[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2018":3,"awarded-stats-nwo-vidi":593},{"awarded":4,"total":592},[5,16,22,28,34,40,46,52,59,65,70,76,82,88,95,100,107,114,120,126,131,137,142,148,153,159,165,170,176,178,183,188,195,201,206,208,213,218,224,230,237,243,248,255,262,267,272,278,284,286,291,296,301,303,305,311,316,321,323,328,335,339,344,351,356,363,367,374,376,378,383,388,394,400,402,406,408,414,419,425,431,436,442,447,453,458,463,470,475,481,486,488,493,498,500,505,509,514,519,521,526,531,537,541,547,549,551,556,562,567,570,576,581,586],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-91714336","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","586Autogenous termination of atrial fibrillation in vivo through local gene delivery","Daniël A. Pijnappels","Leiden University Medical Center","NL",2018,null,"Funding Acknowledgements: NWO, Vidi grant 91714336 and ERC, Starting Grant 716509, both to D.A.P. Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased mortality, morbidity and impaired quality of life. Maintenance of sinus rhythm is the primary therapeutic goal for symptomatic AF patients but remains difficult to achieve because of suboptimal treatment options. While being effective in detecting and terminating AF, the use of implantable atr",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vidi-864-14-006","Linking ecology and plant pathology to unravel the importance of soil-borne fungal pathogens in species-rich grasslands","Liesje Mommer","Wageningen University & Research","Soil-borne fungal diseases are a major problem in agriculture. A century ago, the Dutch plant pathologist Johanna Westerdijk recognized the importance of linking fungal biology with ecology to understand plant disease dynamics. To explore new ways to manage soil-borne fungal disease in agriculture by ‘learning from nature’, we follow in her footsteps: we link below ground plant-fungal pathogen interactions to ecological settings, i.e. natural grasslands. Ecological research hypothesised that the",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-016-156-362","Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells","Mette D. Hazenberg","Amsterdam Neuroscience","Infusion of mesenchymal stromal cells (MSCs) is a promising and increasingly applied therapy for patients who suffer from a variety of inflammatory diseases, including graft-versus-host disease (GvHD), a common and life-threatening complication after allogeneic hematopoietic stem cell transplantation. The therapeutic effect of MSCs is mainly ascribed to their ability to suppress T cells and to support tissue repair. However, clinical response rates in patients with GvHD are limited to 50%, and t",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":12,"year":13,"amount":14,"abstract":33},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-no-452-11-011","From Poker Games to Kitchen Tables: How Social Dynamics Affect Frontline Decision Making","Nadine Raaphorst","Leiden University","Existing research on bureaucratic encounters typically studies how bureaucrats’ and clients’ characteristics influence frontline decision making. How social interactions between street-level bureaucrats and between officials and citizens could directly affect case-related decisions largely remains an underexplored field of study, despite the fact that new forms of governance introduce social dynamics in the form of trust and collaboration as tools to increase legitimacy. Relying on in-depth qual",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vernieuwingsimpuls-vidi-grant-864-10-004","The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth","Harrold A. van den Burg","University of Amsterdam","Increased ambient temperature is inhibitory to plant immunity including auto-immunity. SNC1-dependent auto-immunity is, for example, fully suppressed at 28°C. We found that the Arabidopsis sumoylation mutant siz1 displays SNC1-dependent auto-immunity at 22°C but also at 28°C, which was EDS1 dependent at both temperatures. This siz1 auto-immune phenotype provided enhanced resistance to Pseudomonas at both temperatures. Moreover, the rosette size of siz1 recovered only weakly at 28°C, while this t",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":12,"year":13,"amount":14,"abstract":45},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-126-358","Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles","Leon J. Schurgers","Maastricht University","The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary",{"id":47,"funder":7,"programme":8,"title":48,"piName":49,"institution":50,"country":12,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-149-312","Spatially Resolved Sensitivity of Single-Particle Plasmon Sensors","Peter Zijlstra","Eindhoven University of Technology","The high sensitivity of localized surface plasmon resonance sensors to the local refractive index allows for the detection of single-molecule binding events. Though binding events of single objects can be detected by their induced plasmon shift, the broad distribution of observed shifts remains poorly understood. Here, we perform a single-particle study wherein single nanospheres bind to a gold nanorod, and relate the observed plasmon shift to the binding location using correlative microscopy. T",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":56,"country":57,"year":13,"amount":14,"abstract":58},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-zonmw-vidi-0616-096-318","E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer","Valerie G. Brunton","Edinburgh Cancer Research","GB","Despite the fact that loss of E-cadherin is causal to the development and progression of invasive lobular carcinoma (ILC), options to treat this major breast cancer subtype are limited if tumours develop resistance to anti-oestrogen treatment regimens. This study aimed to identify clinically targetable pathways that are aberrantly active downstream of E-cadherin loss in ILC. Using a combination of reverse-phase protein array (RPPA) analyses, mRNA sequencing, conditioned medium growth assays and ",{"id":60,"funder":7,"programme":8,"title":61,"piName":62,"institution":63,"country":12,"year":13,"amount":14,"abstract":64},"openalex-nederlandse-organisatie-voor-wetenschapp-award--alw-vidi-864-12-008-","Probing aggrephagy using chemically-induced protein aggregates","Lukas C. Kapitein","Utrecht University","Selective types of autophagy mediate the clearance of specific cellular components and are essential to maintain cellular homeostasis. However, tools to directly induce and monitor such pathways are limited. Here we introduce the PIM (particles induced by multimerization) assay as a tool for the study of aggrephagy, the autophagic clearance of aggregates. The assay uses an inducible multimerization module to assemble protein clusters, which upon induction recruit ubiquitin, p62, and LC3 before b",{"id":66,"funder":7,"programme":8,"title":67,"piName":68,"institution":26,"country":12,"year":13,"amount":14,"abstract":69},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-91713354-","Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments","Maël Lebreton","Decisions are accompanied by a feeling of confidence, that is, a belief about the decision being correct. Confidence accuracy is critical, notably in high-stakes situations such as medical or financial decision-making. We investigated how incentive motivation influences confidence accuracy by combining a perceptual task with a confidence incentivization mechanism. By varying the magnitude and valence (gains or losses) of monetary incentives, we orthogonalized their motivational and affective com",{"id":71,"funder":7,"programme":8,"title":72,"piName":73,"institution":74,"country":12,"year":13,"amount":14,"abstract":75},"openalex-nederlandse-organisatie-voor-wetenschapp-award-91714302","210Genome-wide analysis reveals unique H3K27ac profile in acquired and inherited human myocardial remodelling","Folkert W. Asselbergs","University Medical Center Utrecht","Funding Acknowledgements: This work was supported by Netherlands Foundation for Cardiovascular Excellence (to C.C.), 2 NWO VIDI grants (no. 91714302 to C.C. and no. 016096359 t Introduction: The changing landscape of chromatin activity is a crucial factor in transcriptional gene regulation. It is an important hallmark of diseases, however it has not yet been investigated systematically in human remodelled myocardium. Purpose: To address this gap of knowledge, we aim to reveal genome-wide chromat",{"id":77,"funder":7,"programme":8,"title":78,"piName":79,"institution":80,"country":12,"year":13,"amount":14,"abstract":81},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-452-14-004","Why bright city lights dazzle and illuminate: A cognitive science approach to urban promises","Rodrigo Cardoso","Delft University of Technology","Despite the many uncertainties of life in cities, promises of economic prosperity, social mobility and happiness have fuelled the imagination of generations of urban migrants in search of a better life. Access to jobs, housing and amenities, and fewer restrictions of personal choices are some of the perceived advantages of cities, characterised here as ‘urban promises’. But while discourses celebrating the triumph of cities became increasingly common, urban rewards are not available everywhere a",{"id":83,"funder":7,"programme":8,"title":84,"piName":85,"institution":86,"country":87,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-14-009","Late Devonian and Early Carboniferous alpha diversity, ecospace occupation, vertebrate assemblages and bio-events of southeastern Morocco","Linda Frey","University of Zurich","CH",{"id":89,"funder":7,"programme":8,"title":90,"piName":91,"institution":92,"country":93,"year":13,"amount":14,"abstract":94},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vidi","A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis","Saiko Yoshida","Institute of Science and Technology Austria","AT","Multicellular development requires coordinated cell polarization relative to body axes, and translation to oriented cell division. In plants, it is unknown how cell polarities are connected to organismal axes and translated to division. Here, we identify Arabidopsis SOSEKI (SOK) proteins that integrate apical-basal and radial organismal axes to localize to polar cell edges. Localization does not depend on tissue context, requires cell wall integrity and is defined by a transferrable, protein-spe",{"id":96,"funder":7,"programme":8,"title":97,"piName":98,"institution":74,"country":12,"year":13,"amount":14,"abstract":99},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-vidi-189-005","Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding","Marvin E. Tanenbaum","Abstract mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous, as multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational heterogeneity, we developed the MoonTag, a new fluorescence labeling system to visualize translation of single mRNAs. When combined with the orthogonal SunTag system, the MoonTag enables dual readouts of translation, greatly expanding the possibilities to interrogate comple",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":104,"country":105,"year":13,"amount":14,"abstract":106},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-189-052","Modeling the short-term dynamics of \u003Ci>in vivo\u003C\u002Fi> excitatory spike transmission","Ian H. Stevenson","University of Connecticut","US","Abstract Information transmission in neural networks is influenced by both short-term synaptic plasticity (STP) as well as non-synaptic factors, such as after-hyperpolarization currents and changes in excitability. Although these effects have been widely characterized in vitro using intracellular recordings, how they interact in vivo is unclear. Here we develop a statistical model of the short-term dynamics of spike transmission that aims to disentangle the contributions of synaptic and non-syna",{"id":108,"funder":7,"programme":8,"title":109,"piName":110,"institution":111,"country":112,"year":13,"amount":14,"abstract":113},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-171-065","Global sea-level contribution from Arctic land ice: 1971–2017","Jason E. Box","Geological Survey of Denmark and Greenland","DK","The Arctic Monitoring and Assessment Program (AMAP 2017) report identifies the Arctic as the largest regional source of land ice to global sea-level rise in the 2003-2014 period. Yet, this contextualization ignores the longer perspective from in situ records of glacier mass balance. Here, using 17 (>55 N latitude) glacier and ice cap mass balance series in the 1971-2017 period, we develop a semi-empirical estimate of annual sea-level contribution from seven Arctic regions by scaling the in situ ",{"id":115,"funder":7,"programme":8,"title":116,"piName":117,"institution":118,"country":12,"year":13,"amount":14,"abstract":119},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-189-081","GimmeMotifs: an analysis framework for transcription factor motif analysis","Niklas Bruse","Radboud University Nijmegen","Abstract Background Transcription factors (TFs) bind to specific DNA sequences, TF motifs, in cis-regulatory sequences and control the expression of the diverse transcriptional programs encoded in the genome. The concerted action of TFs within the chromatin context enables precise temporal and spatial expression patterns. To understand how TFs control gene expression it is essential to model TF binding. TF motif information can help to interpret the exact role of individual regulatory elements, ",{"id":121,"funder":7,"programme":8,"title":122,"piName":123,"institution":124,"country":112,"year":13,"amount":14,"abstract":125},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-136-361","Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children","Anne‐Cathrine Finnemann Viuff","Aarhus University","Up to 13% of women may experience symptoms of depression during pregnancy or in the postpartum period. Depression during pregnancy has been associated with an increased risk of adverse neurodevelopmental outcomes in the child and epigenetic mechanisms could be one of the biological pathways to explain this association. In 844 mother-child pairs from the Avon Longitudinal Study of Parents and Children, we carried out an epigenome-wide association study (EWAS) to investigate associations between p",{"id":127,"funder":7,"programme":8,"title":128,"piName":129,"institution":80,"country":12,"year":13,"amount":14,"abstract":130},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-14126","Ideas and perspectives: Tree–atmosphere interaction responds to water-related stem variations","Tim van Emmerik","Abstract. Land–atmosphere interactions depend on momentum transfer from the atmosphere to the canopy, which in turn depends on the tree drag coefficient. It is known that the drag coefficient, and thus tree–atmosphere momentum transfer, can vary strongly within a canopy. Yet, only few measurements are available to study the variation of tree–atmosphere momentum transfer in time and space, and in response to tree water deficit. In this paper we use accelerometers to estimate tree–atmosphere momen",{"id":132,"funder":7,"programme":8,"title":133,"piName":134,"institution":135,"country":105,"year":13,"amount":14,"abstract":136},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-171-023","Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis","Fernando D. Camargo","Boston Children's Hospital","Mutation accumulation during life can contribute to hematopoietic dysfunction; however, the underlying dynamics are unknown. Somatic mutations in blood progenitors can provide insight into the rate and processes underlying this accumulation, as well as the developmental lineage tree and stem cell division numbers. Here, we catalog mutations in the genomes of human-bone-marrow-derived and umbilical-cord-blood-derived hematopoietic stem and progenitor cells (HSPCs). We find that mutations accumula",{"id":138,"funder":7,"programme":8,"title":139,"piName":140,"institution":118,"country":12,"year":13,"amount":14,"abstract":141},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-452-12-009","Structuring Time in Human Lateral Entorhinal Cortex","Jacob L.S. Bellmund","Abstract Remembering event sequences is central to episodic memory and thought to be supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a fixed route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that, after learning, multi-voxel representations in the anterior-lateral entorhinal cortex (alEC",{"id":143,"funder":7,"programme":8,"title":144,"piName":145,"institution":146,"country":105,"year":13,"amount":14,"abstract":147},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-917-10-364","Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo","Sabil Huda","Northwestern University","Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long \"flig",{"id":149,"funder":7,"programme":8,"title":150,"piName":151,"institution":38,"country":12,"year":13,"amount":14,"abstract":152},"openalex-nederlandse-organisatie-voor-wetenschapp-award-stw-vidi-13492","Distinct Signatures of Host Defense Suppression by Plant-Feeding Mites","Merijn R. Kant","Tomato plants are attacked by diverse herbivorous arthropods, including by cell-content-feeding mites, such as the extreme generalist \u003Ci>Tetranychus urticae\u003C\u002Fi> and specialists like \u003Ci>Tetranychus evansi\u003C\u002Fi> and \u003Ci>Aculops lycopersici\u003C\u002Fi>. Mite feeding induces plant defense responses that reduce mite performance. However, \u003Ci>T. evansi\u003C\u002Fi> and \u003Ci>A. lycopersici\u003C\u002Fi> suppress plant defenses via poorly understood mechanisms and, consequently, maintain a high performance on tomato. On a shared host, ",{"id":154,"funder":7,"programme":8,"title":155,"piName":156,"institution":157,"country":105,"year":13,"amount":14,"abstract":158},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-08-322","Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects","Scott Mackey","Media Working Group","The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.",{"id":160,"funder":7,"programme":8,"title":161,"piName":162,"institution":163,"country":12,"year":13,"amount":14,"abstract":164},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-ew-vidi-639-022-010","Enlarged perivascular spaces in brain MRI: Automated quantification in four regions","Florian Dubost","Erasmus MC","Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease. As such, assessing the burden of PVS has promise as a brain imaging marker. Visual and manual scoring of PVS is a tedious and observer-dependent task. Automated methods would advance research into the etiology of PVS, could aid to assess what a \"normal\" burden is in aging, and could evaluate the potential of PVS as a biomarker of c",{"id":166,"funder":7,"programme":8,"title":167,"piName":168,"institution":32,"country":12,"year":13,"amount":14,"abstract":169},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91716428","Physiological-based cord clamping in preterm infants using a new purpose-built resuscitation table: a feasibility study","Emma Brouwer","NTR6095, results.",{"id":171,"funder":7,"programme":8,"title":172,"piName":173,"institution":174,"country":57,"year":13,"amount":14,"abstract":175},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi","Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep","Thomas Schreiner","University of Birmingham","It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reoccur during subsequent sleep. We show that theta oscillations orchestrate the reactivation of memories during both wakefulness and sleep. Reactivation patterns during sleep autonomo",{"id":177,"funder":7,"programme":8,"title":172,"piName":173,"institution":174,"country":57,"year":13,"amount":14,"abstract":175},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-452-12-009-nwo-gravitation-024-001-006-nwo-magw-406-14-114-nwo-magw-406",{"id":179,"funder":7,"programme":8,"title":180,"piName":181,"institution":44,"country":12,"year":13,"amount":14,"abstract":182},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91716421","A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding","Constance C. F. M. J. Baaten","Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and heterogeneity in approaches or methodologies, a formal meta-analysis to compare studies of mice with single-gene defects encountered major limitations. To overcome these, we developed a n",{"id":184,"funder":7,"programme":8,"title":185,"piName":186,"institution":63,"country":12,"year":13,"amount":14,"abstract":187},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vidi-864-12-008","Local microtubule organization promotes cargo transport in \u003Ci>C. elegans\u003C\u002Fi> dendrites","Martin Harterink","The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal polarity that allows for selective cargo sorting. However, how dendritic microtubules are organized and whether local differences influence cargo transport remains largely unknown. Here, we use live-cell imaging to systematically probe the microtubule organization in \u003Ci>Caenorhabditis\u003C\u002Fi>\u003Ci>elegans\u003C\u002Fi> neurons, and demonstrate the contribution of distin",{"id":189,"funder":7,"programme":8,"title":190,"piName":191,"institution":192,"country":193,"year":13,"amount":14,"abstract":194},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-178-014","Influence of Arm Swing on Cost of Transport during Walking","Sjoerd M. Bruijn","Fujian Medical University","CN","ABSTRACT Normal arm swing plays a role in decreasing the cost of transport during walking. However, whether excessive arm swing can reduce the cost of transport even further is unknown. Therefore, we tested the effects of normal and exaggerated arm swing on the cost of transport in the current study. Healthy participants ( n =12) walked on a treadmill (1.25 m\u002Fs) in seven trials with different arm swing amplitudes (in-phase, passive restricted, active restricted, normal, three gradations of extra",{"id":196,"funder":7,"programme":8,"title":197,"piName":198,"institution":199,"country":12,"year":13,"amount":14,"abstract":200},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-639-042-525","Modelling the disc atmosphere of the low mass X-ray binary EXO 0748-676","I. Psaradaki","SRON Netherlands Institute for Space Research","Low mass X-ray binaries exhibit ionized emission from an extended disc atmosphere that surrounds the accretion disc. However, the atmosphere’s nature and geometry is still unclear. In this work we present a spectral analysis of the extended atmosphere of EXO 0748-676 using high-resolution spectra from archival XMM-Newton observations. We model the spectrum that is obtained during the eclipses. This enables us to model the emission lines that come only from the extended atmosphere of the source, ",{"id":202,"funder":7,"programme":8,"title":203,"piName":204,"institution":118,"country":12,"year":13,"amount":14,"abstract":205},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-12-003","Disentangling common from specific processing across tasks using task potency","Roselyne J. Chauvin","When an individual engages in a task, the associated evoked activities build upon already ongoing activity, shaped by an underlying functional connectivity baseline (Fox et al., 2009; Smith et al., 2009; Tavor et al., 2016). Building on the idea that rest represents the brain's full functional repertoire, we here incorporate the idea that task-induced functional connectivity modulations ought to be task-specific with respect to their underlying resting state functional connectivity. Various metr",{"id":207,"funder":7,"programme":8,"title":203,"piName":204,"institution":118,"country":12,"year":13,"amount":14,"abstract":205},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-12",{"id":209,"funder":7,"programme":8,"title":210,"piName":211,"institution":118,"country":12,"year":13,"amount":14,"abstract":212},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-12-007","Quantitative subcellular proteomics using SILAC reveals enhanced metabolic buffering in the pluripotent ground state","Hendrik Marks","The ground state of pluripotency is defined as a minimal unrestricted epigenetic state as present in the Inner Cell Mass. Mouse embryonic stem cells (ESCs) grown in a defined serum-free medium with two kinase inhibitors (\"2i ESCs\") have been postulated to reflect ground-state pluripotency, whereas ESCs grown in the presence of serum (\"serum ESCs\") share more similarities with post-implantation epiblast cells. Pluripotency results from an intricate interplay between cytoplasmic, nuclear and chrom",{"id":214,"funder":7,"programme":8,"title":215,"piName":216,"institution":50,"country":12,"year":13,"amount":14,"abstract":217},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-144312","Reply to ‘Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission’","Alberto Acerbi","In the Smaldino et al. study 'Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission', our original findings regarding the conditional validity of using population-level sigmoidal acquisition curves as means to evidence individual-level conformity are contested. We acknowledge the identification of useful nuances, yet conclude that our original findings remain relevant for the study of conformist learning mechanisms.Replying to: Smaldino, P. E., Aplin, L. M. & Farine, D. R. ",{"id":219,"funder":7,"programme":8,"title":220,"piName":221,"institution":222,"country":57,"year":13,"amount":14,"abstract":223},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-161-324","A first collective validation of global fluvial flood models for major floods in Nigeria and Mozambique","Mark Bernhofen","University of Leeds","Global flood models (GFMs) are becoming increasingly important for disaster risk management internationally. However, these models have had little validation against observed flood events, making it difficult to compare model performance. In this paper, we introduce the first collective validation of multiple GFMs against the same events and we analyse how different model structures influence performance. We identify three hydraulically diverse regions in Africa with recent large scale flood eve",{"id":225,"funder":7,"programme":8,"title":226,"piName":227,"institution":228,"country":12,"year":13,"amount":14,"abstract":229},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-917-13334","TPX2\u002FAurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells","Stephanie E. van Gijn","University Medical Center Groningen","Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests that cancer cells are molecularly \"rewired\" to cope with defective DNA repair and the resulting high levels of genomic instability. In this study, we aim to identify genes that gen",{"id":231,"funder":7,"programme":8,"title":232,"piName":233,"institution":234,"country":235,"year":13,"amount":14,"abstract":236},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-15707","Impact of Chemical Fluctuations on Stacking Fault Energies of CrCoNi and CrMnFeCoNi High Entropy Alloys from First Principles","Yuji Ikeda","Kyoto University","JP","Medium and high entropy alloys (MEAs and HEAs) based on 3d transition metals, such as face-centered cubic (fcc) CrCoNi and CrMnFeCoNi alloys, reveal remarkable mechanical properties. The stacking fault energy (SFE) is one of the key ingredients that controls the underlying deformation mechanism and hence the mechanical performance of materials. Previous experiments and simulations have therefore been devoted to determining the SFEs of various MEAs and HEAs. The impact of local chemical environme",{"id":238,"funder":7,"programme":8,"title":239,"piName":240,"institution":241,"country":57,"year":13,"amount":14,"abstract":242},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-10-012","Weak breeding seasonality of a songbird in a seasonally arid tropical environment arises from individual flexibility and strongly seasonal moult","Chima J. Nwaogu","University of St Andrews","In some tropical birds, breeding seasonality is weak at the population level, even where there are predictable seasonal peaks in environmental conditions. It therefore remains unclear whether individuals are adapted to breeding at specific times of the year or flexible to variable environmental conditions. We tested whether the relative year‐round breeding activity of the Common Bulbul Pycnonotus barbatus arises due to within‐individual variability in breeding dates. We collected data from 827 b",{"id":244,"funder":7,"programme":8,"title":245,"piName":246,"institution":80,"country":12,"year":13,"amount":14,"abstract":247},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant","The Conversation Continues: the Effect of Lyrics and Music Complexity of Background Music on Spoken-Word Recognition","Odette Scharenborg","<p>Background music in social interaction settings can hinder conversation. Yet, little is known of how specific properties of music impact speech processing. This paper addresses this knowledge gap by investigating the effect of the 1) complexity of the background music, and 2) the presence versus absence of sung lyrics on spoken-word recognition in background music. To answer these questions, a word identification experiment was run in which Dutch participants listened to Dutch CVC words",{"id":249,"funder":7,"programme":8,"title":250,"piName":251,"institution":252,"country":253,"year":13,"amount":14,"abstract":254},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-917-96-318","Re-inforcing the cell death army in the fight against breast cancer","Clara Oudenaarden","Lund University","SE","Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused by the absence of cellular adhesion, a process that underpins lumen formation and maintenance during mammary gland development and homeostasis. In healthy cells, anoikis is mostly governed by B-cell lymphoma-2 (BCL2) protein family members. Metastatic cancer cells, however, have often deve",{"id":256,"funder":7,"programme":8,"title":257,"piName":258,"institution":259,"country":260,"year":13,"amount":14,"abstract":261},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-11-009","Shallow S‐Wave Velocity Structure from Ambient Seismic Noise at Planchón‐Peteroa Volcanic Complex, Argentina‐ChileShallow S‐Wave Velocity Structure from Ambient Seismic Noise at Planchón‐Peteroa","José Augusto Casas","Consejo Nacional de Investigaciones Científicas y Técnicas","AR","We applied the seismic interferometry technique to characterize the subsurface velocities of the Planchón-Peteroa Volcanic Complex, Argentina-Chile, down to a depth of about 350 m. Ambient seismic noise data were recorded by an array of six stations deployed in the eastern flank of the current active volcano of this volcanic complex—the Peteroa. To ensure retrieval of accurate surface-wave Green’s functions, we analyzed the directivity of the recorded ambient noise and then selected the noise wi",{"id":263,"funder":7,"programme":8,"title":264,"piName":265,"institution":80,"country":12,"year":13,"amount":14,"abstract":266},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-14-004","The Evolution of the Systems of Cities Literature Since 1995: Schools of Thought and their Interaction","Antoine Peris","The study of relations between cities has long been a major focus in urban research. For decades, this field has grown integrating contributions from many disciplines. But today, the field appears rather fragmented. This study analyses the body of literature that has developed over the last 23 years to identify schools of thought on interurban relationships and to see to what extent these interact with each other. It does so by innovatively employing bibliometric analysis to the study of systems",{"id":268,"funder":7,"programme":8,"title":269,"piName":270,"institution":32,"country":12,"year":13,"amount":14,"abstract":271},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-knibbe-2013-","Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach","Janneke M. Brussee","In conclusion, the intrinsic CYP3A-mediated gut wall clearance is substantially lower than the intrinsic hepatic CYP3A-mediated clearance in children from 1 to 18 years of age, and contributes less to the overall first-pass metabolism compared to adults.",{"id":273,"funder":7,"programme":8,"title":274,"piName":275,"institution":276,"country":12,"year":13,"amount":14,"abstract":277},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-639-072-411","A robust deconvolution method to disentangle multiple water pools in diffusion MRI","Alberto De Luca","University of Applied Sciences Utrecht","The diffusion-weighted magnetic resonance imaging (dMRI) signal measured in vivo arises from multiple diffusion domains, including hindered and restricted water pools, free water and blood pseudo-diffusion. Not accounting for the correct number of components can bias metrics obtained from model fitting because of partial volume effects that are present in, for instance, diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI). Approaches that aim to overcome this shortcoming generally",{"id":279,"funder":7,"programme":8,"title":280,"piName":281,"institution":282,"country":12,"year":13,"amount":14,"abstract":283},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-171011","The influence of Arctic amplification on mid-latitude summer circulation","Dim Coumou","Vrije Universiteit Amsterdam","Accelerated warming in the Arctic, as compared to the rest of the globe, might have profound impacts on mid-latitude weather. Most studies analyzing Arctic links to mid-latitude weather focused on winter, yet recent summers have seen strong reductions in sea-ice extent and snow cover, a weakened equator-to-pole thermal gradient and associated weakening of the mid-latitude circulation. We review the scientific evidence behind three leading hypotheses on the influence of Arctic changes on mid-lati",{"id":285,"funder":7,"programme":8,"title":280,"piName":281,"institution":282,"country":12,"year":13,"amount":14,"abstract":283},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-171-011",{"id":287,"funder":7,"programme":8,"title":288,"piName":289,"institution":38,"country":12,"year":13,"amount":14,"abstract":290},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-10-018","No Evidence That Baseline Prefrontal Cortical Excitability (3T-MRS) Predicts the Effects of Prefrontal tDCS on WM Performance","Lotte J. Talsma","Transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) is a promising tool to enhance working memory (WM) in clinical as well as healthy populations. Yet, tDCS does not affect everyone similarly: whereas tDCS improves WM in most individuals, some individuals do not, or actually show detriments in WM performance after stimulation. One hypothesis that has been put forward to account for individual differences in tDCS response is that baseline cortical ",{"id":292,"funder":7,"programme":8,"title":293,"piName":294,"institution":44,"country":12,"year":13,"amount":14,"abstract":295},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-452-16-004","Atypical White Matter Connectivity in Dyslexic Readers of a Fairly Transparent Orthography","Gojko Žarić","Atypical structural properties of the brain's white matter bundles have been associated with failing reading acquisition in developmental dyslexia. Because these white matter properties may show dynamic changes with age and orthographic depth, we examined fractional anisotropy (FA) along 16 white matter tracts in 8- to 11-year-old dyslexic (DR) and typically reading (TR) children learning to read in a fairly transparent orthography (Dutch). Our results showed higher FA values in the bilateral an",{"id":297,"funder":7,"programme":8,"title":298,"piName":299,"institution":118,"country":12,"year":13,"amount":14,"abstract":300},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-12-009","Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development","Leonie M. Kamminga","Polycomb Group (PcG) genes are transcriptional repressors that are described to be important during development and differentiation. There is significant interest in PcGs proteins because of their role in stem cell biology and tumorigenesis. In this study we characterize the expression of a selection of PcG genes in the adult germline of zebrafish and during embryogenesis. In adults, expression of selected PcG genes is found to be enriched in germ line over somatic tissues. Therefore, the germ l",{"id":302,"funder":7,"programme":8,"title":298,"piName":299,"institution":118,"country":12,"year":13,"amount":14,"abstract":300},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-12-009",{"id":304,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-016",{"id":306,"funder":7,"programme":8,"title":307,"piName":308,"institution":309,"country":57,"year":13,"amount":14,"abstract":310},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-no-15707","Temperature dependence of the Gibbs energy of vacancy formation of fcc Ni","Yilun Gong","University of Oxford","Quantum-mechanical calculations are used to determine the temperature dependence of the Gibbs energy of vacancy formation in nickel. Existing data reveal a discrepancy between the high-temperature estimates from experiments and low-temperature approximations from density functional theory. Our finite-temperature calculations---which include the effects of magnetism and fully interacting phonon vibrations---demonstrate that this discrepancy is mostly caused by the previously neglected explicit an",{"id":312,"funder":7,"programme":8,"title":313,"piName":314,"institution":38,"country":12,"year":13,"amount":14,"abstract":315},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-no-680-47-554-3259","Universal disorder-induced broadening of phonon bands: from disordered lattices to glasses","Edan Lerner","The translational symmetry of solids, either ordered or disordered, gives rise to the existence of low-frequency phonons. In ordered systems, either crystalline solids or isotropic homogeneous continua, some phonons characterized by different wavevectors are degenerate, i.e. they share the exact same frequency ω; in finite-size systems, phonons form a discrete set of bands with nq(ω)-fold degeneracy. Here we focus on understanding how this degeneracy is lifted in the presence of disorder, and it",{"id":317,"funder":7,"programme":8,"title":318,"piName":319,"institution":74,"country":12,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-project-917-16-430","Outlier classification performance of risk adjustment methods when profiling multiple providers","Timo B. Brakenhoff","Of the evaluated PS methods, only PS adjustment can be considered a viable alternative to random effects logistic regression when profiling multiple providers in different scenarios.",{"id":322,"funder":7,"programme":8,"title":318,"piName":319,"institution":74,"country":12,"year":13,"amount":14,"abstract":320},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-project-917-16-430",{"id":324,"funder":7,"programme":8,"title":325,"piName":326,"institution":63,"country":12,"year":13,"amount":14,"abstract":327},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-vidi-171-006","A stress recovery signaling network for enhanced flooding tolerance in \u003Ci>Arabidopsis thaliana\u003C\u002Fi>","Elaine Yeung","Abiotic stresses in plants are often transient, and the recovery phase following stress removal is critical. Flooding, a major abiotic stress that negatively impacts plant biodiversity and agriculture, is a sequential stress where tolerance is strongly dependent on viability underwater and during the postflooding period. Here we show that in \u003Ci>Arabidopsis thaliana\u003C\u002Fi> accessions (Bay-0 and Lp2-6), different rates of submergence recovery correlate with submergence tolerance and fecundity. A geno",{"id":329,"funder":7,"programme":8,"title":330,"piName":331,"institution":332,"country":333,"year":13,"amount":14,"abstract":334},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-276-20-013","An introduction to real possibilities, indeterminism, and free will: three contingencies of the debate","Thomas Müller","University of Konstanz","DE","The papers collected in this Special Issue document the development of a novel, positive understanding of indeterminism grounded in real possibilities, and the interrelation of that development with the free will debate.",{"id":336,"funder":7,"programme":8,"title":337,"piName":338,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-11-002","Ultra-high resolution blood volume fMRI and BOLD fMRI in humans at 9.4 T: Capabilities and challenges","Laurentius Huber",{"id":340,"funder":7,"programme":8,"title":341,"piName":342,"institution":26,"country":12,"year":13,"amount":14,"abstract":343},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-09-016","Glucocorticoid‐mediated modulation of morphological changes associated with aging in microglia","Marijn Schouten","Microglia dynamically adapt their morphology and function during increasing age. However, the mechanisms behind these changes are to date poorly understood. Glucocorticoids (GCs) are long known and utilized for their immunomodulatory actions and endogenous GC levels are described to alter with advancing age. We here tested the hypothesis that age-associated elevations in GC levels implicate microglia function and morphology. Our data indicate a decrease in microglial complexity and a concomitant",{"id":345,"funder":7,"programme":8,"title":346,"piName":347,"institution":348,"country":349,"year":13,"amount":14,"abstract":350},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-11-349","Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α2-adrenoceptors and 5-HT1 receptors","Abimael González‐Hernández","Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional","MX","DHE-induced inhibition of the vasodepressor sensory CGRPergic outflow is mainly mediated by prejunctional rauwolscine-sensitive α\u003Csub>2\u003C\u002Fsub>-adrenoceptors and GR127935-sensitive 5-HT\u003Csub>1B\u002F1D\u003C\u002Fsub> receptors, which correlate with α\u003Csub>2A\u002F2C\u003C\u002Fsub>-adrenoceptors and 5-HT\u003Csub>1B\u003C\u002Fsub> receptors, respectively. These findings suggest that DHE-induced inhibition of the perivascular sensory CGRPergic outflow may facilitate DHE's vasoconstrictor properties resulting in an increased vascular resistanc",{"id":352,"funder":7,"programme":8,"title":353,"piName":354,"institution":63,"country":12,"year":13,"amount":14,"abstract":355},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vidi-171-029","Functional organization of postsynaptic glutamate receptors","Harold D. MacGillavry","Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the brain, responsible for mediating the vast majority of excitatory transmission in neuronal networks. The AMPA- and NMDA-type ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the fast synaptic responses, while metabotropic glutamate receptors (mGluRs) are coupled to downstream signaling cascades that act on much slower timescales. These functionally distinct receptor sub-types a",{"id":357,"funder":7,"programme":8,"title":358,"piName":359,"institution":360,"country":361,"year":13,"amount":14,"abstract":362},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-723-012-106","About Chemical Strategies to Fabricate Cell‐Instructive Biointerfaces with Static and Dynamic Complexity","Pascal Jonkheijm","University of Toronto","CA","Properly functioning cell-instructive biointerfaces are critical for healthy integration of biomedical devices in the body and serve as decisive tools for the advancement of our understanding of fundamental cell biological phenomena. Studies are reviewed that use covalent chemistries to fabricate cell-instructive biointerfaces. These types of biointerfaces typically result in a static presentation of predefined cell-instructive cues. Chemically defined, but dynamic cell-instructive biointerfaces",{"id":364,"funder":7,"programme":8,"title":365,"piName":366,"institution":32,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-13-010","Acute sensitivity of three Cladoceran species to different types of microplastics in combination with thermal stress","Thijs Bosker",{"id":368,"funder":7,"programme":8,"title":369,"piName":370,"institution":371,"country":372,"year":13,"amount":14,"abstract":373},"openalex-nederlandse-organisatie-voor-wetenschapp-award-id-452-17-002","Pain as a threat to the social self: a motivational account","Kai Karos","KU Leuven","BE","sponsorship: K. Karos is a doctoral researcher supported by the Research Foundation, Flanders, Belgium (grant 1111015N). A. Meulders is a postdoctoral researcher of the Research Foundation Flanders (FWO-Vlaanderen), Belgium (grant ID 12E3717N), and is supported by a Vidi grant from the Netherlands Organization for Scientific Research (NWO), the Netherlands (grant ID 452-17-002). (Research Foundation, Flanders, Belgium|1111015N, Research Foundation Flanders (FWO-Vlaanderen), Belgium|12E3717N, Vid",{"id":375,"funder":7,"programme":8,"title":369,"piName":370,"institution":371,"country":372,"year":13,"amount":14,"abstract":373},"openalex-nederlandse-organisatie-voor-wetenschapp-award--nwo-",{"id":377,"funder":7,"programme":8,"title":369,"piName":370,"institution":371,"country":372,"year":13,"amount":14,"abstract":373},"openalex-nederlandse-organisatie-voor-wetenschapp-award-452-17-002",{"id":379,"funder":7,"programme":8,"title":380,"piName":381,"institution":38,"country":12,"year":13,"amount":14,"abstract":382},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-145-369","Combined Forces: Thinking and\u002For Feeling? How News Consumption Affects Anti-Muslim Attitudes through Perceptions and Emotions about the Economy","Laura Jacobs","This study develops a model that contributes to our understanding of the complex relationship between economic motivations and anti-Muslim attitudes by analyzing the underexplored role of news consumption. Using a large-scale Dutch panel dataset ( n = 2694), we test a structural equation model theoretically grounded in group conflict theory, in which the relationship between news consumption and anti-Muslim attitudes is mediated by perceptions and emotions about the economy. Findings offer sound",{"id":384,"funder":7,"programme":8,"title":385,"piName":386,"institution":80,"country":12,"year":13,"amount":14,"abstract":387},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-project-number-723-012-","Self-replication of DNA by its encoded proteins in liposome-based synthetic cells","Pauline van Nies","Replication of DNA-encoded information and its conversion into functional proteins are universal properties of life. In an effort toward the construction of a synthetic minimal cell, we implement here the DNA replication machinery of the Φ29 virus in a cell-free gene expression system. Amplification of a linear DNA template by self-encoded, de novo synthesized Φ29 proteins is demonstrated. Complete information transfer is confirmed as the copied DNA can serve as a functional template for gene ex",{"id":389,"funder":7,"programme":8,"title":390,"piName":391,"institution":392,"country":12,"year":13,"amount":14,"abstract":393},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vidi-grant-864-09-007","The Cultural Importance of Plants in Western African Religions","Tinde van Andel","Naturalis Biodiversity Center","This paper explores the importance of elements of the natural world, and particularly plants, among people of different religious affiliations in western Africa\u003Ci>.\u003C\u002Fi> Plants play an overriding role in African folk religions, which in turn are closely associated with health practices and influence management decisions concerning natural resources. In spite of the extensive literature documenting ritual plant use, the cultural importance of plants in this context has not been systematically asse",{"id":395,"funder":7,"programme":8,"title":396,"piName":397,"institution":398,"country":333,"year":13,"amount":14,"abstract":399},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-13-009","An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential","Joachim M. Matz","Humboldt-Universität zu Berlin","Proteins of the stomatin\u002Fprohibitin\u002Fflotillin\u002FHfIK\u002FC (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles. Here, we investigate the SPFH proteins of the murine malaria model parasite Plasmodium berghei, the conserved prohibitin 1, prohibitin 2, and stomatin-like protein and an unusual prohibitin-like protein (PHBL). The SPFH proteins localize to the parasite mitochondrion. While the conserved family members could not be deleted from the Plasmodium ge",{"id":401,"funder":7,"programme":8,"title":396,"piName":397,"institution":398,"country":333,"year":13,"amount":14,"abstract":399},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-13-009",{"id":403,"funder":7,"programme":8,"title":404,"piName":405,"institution":228,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-164-455","Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs","LifeLines Cohort Study",{"id":407,"funder":7,"programme":8,"title":404,"piName":405,"institution":228,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-vidi-917-14-374",{"id":409,"funder":7,"programme":8,"title":410,"piName":411,"institution":412,"country":12,"year":13,"amount":14,"abstract":413},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-452-16-012","Obtaining insights from high-dimensional data: sparse principal covariates regression","Katrijn Van Deun","Tilburg University","The source code implementing our proposed method is available from GitHub, together with all scripts used to extract, pre-process, analyze, and post-process the data: https:\u002F\u002Fgithub.com\u002Fkatrijnvandeun\u002FSPCovR .",{"id":415,"funder":7,"programme":8,"title":416,"piName":417,"institution":63,"country":12,"year":13,"amount":14,"abstract":418},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-12-003","Soil salinity inhibits plant shade avoidance","Ronald Pierik","Summary Global food production is set to keep increasing despite a predicted decrease in total arable land [1]. To achieve higher production, denser planting will be required on increasingly degraded soils. When grown in dense stands, crops elongate and raise their leaves in an effort to reach sunlight, a process termed shade-avoidance [2]. Shade is perceived by a reduction in the ratio of red (R) to (FR) light and results in the stabilisation of a class of transcription factors known as PHYTOCH",{"id":420,"funder":7,"programme":8,"title":421,"piName":422,"institution":423,"country":12,"year":13,"amount":14,"abstract":424},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-knibbe","The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models","Catherijne A. J. Knibbe","St. Antonius Ziekenhuis","In covariate (sub)models of population pharmacokinetic models, most covariates are normalized to the median value; however, for body weight, normalization to 70 kg or 1 kg is often applied. In this article, we illustrate the impact of normalization weight on the precision of population clearance (CL\u003Csub>pop\u003C\u002Fsub>) parameter estimates. The influence of normalization weight (70, 1 kg or median weight) on the precision of the CL\u003Csub>pop\u003C\u002Fsub> estimate, expressed as relative standard error (RSE), wa",{"id":426,"funder":7,"programme":8,"title":427,"piName":428,"institution":429,"country":12,"year":13,"amount":14,"abstract":430},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-10-008","Effects of admixture in native and invasive populations of Lythrum salicaria","Koen J. F. Verhoeven","Netherlands Institute of Ecology","Intraspecific hybridization between diverged populations can enhance fitness via various genetic mechanisms. The benefits of such admixture have been proposed to be particularly relevant in biological invasions, when invasive populations originating from different source populations are found sympatrically. However, it remains poorly understood if admixture is an important contributor to plant invasive success and how admixture effects compare between invasive and native ranges. Here, we used ex",{"id":432,"funder":7,"programme":8,"title":433,"piName":434,"institution":435,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-438730","Local and global analysis of endocrine regulation as a non-cyclic feedback system","Hadi Taghvafard","University of Groningen",{"id":437,"funder":7,"programme":8,"title":438,"piName":439,"institution":440,"country":105,"year":13,"amount":14,"abstract":441},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-grant-no-016-161-324-","Identification of symmetric and asymmetric responses in seasonal streamflow globally to ENSO phase","Paul Block","University of Wisconsin–Madison","The phase of the El Niño Southern Oscillation (ENSO) has large-ranging effects on streamflow and hydrologic conditions globally. While many studies have evaluated this relationship through correlation analysis between annual streamflow and ENSO indices, an assessment of potential asymmetric relationships between ENSO and streamflow is lacking. Here, we evaluate seasonal variations in streamflow by ENSO phase to identify asymmetric (AR) and symmetric (SR) spatial pattern responses globally and fu",{"id":443,"funder":7,"programme":8,"title":444,"piName":445,"institution":32,"country":12,"year":13,"amount":14,"abstract":446},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-91711319","Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling","Marek Noga","Most amines can be considered stable during sampling, provided that samples are cooled immediately to 4 °C, centrifuged, and stored at - 80 °C within 2 h. The effect of ethanol addition for more unstable metabolites needs further investigation. This was the first time that labeled compounds were used to monitor ex vivo metabolism during sampling. This is a useful strategy to study the stability of other metabolites of interest.",{"id":448,"funder":7,"programme":8,"title":449,"piName":450,"institution":451,"country":452,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-13-013","Environment dominates over host genetics in shaping human gut microbiota","Daphna Rothschild","Weizmann Institute of Science","IL",{"id":454,"funder":7,"programme":8,"title":455,"piName":456,"institution":435,"country":12,"year":13,"amount":14,"abstract":457},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-276-80-004","Interacting with Fictions: The Role of Pretend Play in Theory of Mind Acquisition","Merel Semeijn","Pretend play is generally considered to be a developmental landmark in Theory of Mind acquisition. The aim of the present paper is to offer a new account of the role of pretend play in Theory of Mind development. To this end I combine Hutto and Gallagher’s account of social cognition development with Matravers’ recent argument that the cognitive processes involved in engagement with narratives are neutral regarding fictionality. The key contribution of my account is an analysis of pretend play a",{"id":459,"funder":7,"programme":8,"title":460,"piName":461,"institution":63,"country":12,"year":13,"amount":14,"abstract":462},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-13339-petridou-","Maximizing sensitivity for fast GABA edited spectroscopy in the visual cortex at 7 T","Arjan D. Hendriks","The combination of functional MRI (fMRI) and MRS is a promising approach to relate BOLD imaging to neuronal metabolism, especially at high field strength. However, typical scan times for GABA edited spectroscopy are of the order of 6-30 min, which is long compared with functional changes observed with fMRI. The aim of this study is to reduce scan time and increase GABA sensitivity for edited spectroscopy in the human visual cortex, by enlarging the volume of activated tissue in the primary visua",{"id":464,"funder":7,"programme":8,"title":465,"piName":466,"institution":467,"country":468,"year":13,"amount":14,"abstract":469},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-14-004-","Metagenomic Characterization of the Human Intestinal Microbiota in Fecal Samples from STEC-Infected Patients","Federica Gigliucci","Roma Tre University","IT","The human intestinal microbiota is a homeostatic ecosystem with a remarkable impact on human health and the disruption of this equilibrium leads to an increased susceptibility to infection by numerous pathogens. In this study, we used shotgun metagenomic sequencing and two different bioinformatic approaches, based on mapping of the reads onto databases and on the reconstruction of putative draft genomes, to investigate possible changes in the composition of the intestinal microbiota in samples f",{"id":471,"funder":7,"programme":8,"title":472,"piName":473,"institution":118,"country":12,"year":13,"amount":14,"abstract":474},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-11-339","Determinants of selective reporting: A taxonomy based on content analysis of a random selection of the literature","Jenny T. van der Steen","We designed a taxonomy of putative determinants of selective reporting consisting of 12 categories. The taxonomy may help develop theory about causes of selection bias and guide policies to prevent selective reporting.",{"id":476,"funder":7,"programme":8,"title":477,"piName":478,"institution":479,"country":12,"year":13,"amount":14,"abstract":480},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-146-353","Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease","Kerstin Schneeberger","Wilhelmina Children's Hospital","The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of nutrients. The establishment of cell polarity requires a specialized subcellular machinery to transport and recycle proteins to their appropriate location. In order to understand and treat polarity-associated diseases, it is necessary to understand ep",{"id":482,"funder":7,"programme":8,"title":483,"piName":484,"institution":14,"country":14,"year":13,"amount":14,"abstract":485},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-178-047","An auditory dataset of passing vehicles recorded with a smartphone","Pavlo Bazilinskyy",".mp4 files and .wav files corresponding to the paper 'An auditory dataset of passing vehicles recorded with a smartphone' Also included is a MATLAB m-file that produces the figures in the paper.",{"id":487,"funder":7,"programme":8,"title":483,"piName":484,"institution":14,"country":14,"year":13,"amount":14,"abstract":485},"openalex-nederlandse-organisatie-voor-wetenschapp-award-ttw-016-vidi-178-047",{"id":489,"funder":7,"programme":8,"title":490,"piName":491,"institution":63,"country":12,"year":13,"amount":14,"abstract":492},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-13339","Detailed T1-Weighted Profiles from the Human Cortex Measured in Vivo at 3 Tesla MRI","B. Ferguson","Studies into cortical thickness in psychiatric diseases based on T1-weighted MRI frequently report on aberrations in the cerebral cortex. Due to limitations in image resolution for studies conducted at conventional MRI field strengths (e.g. 3 Tesla (T)) this information cannot be used to establish which of the cortical layers may be implicated. Here we propose a new analysis method that computes one high-resolution average cortical profile per brain region extracting myeloarchitectural informati",{"id":494,"funder":7,"programme":8,"title":495,"piName":496,"institution":50,"country":12,"year":13,"amount":14,"abstract":497},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-014-006","Light induced assembly and self-sorting of silica microparticles","Ilja K. Voets","To tailor the properties of colloidal materials, precise control over the self-assembly of their constituents is a prerequisite. Here, we govern the assembly of silica particles by functionalization with supramolecular moieties which interact with each other via directional and reversible hydrogen bonding. Through a generally applicable synthesis protocol, two different types of self-complementary hydrogen bonding moieties, BTA- and UPy-derivatives, are anchored to silica particles. Their self-a",{"id":499,"funder":7,"programme":8,"title":495,"piName":496,"institution":50,"country":12,"year":13,"amount":14,"abstract":497},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-723-014-006",{"id":501,"funder":7,"programme":8,"title":502,"piName":503,"institution":50,"country":12,"year":13,"amount":14,"abstract":504},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-680-47-530","All-Optical Imaging of Gold Nanoparticle Geometry Using Super-Resolution Microscopy","Adam B. Taylor","We demonstrate the all-optical reconstruction of gold nanoparticle geometry using super-resolution microscopy. We employ DNA-PAINT to get exquisite control over the (un)binding kinetics by the number of complementary bases and salt concentration, leading to localization accuracies of ∼5 nm. We employ a dye with an emission spectrum strongly blue-shifted from the plasmon resonance to minimize mislocalization due to plasmon-fluorophore coupling. We correlate the all-optical reconstructions with at",{"id":506,"funder":7,"programme":8,"title":507,"piName":508,"institution":435,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-talent-scheme-vidi-with-project-number-723-015-005","Complete lignocellulose conversion with integrated catalyst recycling yielding valuable aromatics and fuels","Zhuohua Sun",{"id":510,"funder":7,"programme":8,"title":511,"piName":512,"institution":435,"country":12,"year":13,"amount":14,"abstract":513},"openalex-nederlandse-organisatie-voor-wetenschapp-award-talent-scheme-vidi-with-project-number-723-015-0","Efficient nickel-catalysed\u003Ci>N\u003C\u002Fi>-alkylation of amines with alcohols","Katalin Barta","A highly active and easy-to-prepare Ni based catalyst system is presented for the selective\u003Citalic>N\u003C\u002Fitalic>-alkylation of amines with alcohols that is\u003Citalic>in situ\u003C\u002Fitalic>generated from Ni(COD)\u003Csub>2\u003C\u002Fsub>and KOH under ligand-free conditions.",{"id":515,"funder":7,"programme":8,"title":516,"piName":517,"institution":63,"country":12,"year":13,"amount":14,"abstract":518},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-13457-and-nwo-aspasia-015-009-038","Polymers and hydrogels for local nucleic acid delivery","Tina Vermonden","The potential of gene therapy for the treatment for chronic and life-threatening diseases has been seen for a long time, but widespread applications are still hampered by the difficulties to deliver the highly charged and large nucleic acid molecules to their intracellular targets. More recently, investigators have been aiming for local delivery of nucleic acids mostly by the use of hydrogels. In this way, in vivo efficacy can be enhanced by avoiding the target transport challenges and at the sa",{"id":520,"funder":7,"programme":8,"title":516,"piName":517,"institution":63,"country":12,"year":13,"amount":14,"abstract":518},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-13457",{"id":522,"funder":7,"programme":8,"title":523,"piName":524,"institution":44,"country":12,"year":13,"amount":14,"abstract":525},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-176-340","Mechano-Chemical Interactions in the Isotonic Twitch: A Modeling Study","Lauren J. Dupuis","Tension development in the cardiac sarcomere is highly cooperative, yet the mechanism is not known. We have developed the MechChem model of sarcomere mechanics, which incorporates a mechano-chemical interaction-based cooperativity mechanism in which the thin filament has an intrinsic chemical cooperativity that is boosted by mechanical tension in the thin filament.. In the current study, we extend the MechChem model to include the possibility for the sarcomere to change length when contracting a",{"id":527,"funder":7,"programme":8,"title":528,"piName":529,"institution":20,"country":12,"year":13,"amount":14,"abstract":530},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-13-001","Control of cell division orientation during vascular development in Arabidopsis thaliana","Wouter Smet","Growth of plants depends on cell division and elongation of the divided cells. After cell division, plant cells are fixed immediately within their tissue context. Thus, a carefully positioning and orientation of the division plane is crucial for plants to properly pattern and grow. Anticlinal cell divisions result in more cells within a cell file and lead to longitudinal growth; while periclinal and radial divisions (PRD) result in the addition of cell files during radial growth. So far, how a c",{"id":532,"funder":7,"programme":8,"title":533,"piName":534,"institution":535,"country":333,"year":13,"amount":14,"abstract":536},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-014-010","The Importance of Chemical Reactions in the Charging Process of Lithium-Sulfur Batteries","Anne Berger","Technical University of Munich","The underlying mechanism of lithium-sulfur batteries is still not fully established because it involves a series of both chemical and electrochemical reactions as well as the formation of soluble polysulfide intermediates. To improve the mechanistic understanding of lithium-sulfur batteries, this study investigates chemical reactions between the Li2S cathode and more oxidized sulfur species, such as S8 and polysulfides, during the electrochemical charge of the battery. By combining the electroch",{"id":538,"funder":7,"programme":8,"title":539,"piName":540,"institution":435,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-91713334","Replication stress: Driver and therapeutic target in genomically instable cancers","Marcel A.T.M. van Vugt",{"id":542,"funder":7,"programme":8,"title":543,"piName":544,"institution":545,"country":12,"year":13,"amount":14,"abstract":546},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-14-001","The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation","Maksim V. Baranov","Radboud Institute for Molecular Life Sciences","Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo\u002Fphagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by small molecule inhibitors caused a delay in the conversion of phagosomes into lysosomes and in phagosomal acidification, whereas production of reactive oxygen species (ROS) increased. Elevated ROS resulted in reduced activ",{"id":548,"funder":7,"programme":8,"title":543,"piName":544,"institution":545,"country":12,"year":13,"amount":14,"abstract":546},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-vidi-864-14-001",{"id":550,"funder":7,"programme":8,"title":543,"piName":544,"institution":545,"country":12,"year":13,"amount":14,"abstract":546},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vidi-864-14-001",{"id":552,"funder":7,"programme":8,"title":553,"piName":554,"institution":44,"country":12,"year":13,"amount":14,"abstract":555},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-14637-","Robust and Fast Markov Chain Monte Carlo Sampling of Diffusion MRI Microstructure Models","Robbert Harms","In diffusion MRI analysis, advances in biophysical multi-compartment modeling have gained popularity over the conventional Diffusion Tensor Imaging (DTI), because they can obtain a greater specificity in relating the dMRI signal to underlying cellular microstructure. Biophysical multi-compartment models require a parameter estimation, typically performed using either the Maximum Likelihood Estimation (MLE) or the Markov Chain Monte Carlo (MCMC) sampling. Whereas, the MLE provides only a point es",{"id":557,"funder":7,"programme":8,"title":558,"piName":559,"institution":560,"country":105,"year":13,"amount":14,"abstract":561},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-14-004","Minimum Information about an Uncultivated Virus Genome (MIUViG)","Simon Roux","Joint Genome Institute","We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minim",{"id":563,"funder":7,"programme":8,"title":564,"piName":565,"institution":44,"country":12,"year":13,"amount":14,"abstract":566},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-917-13-350","Telemedicine in heart failure—more than nice to have?","Casper Eurlings","Telemedicine in chronic diseases like heart failure is rapidly evolving and has two important goals: improving and individualising care as well as reducing costs. In this paper, we provide a critical and an updated review of the current evidence by discussing the most important trials, meta-analyses and systematic reviews. So far, evidence for the CardioMEMS device is most convincing. Other trials regarding invasive and non-invasive telemonitoring and telephone support show divergent results, bu",{"id":568,"funder":7,"programme":8,"title":197,"piName":198,"institution":569,"country":12,"year":13,"amount":14,"abstract":200},"openalex-nederlandse-organisatie-voor-wetenschapp-award-innovational-research-incentives-scheme-vidi","Space Research Organisation Netherlands",{"id":571,"funder":7,"programme":8,"title":572,"piName":573,"institution":574,"country":12,"year":13,"amount":14,"abstract":575},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-17-003","Chiefs in the City: Traditional Authority in the Modern State","Joris Tieleman","Erasmus University Rotterdam","While forms of authority that descend from social or cultural tradition are commonly understood as archaic, traditional authorities often survive and occasionally even thrive during the formation of modern states. Chieftaincies do not only endure in the Ghanaian countryside but also proliferate in new neighbourhoods on the peripheries of Ghana’s fast-growing cities. We develop an explanation for the endurance of traditional authorities, based on extensive fieldwork in one recently developed neig",{"id":577,"funder":7,"programme":8,"title":578,"piName":579,"institution":435,"country":12,"year":13,"amount":14,"abstract":580},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-14134","Evolutionary Game Dynamics for Two Interacting Populations in A Co-evolving Environment","Lulu Gong","We study the evolutionary dynamics of games under environmental feedback using replicator equations for two interacting populations. One key feature is to consider jointly the co-evolution of the dynamic payoff matrices and the state of the environment: the payoff matrix varies with the changing environment and at the same time, the state of the environment is affected indirectly by the changing payoff matrix through the evolving population profiles. For such co-evolutionary dynamics, we investi",{"id":582,"funder":7,"programme":8,"title":583,"piName":584,"institution":14,"country":14,"year":13,"amount":14,"abstract":585},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-012-105","A QM\u002FMM Derived Polarizable Water Model for Molecular Simulation","Daan P. Geerke","In this work, we propose an improved QM\u002FMM-based strategy to determine condensed-phase polarizabilities and we use this approach to optimize a new and simple polarizable four-site water model for classical molecular simulation. For the determination of the model value for the polarizability from QM\u002FMM, we show that our proposed consensus-fitting strategy significantly reduces the uncertainty in calculated polarizabilities in cases where the size of the local external electric field is small. By ",{"id":587,"funder":7,"programme":8,"title":588,"piName":589,"institution":590,"country":12,"year":13,"amount":14,"abstract":591},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-14-015","Action perception recruits the cerebellum and is impaired in spinocerebellar ataxia patients","Abdel R. Abdelgabar","Netherlands Institute for Neuroscience","Abstract Our cerebellum has been proposed to generate prediction signals that may help us plan and execute our motor programs. However, to what extent our cerebellum is also actively involved in perceiving the action of others remains to be elucidated. Using fMRI, we show here that observing goal-directed hand actions of others bilaterally recruits cerebellar Lobules VI, VIIb and VIIIa. Moreover, whereas healthy subjects (n=31) were found to be able to discriminate subtle differences in the kine",114,{"programme":8,"total":594,"withPiName":594,"firstYear":595,"lastYear":596,"countryCount":597,"perYear":598,"topInstitutions":648,"topCountries":694},788,2008,2026,33,[599,601,604,606,609,612,615,618,621,624,625,628,631,634,637,640,643,646],{"year":595,"count":600},1,{"year":602,"count":603},2009,2,{"year":605,"count":600},2011,{"year":607,"count":608},2012,3,{"year":610,"count":611},2013,5,{"year":613,"count":614},2014,6,{"year":616,"count":617},2015,15,{"year":619,"count":620},2016,41,{"year":622,"count":623},2017,58,{"year":13,"count":592},{"year":626,"count":627},2019,28,{"year":629,"count":630},2020,39,{"year":632,"count":633},2021,34,{"year":635,"count":636},2022,37,{"year":638,"count":639},2023,66,{"year":641,"count":642},2024,116,{"year":644,"count":645},2025,133,{"year":596,"count":647},89,[649,651,653,655,657,658,659,661,663,665,666,667,669,671,673,674,676,679,681,683,685,687,688,689,691],{"name":63,"count":650},63,{"name":118,"count":652},60,{"name":435,"count":654},52,{"name":38,"count":656},40,{"name":32,"count":636},{"name":80,"count":627},{"name":20,"count":660},25,{"name":228,"count":662},19,{"name":50,"count":664},17,{"name":163,"count":664},{"name":44,"count":664},{"name":574,"count":668},16,{"name":282,"count":670},14,{"name":26,"count":672},12,{"name":74,"count":672},{"name":11,"count":675},11,{"name":677,"count":678},"Centre National de la Recherche Scientifique",8,{"name":680,"count":678},"Institute for Atomic and Molecular Physics",{"name":429,"count":682},7,{"name":684,"count":682},"University of Twente",{"name":686,"count":614},"Amsterdam University of Applied Sciences",{"name":590,"count":614},{"name":412,"count":614},{"name":690,"count":611},"Royal Netherlands Institute for Sea Research",{"name":692,"count":693},"Amsterdam University Medical Centers",4,[695,697,699,701,703,706,708,709,710,711,713,714,715,717,718,720,722,724,726,727,729,731,733,734,736],{"name":12,"count":696},558,{"name":333,"count":698},30,{"name":105,"count":700},27,{"name":57,"count":702},21,{"name":704,"count":705},"FR",13,{"name":372,"count":707},9,{"name":87,"count":707},{"name":468,"count":678},{"name":193,"count":682},{"name":712,"count":611},"AU",{"name":361,"count":611},{"name":112,"count":611},{"name":716,"count":611},"ES",{"name":93,"count":693},{"name":719,"count":693},"BR",{"name":721,"count":608},"IE",{"name":723,"count":603},"HU",{"name":725,"count":603},"PL",{"name":253,"count":603},{"name":728,"count":603},"SG",{"name":730,"count":603},"ZA",{"name":732,"count":600},"AE",{"name":260,"count":600},{"name":735,"count":600},"BD",{"name":737,"count":600},"CL"]