"Centre National de la Recherche Scientifique",8,{"name":190,"count":188},"Institute for Atomic and Molecular Physics",{"name":192,"count":193},"Netherlands Institute of Ecology",7,{"name":195,"count":193},"University of Twente",{"name":197,"count":114},"Amsterdam University of Applied Sciences",{"name":199,"count":114},"Netherlands Institute for Neuroscience",{"name":201,"count":114},"Tilburg University",{"name":62,"count":111},{"name":204,"count":205},"Amsterdam University Medical Centers",4,[207,209,211,214,217,220,223,225,227,229,231,233,235,237,239,241,243,245,247,249,251,253,255,257,259],{"name":12,"count":208},558,{"name":27,"count":210},30,{"name":212,"count":213},"US",27,{"name":215,"count":216},"GB",21,{"name":218,"count":219},"FR",13,{"name":221,"count":222},"BE",9,{"name":224,"count":222},"CH",{"name":226,"count":188},"IT",{"name":228,"count":193},"CN",{"name":230,"count":111},"AU",{"name":232,"count":111},"CA",{"name":234,"count":111},"DK",{"name":236,"count":111},"ES",{"name":238,"count":205},"AT",{"name":240,"count":205},"BR",{"name":242,"count":108},"IE",{"name":244,"count":103},"HU",{"name":246,"count":103},"PL",{"name":248,"count":103},"SE",{"name":250,"count":103},"SG",{"name":252,"count":103},"ZA",{"name":254,"count":100},"AE",{"name":256,"count":100},"AR",{"name":258,"count":100},"BD",{"name":260,"count":100},"CL"]