[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2017":3,"awarded-stats-nwo-vidi":328},{"awarded":4,"total":327},[5,16,23,29,35,40,45,52,58,62,68,73,78,85,88,93,99,104,110,116,121,126,132,134,140,145,151,157,163,165,171,176,182,187,192,196,202,207,213,219,225,230,235,240,245,252,257,262,268,274,280,286,291,296,303,308,314,321],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-680-47-515","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET","Thomas Shimizu","Institute for Atomic and Molecular Physics","NL",2017,null,"chemotaxis system that reveal pervasive signaling variability, both across cells in isogenic populations and within individual cells over time. We quantify cell-to-cell variability of adaptation, ligand response, as well as steady-state output level, and analyze the role of network design in shaping this diversity from gene expression noise. In the absence of changes in gene expression, we find that single cells demonstrate strong temporal fluctuations. We provide evidence that such signaling no",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-no-723-014-009","Nonadiabatic Vibrational Damping of Molecular Adsorbates: Insights into Electronic Friction and the Role of Electronic Coherence","Karsten Reuter","Technical University of Munich","DE","We present a perturbation approach rooted in time-dependent density-functional theory to calculate electron-hole (e-h) pair excitation spectra during the nonadiabatic vibrational damping of adsorbates on metal surfaces. Our analysis for the benchmark systems CO on Cu(100) and Pt(111) elucidates the surprisingly strong influence of rather short electronic coherence times. We demonstrate how in the limit of short electronic coherence times, as implicitly assumed in prevalent quantum nuclear theori",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":12,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-2013","Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure","Catherijne A. J. Knibbe","Leiden University","AIMS: Inflammation and organ failure have been reported to have an impact on cytochrome P450 (CYP) 3A-mediated clearance of midazolam in critically ill children. Our aim was to evaluate a previously developed population pharmacokinetic model both in critically ill children and other populations, in order to allow the model to be used to guide dosing in clinical practice. METHODS: and 0-4 failing organs) using graphical and numerical diagnostics. RESULTS: The pharmacokinetic model predicted midaz",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91-776-384","What can Cortical Development in Attention-Deficit\u002FHyperactivity Disorder Teach us About the Early Developmental Mechanisms Involved?","Sara Ambrosino","University Medical Center Utrecht","Studies of Attention-Deficit\u002FHyperactivity Disorder (ADHD) have shown developmental changes in the cortical mantle. Different dimensions of cortical morphology, such as surface area and thickness, relate to different neurodevelopmental mechanisms. As such, studying multiple dimensions may inform us about the developmental origins of ADHD. Furthermore, results from existing longitudinal samples await replication. Therefore, we conducted a longitudinal study of multiple cortical dimensions in a si",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-bb-000448-1-vidi","Modelling asymmetric somitogenesis: Deciphering the mechanisms behind species differences","Renske M. A. Vroomans","Utrecht University",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":27,"country":12,"year":13,"amount":14,"abstract":44},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-145-360-","The association between child maltreatment and emotional, cognitive, and physical health functioning in Vietnam","Lenneke R. A. Alink","BACKGROUND: There is a paucity of research on correlates of child maltreatment in limited-resource countries with a relatively high tolerance of harsh discipline. This Vietnamese study aimed to investigate associations between different types of child maltreatment and child emotional, cognitive, and physical health functioning as well as moderation effects of gender and ethnicity. METHODS: This cross-sectional study was conducted with 1851 randomly selected students aged 12-17 years. Both self-r",{"id":46,"funder":7,"programme":8,"title":47,"piName":48,"institution":49,"country":50,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-700-10-427","The Rich Solid-State Phase Behavior of \u003Cscp>dl\u003C\u002Fscp>-Aminoheptanoic Acid: Five Polymorphic Forms and Their Phase Transitions","Simon J. Coles","University of Southampton","GB","High Resolution Image Download MS PowerPoint Slide The rich landscape of enantiotropically related polymorphic forms and their solid-state phase transitions of dl -2-aminoheptanoic acid ( dl -AHE) has been explored using a range of complementary characterization techniques, and is largely exemplary of the polymorphic behavior of linear aliphatic amino acids. As many as five new polymorphic forms were found, connected by four fully reversible solid-state phase transitions. Two low temperature for",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":56,"country":12,"year":13,"amount":14,"abstract":57},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vidi-016-126-358","Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies","Frank Stassen","Maastricht University Medical Centre","Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted molecules for proteomic and functional studies. Conditioned media of BEAS-2B bronchial epithelial cells were concentrated on 10 kDa centrifuge filters, followed by separation of EV",{"id":59,"funder":7,"programme":8,"title":60,"piName":61,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-52-07-008","Exogenous testosterone affects early threat processing in socially anxious and healthy women","Jacobien M. van Peer",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":66,"country":12,"year":13,"amount":14,"abstract":67},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-136-367","Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study","Jessica C. Kiefte–de Jong","Hague Institute for Global Justice","We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of vegetable origin and if intake of dietary fibre was high. INTRODUCTION: Studies on dietary acid load (DAL) and fractures have shown inconsistent results. Associations between DAL, bone mineral density (BMD) and trabecular bone integrity ",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":14,"country":14,"year":13,"amount":14,"abstract":72},"openalex-nederlandse-organisatie-voor-wetenschapp-award-12365","Mass transfer phenomena in fluidized beds with horizontally immersed membranes","M Martin van Sint Annaland","ACKNOWLEDGEMENTS. The authors are grateful to TTW and NWO for their financial support through the VIDI project ClingCO2, project number 12365.",{"id":74,"funder":7,"programme":8,"title":75,"piName":76,"institution":77,"country":21,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-14-006","Root chemistry and soil fauna, but not soil abiotic conditions explain the effects of plant diversity on root decomposition","Hongmei Chen","Leipzig University",{"id":79,"funder":7,"programme":8,"title":80,"piName":81,"institution":82,"country":83,"year":13,"amount":14,"abstract":84},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-76-365","Faculty Opinions recommendation of TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine.","William W. Agace","Lund University","SE","CD103 + CD11b + dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFR1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103 + CD11b + DCs and a reciprocal increase in the CD103 -CD11b + dendritic cell subset. Transcriptional profiling identifies markers that define the CD103 + CD11b + DC line",{"id":86,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":12,"year":13,"amount":14,"abstract":87},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-2013-caj-knibbe-","The recently published pharmacokinetic model for midazolam, quantifying the influence of maturation, inflammation and organ failure in children, yields unbiased clearance predictions and can therefore be used for dosing instructions in term neonates, children and adults with varying levels of critical illness, including healthy adults, but not for extrapolation to preterm neonates.",{"id":89,"funder":7,"programme":8,"title":90,"piName":91,"institution":39,"country":12,"year":13,"amount":14,"abstract":92},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-10-007","Discrete- vs. Continuous-Time Modeling of Unequally Spaced Experience Sampling Method Data","Silvia de Haan-Rietdijk","The Experience Sampling Method is a common approach in psychological research for collecting intensive longitudinal data with high ecological validity. One characteristic of ESM data is that it is often unequally spaced, because the measurement intervals within a day are deliberately varied, and measurement continues over several days. This poses a problem for discrete-time (DT) modeling approaches, which are based on the assumption that all measurements are equally spaced. Nevertheless, DT appr",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":97,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-014-008","Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine","Dirk Jan Slotboom","University of Groningen","We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane prot",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":97,"country":12,"year":13,"amount":14,"abstract":103},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-13476","Charge Carrier Extraction in Organic Solar Cells Governed by Steady‐State Mobilities","Vincent M. Le Corre","Abstract Charge transport in organic photovoltaic (OPV) devices is often characterized by steady‐state mobilities. However, the suitability of steady‐state mobilities to describe charge transport has recently been called into question, and it has been argued that dispersion plays a significant role. In this paper, the importance of the dispersion of charge carrier motion on the performance of organic photovoltaic devices is investigated. An experiment to measure the charge extraction time under ",{"id":105,"funder":7,"programme":8,"title":106,"piName":107,"institution":108,"country":12,"year":13,"amount":14,"abstract":109},"openalex-nederlandse-organisatie-voor-wetenschapp-award-ici-024-002-009-vidi-864-14-001","Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes","Frans Bianchi","Radboud Institute for Molecular Life Sciences","About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to major histocompatibility complex (MHC) class I. It, therefore, comes as no surprise that bioinformatics analysis predicts an over-representation of TMHs among strong MHC class I (MHC-I) binders. Published peptide elution studies confirm that TMHs ar",{"id":111,"funder":7,"programme":8,"title":112,"piName":113,"institution":114,"country":12,"year":13,"amount":14,"abstract":115},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-012-105","Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Challenge 2","Eko Aditya Rifai","Vrije Universiteit Amsterdam","Computational protein binding affinity prediction can play an important role in drug research but performing efficient and accurate binding free energy calculations is still challenging. In the context of phase 2 of the Drug Design Data Resource (D3R) Grand Challenge 2 we used our automated eTOX ALLIES approach to apply the (iterative) linear interaction energy (LIE) method and we evaluated its performance in predicting binding affinities for farnesoid X receptor (FXR) agonists. Efficiency was o",{"id":117,"funder":7,"programme":8,"title":118,"piName":119,"institution":97,"country":12,"year":13,"amount":14,"abstract":120},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-016-126-307","β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein\u002Fp300 in Human Airway Smooth Muscle","Reinoud Gosens","β-Catenin is a multifunctional protein that apart from its role in proliferative and differentiation events, also acts upon inflammatory processes, mainly \u003Ci>via\u003C\u002Fi> interaction with nuclear factor-κB (NF-κB). However, there is still controversy as to whether β-catenin facilitates or represses NF-κB output. Insights into the molecular mechanisms underlying the interaction between β-catenin and NF-κB have highlighted the cofactors CREB-binding protein (CBP) and p300 as important candidates. Here,",{"id":122,"funder":7,"programme":8,"title":123,"piName":124,"institution":27,"country":12,"year":13,"amount":14,"abstract":125},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-13-010-","A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials","Guangchao Chen","Gathering required information in a fast and inexpensive way is essential for assessing the risks of engineered nanomaterials (ENMs). The extension of conventional (quantitative) structure-activity relationships ((Q)SARs) approach to nanotoxicology, i.e., nano-(Q)SARs, is a possible solution. The preliminary attempts of correlating ENMs' characteristics to the biological effects elicited by ENMs highlighted the potential applicability of (Q)SARs in the nanotoxicity field. This review discusses t",{"id":127,"funder":7,"programme":8,"title":128,"piName":129,"institution":130,"country":12,"year":13,"amount":14,"abstract":131},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016126355","The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes","Jeroen E. J. Guikema","Academic Medical Center","Lymphocytes are endowed with unique and specialized enzymatic mutagenic properties that allow them to diversify their antigen receptors, which are crucial sensors for pathogens and mediators of adaptive immunity. During lymphocyte development, the antigen receptors expressed by B and T lymphocytes are assembled in an antigen-independent fashion by ordered variable gene segment recombinations (V(D)J recombination), which is a highly ordered and regulated process that requires the recombination ac",{"id":133,"funder":7,"programme":8,"title":128,"piName":129,"institution":130,"country":12,"year":13,"amount":14,"abstract":131},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016126355",{"id":135,"funder":7,"programme":8,"title":136,"piName":137,"institution":138,"country":12,"year":13,"amount":14,"abstract":139},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-n-452-11-015","Basic Emotions in Human Neuroscience: Neuroimaging and Beyond","Marco Tamietto","Tilburg University","The existence of so-called 'basic emotions' and their defining attributes represents a long lasting and yet unsettled issue in psychology. Recently, neuroimaging evidence, especially related to the advent of neuroimaging meta-analytic methods, has revitalized this debate in the endeavor of systems and human neuroscience. The core theme focuses on the existence of unique neural bases that are specific and characteristic for each instance of basic emotion. Here we review this evidence, outlining c",{"id":141,"funder":7,"programme":8,"title":142,"piName":143,"institution":33,"country":12,"year":13,"amount":14,"abstract":144},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-639-072-411-to-al","Learning Morse Code Alters Microstructural Properties in the Inferior Longitudinal Fasciculus: A DTI Study","Lara Schlaffke","Learning relies on neuroplasticity, which has mainly been studied in gray matter (GM). However, there is mounting evidence indicating a critical role of white matter changes involved in learning processes. One of the most important learning processes in human development is language acquisition. However, due to the length of this learning process, it has been notoriously difficult to investigate the underlying neuroplastic changes. Here, we report a novel learning paradigm to assess the role of ",{"id":146,"funder":7,"programme":8,"title":147,"piName":148,"institution":149,"country":12,"year":13,"amount":14,"abstract":150},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-13-003","Alcohol-Related Knowledge and Alcohol-Related Norms in 4- to 6-Year-Olds-Evidence from the Dutch Electronic Appropriate Beverage Task","Carmen Voogt","Radboud University Nijmegen","Four- to 6-year-olds already have knowledge about alcohol and its norms in adult culture. Insight into the development of children's alcohol-related knowledge and alcohol-related norms over time is required to investigate the transitions to alcohol expectancies, drinking motives, and alcohol initiation often occurring in adolescence.",{"id":152,"funder":7,"programme":8,"title":153,"piName":154,"institution":155,"country":12,"year":13,"amount":14,"abstract":156},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-zonmw-vidi-016-136-367","Osteoporotic Vertebral Fracture Prevalence Varies Widely Between Qualitative and Quantitative Radiological Assessment Methods: The Rotterdam Study","Fernando Rivadeneira","DSM (Netherlands)","Accurate diagnosis of vertebral osteoporotic fractures is crucial for the identification of individuals at high risk of future fractures. Different methods for radiological assessment of vertebral fractures exist, but a gold standard is lacking. The aim of our study was to estimate statistical measures of agreement and prevalence of osteoporotic vertebral fractures in the population-based Rotterdam Study, across two assessment methods. The quantitative morphometry assisted by SpineAnalyzer® (QM ",{"id":158,"funder":7,"programme":8,"title":159,"piName":160,"institution":161,"country":12,"year":13,"amount":14,"abstract":162},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-916-76062","Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells","Marcel A.T.M. van Vugt","University Medical Center Groningen","Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to tumorigenesis. HR-deficient cancers are hypersensitive to Poly (ADP ribose)-polymerase (PARP) inhibitors, but can acquire resistance and relapse. Mechanistic understanding how PARP inhibition induces cytotoxicity in HR-deficient cancer cells is incomplete. Here we find PARP inhibition to compromise replication fork stability in HR-deficient cancer cells, leading to mitotic DNA damage and consequent chromatin bridges a",{"id":164,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91776384",{"id":166,"funder":7,"programme":8,"title":167,"piName":168,"institution":169,"country":12,"year":13,"amount":14,"abstract":170},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-016-156-415","Connectopic mapping with resting-state fMRI","Koen V. Haak","Radboud University Medical Center","Brain regions are often topographically connected: nearby locations within one brain area connect with nearby locations in another area. Mapping these connection topographies, or 'connectopies' in short, is crucial for understanding how information is processed in the brain. Here, we propose principled, fully data-driven methods for mapping connectopies using functional magnetic resonance imaging (fMRI) data acquired at rest by combining spectral embedding of voxel-wise connectivity 'fingerprint",{"id":172,"funder":7,"programme":8,"title":173,"piName":174,"institution":97,"country":12,"year":13,"amount":14,"abstract":175},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-11-011","Glucose limitation in \u003Ci>Lactococcus\u003C\u002Fi> shapes a single-peaked fitness landscape exposing membrane occupancy as a constraint","Claire E. Price","ABSTRACT A central theme in biology is to understand the molecular basis of fitness: which strategies succeed under which conditions; how are they mechanistically implemented; and which constraints shape trade-offs between alternative strategies. We approached these questions with parallel bacterial evolution experiments in chemostats. Chemostats provide a constant environment with a defined resource limitation (glucose), in which the growth rate can be controlled. Using Lactococcus lactis , we ",{"id":177,"funder":7,"programme":8,"title":178,"piName":179,"institution":180,"country":181,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-2009","Robust return risk measures","Fabio Bellini","University of Milano-Bicocca","IT",{"id":183,"funder":7,"programme":8,"title":184,"piName":185,"institution":97,"country":12,"year":13,"amount":14,"abstract":186},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-fellowship-864-12-001","High‐throughput CRISPRi phenotyping identifies new essential genes in \u003Ci>Streptococcus pneumoniae\u003C\u002Fi>","Xue Liu","Genome-wide screens have discovered a large set of essential genes in the opportunistic human pathogen Streptococcus pneumoniae. However, the functions of many essential genes are still unknown, hampering vaccine development and drug discovery. Based on results from transposon sequencing (Tn-seq), we refined the list of essential genes in S. pneumoniae serotype 2 strain D39. Next, we created a knockdown library targeting 348 potentially essential genes by CRISPR interference (CRISPRi) and show a",{"id":188,"funder":7,"programme":8,"title":189,"piName":190,"institution":39,"country":12,"year":13,"amount":14,"abstract":191},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-aspasia","Cognitive Advantages of Bilingual Children in Different Sociolinguistic Contexts","Elma Blom","Many studies have shown that bilingual children outperform monolinguals on tasks testing executive functioning, but other studies have not revealed any effect of bilingualism. In this study we compared three groups of bilingual children in the Netherlands, aged 6-7 years, with a monolingual control group. We were specifically interested in testing whether the bilingual cognitive advantage is modulated by the sociolinguistic context of language use. All three bilingual groups were exposed to a mi",{"id":193,"funder":7,"programme":8,"title":42,"piName":194,"institution":27,"country":12,"year":13,"amount":14,"abstract":195},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-145-360","Nhu K. Tran","Even in a culture in which harsh discipline is normative, child maltreatment was related to negative aspects of child wellbeing including emotional, cognitive, and physical health functioning. Efficient and low-cost interventions on child maltreatment should be developed and conducted in Vietnam as well as other countries with similar contexts.",{"id":197,"funder":7,"programme":8,"title":198,"piName":199,"institution":200,"country":12,"year":13,"amount":14,"abstract":201},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-639-072-309","De novo assembly of viral quasispecies using overlap graphs","Jasmijn A. Baaijens","Centrum Wiskunde & Informatica","A viral quasispecies, the ensemble of viral strains populating an infected person, can be highly diverse. For optimal assessment of virulence, pathogenesis, and therapy selection, determining the haplotypes of the individual strains can play a key role. As many viruses are subject to high mutation and recombination rates, high-quality reference genomes are often not available at the time of a new disease outbreak. We present SAVAGE, a computational tool for reconstructing individual haplotypes o",{"id":203,"funder":7,"programme":8,"title":204,"piName":205,"institution":27,"country":12,"year":13,"amount":14,"abstract":206},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-723-013-007","Hydrophilicity of Graphene in Water through Transparency to Polar and Dispersive Interactions","Grégory F. Schneider","Establishing contact angles on graphene-on-water has been a long-standing challenge as droplet deposition causes free-floating graphene to rupture. The current work presents ice and hydrogels as substrates mimicking water while offering a stable support for graphene. The lowest water contact angles on graphene ever measured, namely on graphene-on-ice and graphene-on-hydrogel, are recorded. The contact angle measurements of liquids with a range of polarities allow the transparency of graphene tow",{"id":208,"funder":7,"programme":8,"title":209,"piName":210,"institution":211,"country":12,"year":13,"amount":14,"abstract":212},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-h64-09-016","A Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice","Carlos P. Fitzsimons","University of Amsterdam","Lack of scientific reproducibility is a growing concern and weak experimental practices may contribute to irreproducibility. Here, we describe an optimized and versatile protocol for stereotaxic intrahippocampal administration of Kainic Acid (KA) in mice with a C57Bl6 background. In this protocol, KA administration is combined with \u003Ci>in vivo\u003C\u002Fi> recording of neuronal activity with wired and wireless setups. Following our protocol, KA administration results in a robust dose-dependent induction o",{"id":214,"funder":7,"programme":8,"title":215,"piName":216,"institution":217,"country":12,"year":13,"amount":14,"abstract":218},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-10-007","2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes","Dipanjan Chanda","Maastricht University","Several studies have linked impaired glucose uptake and insulin resistance (IR) to functional impairment of the heart. Recently, endocannabinoids have been implicated in cardiovascular disease. However, the mechanisms involving endocannabinoid signaling, glucose uptake, and IR in cardiomyocytes are understudied. Here we report that the endocannabinoid 2-arachidonoylglycerol (2-AG), via stimulation of cannabinoid type 1 (CB1) receptor and Ca\u003Csup>2+\u003C\u002Fsup>\u002Fcalmodulin-dependent protein kinase β, act",{"id":220,"funder":7,"programme":8,"title":221,"piName":222,"institution":223,"country":12,"year":13,"amount":14,"abstract":224},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-11-319","Chronotypes and circadian timing in migraine","WPJ van Oosterhout","Leiden University Medical Center","Background It has been suggested that migraine attacks strike according to circadian patterns and that this might be related to individual chronotype. Here we evaluated and correlated individual chronotypes, stability of the circadian rhythm, and circadian attack timing in a large and well-characterised migraine population. Methods In 2875 migraine patients and 200 non-headache controls we assessed differences in: (i) distribution of chronotypes (Münich Chronotype Questionnaire); (ii) the circad",{"id":226,"funder":7,"programme":8,"title":227,"piName":228,"institution":138,"country":12,"year":13,"amount":14,"abstract":229},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-project-number-452-11-012","Transparency and cooperation in repeated dilemma games: a meta study","Lenka Fiala","We use data from experiments on finitely repeated dilemma games with fixed matching to investigate the effect of different types of information on cooperation. The data come from 71 studies using the voluntary contributions paradigm, covering 122 data points, and from 18 studies on decision-making in oligopoly, covering another 50 data points. We find similar effects in the two sets of experimental games. We find that transparency about what everyone in a group earns reduces contributions to the",{"id":231,"funder":7,"programme":8,"title":232,"piName":233,"institution":130,"country":12,"year":13,"amount":14,"abstract":234},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-156-308","Balancing signals in the intestinal niche","Sanne M. van Neerven","During intestinal regeneration, opposing gradients of Wnt and BMP signaling ensure successful differentiation along the crypt\u002Fvillus axis. In this issue of The EMBO Journal , Horiguchi et al ( ) show how intestinal subepithelial myofibroblasts can influence cell fate decisions in the regenerating intestine via autocrine secretion of angiopoietin‐like protein 2 ( ANGPTL 2).",{"id":236,"funder":7,"programme":8,"title":237,"piName":238,"institution":39,"country":12,"year":13,"amount":14,"abstract":239},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-14-006","Application and Evaluation of an Expert Judgment Elicitation Procedure for Correlations","Mariëlle Zondervan‐Zwijnenburg","The purpose of the current study was to apply and evaluate a procedure to elicit expert judgments about correlations, and to update this information with empirical data. The result is a face-to-face group elicitation procedure with as its central element a trial roulette question that elicits experts' judgments expressed as distributions. During the elicitation procedure, a concordance probability question was used to provide feedback to the experts on their judgments. We evaluated the elicitati",{"id":241,"funder":7,"programme":8,"title":242,"piName":243,"institution":217,"country":12,"year":13,"amount":14,"abstract":244},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-013-009","Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging","Ingrid Dijkgraaf","As CD13 is selectively expressed in angiogenesis, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in vivo. The CD13-targeting moiety NGR was synthesized and cyclized by native chemical ligation (NCL) instead of disulfide bridging, leading to a cyclic peptide backbone: cyclo(Cys-Asn-Gly-Arg-Gly) (coNGR). Beside this new monomeric coNGR, a tetrameric NGR peptide co(NGR)\u003Csub>4\u003C\u002Fsub> was designed and synthesized. After radiolabeling, their in vi",{"id":246,"funder":7,"programme":8,"title":247,"piName":248,"institution":249,"country":250,"year":13,"amount":14,"abstract":251},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-number-723-013-004","Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy","Martin D. Witte","Indian Institute of Chemical Biology","IN","A method for identifying probe modification of proteins via tandem mass spectrometry was developed. Azide bearing molecules are immobilized on functionalised sepharose beads via copper catalysed Huisgen-type click chemistry and selectively released under acidic conditions by chemical cleavage of the triazene linkage. We applied this method to identify the modification site of targeted-diazotransfer on BirA.",{"id":253,"funder":7,"programme":8,"title":254,"piName":255,"institution":97,"country":12,"year":13,"amount":14,"abstract":256},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-171-047","Context-specific effects of genetic variants associated with autoimmune disease","Iris H. Jonkers","Autoimmune diseases such as rheumatoid arthritis and coeliac disease are typical examples of complex genetic diseases caused by a combination of genetic and non-genetic risk factors. Insight into the genetic risk factors (single nucleotide polymorphisms (SNPs)) has increased since genome-wide association studies (GWAS) became possible in 2007 and, for individual diseases, SNPs can now explain some 15-50% of genetic risk. GWAS have also shown that some 50% of the genetic risk factors for individu",{"id":258,"funder":7,"programme":8,"title":259,"piName":260,"institution":149,"country":12,"year":13,"amount":14,"abstract":261},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-156-363","Parietal cells—new perspectives in glomerular disease","Laura Miesen","In normal glomeruli, parietal epithelial cells (PECs) line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells (PTECs) at the urinary pole and with the podocytes at the vascular pole. PECs, PTECs and podocytes have a common mesenchymal origin and are the result of divergent differentiation during embryogenesis. Podocytes and PTECs are highly differentiated cells with well-established functions pertaining",{"id":263,"funder":7,"programme":8,"title":264,"piName":265,"institution":266,"country":12,"year":13,"amount":14,"abstract":267},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-012-102-","Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions","Truus E. M. Abbink","Amsterdam UMC Location VUmc","Vanishing white matter (VWM) is a leukodystrophy with predominantly early-childhood onset. Affected children display various neurological signs, including ataxia and spasticity, and die early. VWM patients have bi-allelic mutations in any of the five genes encoding the subunits of the eukaryotic translation factor 2B (eIF2B). eIF2B regulates protein synthesis rates under basal and cellular stress conditions. The underlying molecular mechanism of how mutations in eIF2B result in VWM is unknown. P",{"id":269,"funder":7,"programme":8,"title":270,"piName":271,"institution":272,"country":12,"year":13,"amount":14,"abstract":273},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-personal-grant-864-11-015","Microbial Volatiles: Small Molecules with an Important Role in Intra- and Inter-Kingdom Interactions","Paolina Garbeva","Netherlands Institute of Ecology","During the last decades, research on the function of volatile organic compounds focused primarily on the interactions between plants and insects. However, microorganisms can also release a plethora of volatiles and it appears that microbial volatile organic compounds (mVOCs) can play an important role in intra- and inter-kingdom interactions. So far, most studies are focused on aboveground volatile-mediated interactions and much less information is available about the function of volatiles below",{"id":275,"funder":7,"programme":8,"title":276,"piName":277,"institution":278,"country":50,"year":13,"amount":14,"abstract":279},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-639-042-524","Accretion Disks and Coronae in the X-Ray Flashlight","N. Degenaar","University of Cambridge","Plasma accreted onto the surface of a neutron star can ignite due to unstable thermonuclear burning and produce a bright flash of X-ray emission called a Type-I X-ray burst. Such events are very common; thousands have been observed to date from over a hundred accreting neutron stars. The intense, often Eddington-limited, radiation generated in these thermonuclear explosions can have a discernible effect on the surrounding accretion flow that consists of an accretion disk and a hot electron coron",{"id":281,"funder":7,"programme":8,"title":282,"piName":283,"institution":284,"country":12,"year":13,"amount":14,"abstract":285},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-zonmw-vidi-917-15-318","Impact of treatment on resting cerebral blood flow and metabolism in obsessive compulsive disorder: a meta-analysis","Anouk van der Straten","Amsterdam UMC Location University of Amsterdam","Neurobiological models of obsessive-compulsive disorder (OCD) posit that its clinical symptoms such as repetitive thoughts and behaviors are related to hyperactivity in the cortico-striato-thalamo-cortical (CSTC) circuit. Small scale neuroimaging studies have shown that treatment of OCD is associated with reduced activity across different brain structures within this circuitry. We performed the first meta-analysis of positron emission tomography (PET) and single photon emission computed tomograp",{"id":287,"funder":7,"programme":8,"title":288,"piName":289,"institution":39,"country":12,"year":13,"amount":14,"abstract":290},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-452-14-006","Proposal for a Five-Step Method to Elicit Expert Judgment","Duco Veen","Elicitation is a commonly used tool to extract viable information from experts. The information that is held by the expert is extracted and a probabilistic representation of this knowledge is constructed. A promising avenue in psychological research is to incorporated experts' prior knowledge in the statistical analysis. Systematic reviews on elicitation literature however suggest that it might be inappropriate to directly obtain distributional representations from experts. The literature qualif",{"id":292,"funder":7,"programme":8,"title":293,"piName":294,"institution":149,"country":12,"year":13,"amount":14,"abstract":295},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vidi-grant-864-11-006","C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37","Annemiek B. van Spriel","Abstract Cell migration is central to evoke a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2) expressed by DCs, with podoplanin expressed by lymph node stromal cells (LNSCs). However, the underlying molecular mechanisms by which CLEC-2 influences DC migration remain elusive. Here, we show that CLEC-2-dependent DC migration is tightly controlled by tetraspanin CD37, a membrane-organizing protein. Our fi",{"id":297,"funder":7,"programme":8,"title":298,"piName":299,"institution":300,"country":301,"year":13,"amount":14,"abstract":302},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-680-47-532","Global fits of GUT-scale SUSY models with GAMBIT","Peter Athron","Monash University","AU","We present the most comprehensive global fits to date of three supersymmetric models motivated by grand unification: the Constrained Minimal Supersymmetric Standard Model (CMSSM), and its Non-Universal Higgs Mass generalisations NUHM1 and NUHM2. We include likelihoods from a number of direct and indirect dark matter searches, a large collection of electroweak precision and flavour observables, direct searches for supersymmetry at LEP and Runs I and II of the LHC, and constraints from Higgs obser",{"id":304,"funder":7,"programme":8,"title":305,"piName":306,"institution":114,"country":12,"year":13,"amount":14,"abstract":307},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-452-09-007","You prime what you code: The fAIM model of priming of pop-out","Wouter Kruijne","Our visual brain makes use of recent experience to interact with the visual world, and efficiently select relevant information. This is exemplified by speeded search when target- and distractor features repeat across trials versus when they switch, a phenomenon referred to as intertrial priming. Here, we present fAIM, a computational model that demonstrates how priming can be explained by a simple feature-weighting mechanism integrated into an established model of bottom-up vision. In fAIM, such",{"id":309,"funder":7,"programme":8,"title":310,"piName":311,"institution":312,"country":21,"year":13,"amount":14,"abstract":313},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vici-grant-nr-453-13-006-vidi","Insights into Flood‐Coping Appraisals of Protection Motivation Theory: Empirical Evidence from Germany and France","Philip Bubeck","University of Potsdam","Protection motivation theory (PMT) has become a popular theory to explain the risk-reducing behavior of residents against natural hazards. PMT captures the two main cognitive processes that individuals undergo when faced with a threat, namely, threat appraisal and coping appraisal. The latter describes the evaluation of possible response measures that may reduce or avert the perceived threat. Although the coping appraisal component of PMT was found to be a better predictor of protective intentio",{"id":315,"funder":7,"programme":8,"title":316,"piName":317,"institution":318,"country":319,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-nr-452-11-005","Living in the Past or Living in the Future? Analyzing Parties’ Platform Change In Between Elections,The Netherlands 1997–2014","Mariken Anna Catharina Geertruida van der Velden","University of Zurich","CH","Do parties change their platform in anticipation of electoral losses? Or do parties respond to experienced losses at the previous election? These questions relate to two mechanisms to align public opinion with party platforms: (1) rational anticipation, and (2) electoral performance. While extant work empirically tested, and found support for, the latter mechanism, the effect of rational anticipation has not been put to an empirical test yet. We contribute to the literature on party platform cha",{"id":322,"funder":7,"programme":8,"title":323,"piName":324,"institution":325,"country":12,"year":13,"amount":14,"abstract":326},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-12-012","A Consistent Sea-Level Reconstruction and Its Budget on Basin and Global Scales over 1958–2014","Thomas Frederikse","Delft University of Technology","Abstract Different sea level reconstructions show a spread in sea level rise over the last six decades and it is not yet certain whether the sum of contributors explains the reconstructed rise. Possible causes for this spread are, among others, vertical land motion at tide-gauge locations and the sparse sampling of the spatially variable ocean. To assess these open questions, reconstructed sea level and the role of the contributors are investigated on a local, basin, and global scale. High-latit",58,{"programme":8,"total":329,"withPiName":329,"firstYear":330,"lastYear":331,"countryCount":332,"perYear":333,"topInstitutions":383,"topCountries":434},788,2008,2026,33,[334,336,339,341,344,347,350,353,356,357,360,363,366,369,372,375,378,381],{"year":330,"count":335},1,{"year":337,"count":338},2009,2,{"year":340,"count":335},2011,{"year":342,"count":343},2012,3,{"year":345,"count":346},2013,5,{"year":348,"count":349},2014,6,{"year":351,"count":352},2015,15,{"year":354,"count":355},2016,41,{"year":13,"count":327},{"year":358,"count":359},2018,114,{"year":361,"count":362},2019,28,{"year":364,"count":365},2020,39,{"year":367,"count":368},2021,34,{"year":370,"count":371},2022,37,{"year":373,"count":374},2023,66,{"year":376,"count":377},2024,116,{"year":379,"count":380},2025,133,{"year":331,"count":382},89,[384,386,388,390,392,393,394,397,399,402,404,405,408,410,413,414,416,419,420,422,424,426,428,429,431],{"name":39,"count":385},63,{"name":149,"count":387},60,{"name":97,"count":389},52,{"name":211,"count":391},40,{"name":27,"count":371},{"name":325,"count":362},{"name":395,"count":396},"Wageningen University & Research",25,{"name":161,"count":398},19,{"name":400,"count":401},"Eindhoven University of Technology",17,{"name":403,"count":401},"Erasmus MC",{"name":217,"count":401},{"name":406,"count":407},"Erasmus University Rotterdam",16,{"name":114,"count":409},14,{"name":411,"count":412},"Amsterdam Neuroscience",12,{"name":33,"count":412},{"name":223,"count":415},11,{"name":417,"count":418},"Centre National de la Recherche Scientifique",8,{"name":11,"count":418},{"name":272,"count":421},7,{"name":423,"count":421},"University of Twente",{"name":425,"count":349},"Amsterdam University of Applied Sciences",{"name":427,"count":349},"Netherlands Institute for Neuroscience",{"name":138,"count":349},{"name":430,"count":346},"Royal Netherlands Institute for Sea Research",{"name":432,"count":433},"Amsterdam University Medical Centers",4,[435,437,439,442,444,447,450,451,452,454,455,457,459,461,463,465,467,469,471,472,474,476,478,480,482],{"name":12,"count":436},558,{"name":21,"count":438},30,{"name":440,"count":441},"US",27,{"name":50,"count":443},21,{"name":445,"count":446},"FR",13,{"name":448,"count":449},"BE",9,{"name":319,"count":449},{"name":181,"count":418},{"name":453,"count":421},"CN",{"name":301,"count":346},{"name":456,"count":346},"CA",{"name":458,"count":346},"DK",{"name":460,"count":346},"ES",{"name":462,"count":433},"AT",{"name":464,"count":433},"BR",{"name":466,"count":343},"IE",{"name":468,"count":338},"HU",{"name":470,"count":338},"PL",{"name":83,"count":338},{"name":473,"count":338},"SG",{"name":475,"count":338},"ZA",{"name":477,"count":335},"AE",{"name":479,"count":335},"AR",{"name":481,"count":335},"BD",{"name":483,"count":335},"CL"]