[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2019":3,"awarded-stats-nwo-vidi":154},{"awarded":4,"total":153},[5,16,22,28,34,39,45,51,57,63,68,74,76,81,83,90,96,103,108,113,119,124,129,135,137,143,149,151],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-700-10-421","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair","Puck Knipscheer","University Medical Center Utrecht","NL",2019,null,"The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability and DNA interstrand crosslink (ICL) repair in vertebrates. We show that ectopic production of HSF2BP, a BRCA2-interacting protein required for meiotic HR during mouse spermatogenesis, in non-germline human cells acutely sensitize them to ICL-inducing agents (mitomycin C and cisplatin) and PARP inhibitors, resulting in a phenotype characteristic of cells from Fanconi anemia (FA) patients. We bioc",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":12,"year":13,"amount":14,"abstract":21},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-vidi-171-061","On the stability of sequences inserted into viral genomes","Mark P. Zwart","Netherlands Institute of Ecology","Viruses are widely used as vectors for heterologous gene expression in cultured cells or natural hosts, and therefore a large number of viruses with exogenous sequences inserted into their genomes have been engineered. Many of these engineered viruses are viable and express heterologous proteins at high levels, but the inserted sequences often prove to be unstable over time and are rapidly lost, limiting heterologous protein expression. Although virologists are aware that inserted sequences can ",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-13455","Thermoresponsive Brushes Facilitate Effective Reinforcement of Calcium Phosphate Cements","Daniela A. Wilson","Radboud University Nijmegen","-isopropylacrylamide) brushes of tunable thickness to improve simultaneously fiber dispersion and fiber-matrix affinity. These brushes shift from hydrophilic to hydrophobic behavior at temperatures above their lower critical solution temperature of 32 °C. This dual thermoresponsive shift favors fiber dispersion throughout the hydrophilic calcium phosphate cements (at 21 °C) and toughens these cements when reaching their hydrophobic state (at 37 °C). The reinforcement efficacy of these surface-mo",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":33,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864","Changes to virus taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2019)","Arcady Mushegian","U.S. National Science Foundation","US",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":26,"country":12,"year":13,"amount":14,"abstract":38},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-013-003","Facilities that make the PDB data collection more powerful","Gert Vriend","We describe a series of databases and tools that directly or indirectly support biomedical research on macromolecules, with focus on their applicability in protein structure bioinformatics research. DSSP, that determines secondary structures of proteins, has been updated to work well with extremely large structures in multiple formats. The PDBREPORT database that lists anomalies in protein structures has been remade to remove many small problems. These reports are now available as PDF-formatted ",{"id":40,"funder":7,"programme":8,"title":41,"piName":42,"institution":43,"country":12,"year":13,"amount":14,"abstract":44},"openalex-nederlandse-organisatie-voor-wetenschapp-award-700-54-425-vidi-","The human cytomegalovirus-encoded G protein–coupled receptor UL33 exhibits oncomodulatory properties","Martine J. Smit","Vrije Universiteit Amsterdam","tumor models, including an orthotopic glioblastoma xenograft model. UL33-mediated signaling was similar to that stimulated by US28; however, UL33-induced tumor growth was delayed. Additionally, the spatiotemporal expression of the two receptors only partially overlapped in HCMV-infected glioblastoma cells. In conclusion, our results unveil that UL33 has broad signaling capacity and provide mechanistic insight into its functional effects. UL33, like US28, exhibits oncomodulatory properties, elici",{"id":46,"funder":7,"programme":8,"title":47,"piName":48,"institution":49,"country":12,"year":13,"amount":14,"abstract":50},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-wotro-vidi-w01-70-300-002","'He usually has what we call normal fevers’: Cultural perspectives on healthy child growth in rural Southeastern Tanzania: An ethnographic enquiry","Zaina Mchome","University of Groningen","INTRODUCTION: While parents' construction of and actions around child growth are embedded in their cultural framework, the discourse on child growth monitoring (CGM) has been using indicators grounded in the biomedical model. We believe that for CGM to be effective, it should also incorporate other relevant socio-cultural constructs. To contribute to the further development of CGM to ensure that it reflects the local context, we report on the cultural conceptualization of healthy child growth in",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":55,"country":12,"year":13,"amount":14,"abstract":56},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-number-864-13-011","Seasonal and regional variations of sinking in the subpolar North Atlantic from a high-resolution ocean model","Juan‐Manuel Sayol","Delft University of Technology","Abstract. Previous studies have indicated that most of the net sinking associated with the downward branch of the Atlantic Meridional Overturning Circulation (AMOC) must occur near the subpolar North Atlantic boundaries. In this work we have used monthly mean fields of a high-resolution ocean model (0.1∘ at the Equator) to quantify this sinking. To this end we have calculated the Eulerian net vertical transport (W∑) from the modeled vertical velocities, its seasonal variability, and its spatial ",{"id":58,"funder":7,"programme":8,"title":59,"piName":60,"institution":61,"country":12,"year":13,"amount":14,"abstract":62},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-016-161-318","FungalRoot: Global online database of plant mycorrhizal associations","Nadejda A. Soudzilovskaia","Leiden University","Summary The urgent need to better understand profound impacts of mycorrhizas on functioning of terrestrial ecosystems, along with recent debates on resolving plant mycorrhizal associations, indicate that there is a great need for a comprehensive data of plant mycorrhizal associations able to support testing of ecological, biogeographic and phylogenetic hypotheses. Here present a database, FungalRoot, which summarizes publicly available data on plant mycorrhizal type and intensity of root coloniz",{"id":64,"funder":7,"programme":8,"title":65,"piName":66,"institution":49,"country":12,"year":13,"amount":14,"abstract":67},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-talent-scheme-723-015-005","Ruthenium and Iron‐Catalysed Decarboxylative \u003Ci>N\u003C\u002Fi>‐alkylation of Cyclic α‐Amino Acids with Alcohols: Sustainable Routes to Pyrrolidine and Piperidine Derivatives","Katalin Barta","A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of α-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction ",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":12,"year":13,"amount":14,"abstract":73},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-639-042-525","X-ray extinction from interstellar dust","E. Costantini","Space Research Organisation Netherlands","Aims. We present a study on the prospects of observing carbon, sulfur, and other lower abundance elements (namely Al, Ca, Ti, and Ni) present in the interstellar medium using future X-ray instruments. We focus in particular on the detection and characterization of interstellar dust along the lines of sight. Methods. We compared the simulated data with different sets of dust aggregates, either obtained from past literature or measured by us using the SOLEIL-LUCIA synchrotron beamline. Extinction ",{"id":75,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-015-001",{"id":77,"funder":7,"programme":8,"title":78,"piName":79,"institution":49,"country":12,"year":13,"amount":14,"abstract":80},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-014-008","Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity","Frank J. Dekker","Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-κB signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions. In this study, a novel potent 15-LOX-1 inhibito",{"id":82,"funder":7,"programme":8,"title":78,"piName":79,"institution":49,"country":12,"year":13,"amount":14,"abstract":80},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-122-302",{"id":84,"funder":7,"programme":8,"title":85,"piName":86,"institution":87,"country":88,"year":13,"amount":14,"abstract":89},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-014-004-","Formazanate coordination compounds: synthesis, reactivity, and applications","Joe B. Gilroy","Western University","CA","Formazans (Ar1-NH-N[double bond, length as m-dash]CR3-N[double bond, length as m-dash]N-Ar5), a class of nitrogen-rich and highly colored compounds, have been known since the late 1800s and studied more closely since the early 1940s. Their intense color has led to their widespread use as dyes, especially in cell biology where they are most often used to quantitatively assess cell-viability. Despite structural similarities to well-known ligand classes such as β-diketiminates, the deprotonated for",{"id":91,"funder":7,"programme":8,"title":92,"piName":93,"institution":94,"country":12,"year":13,"amount":14,"abstract":95},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-917-13-338","Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 \u003Csup>+\u003C\u002Fsup> T cells in the bone marrow","María Fernanda Pascutti","Sanquin","Abstract BM has been put forward as a major reservoir for memory CD8 + T cells. In order to fulfill that function, BM should “store” memory CD8 + T cells, which in biological terms would require these “stored” memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Here, we unequivocally demonstrate that murine and human BM harbors a population of tissue‐resident memory CD8 + T (T RM ) cells. These cells develop against various pathogens, indepen",{"id":97,"funder":7,"programme":8,"title":98,"piName":99,"institution":100,"country":101,"year":13,"amount":14,"abstract":102},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-864-13-012","Methods for computing the maximum performance of computational models of fMRI responses","Agustín Lage‐Castellanos","Cuban Neuroscience Center","CU","Computational neuroimaging methods aim to predict brain responses (measured e.g. with functional magnetic resonance imaging [fMRI]) on the basis of stimulus features obtained through computational models. The accuracy of such prediction is used as an indicator of how well the model describes the computations underlying the brain function that is being considered. However, the prediction accuracy is bounded by the proportion of the variance of the brain response which is related to the measuremen",{"id":104,"funder":7,"programme":8,"title":105,"piName":106,"institution":61,"country":12,"year":13,"amount":14,"abstract":107},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-12-008","Civil Society Engagement and Policy Representation in Europe","Anne Rasmussen","Since Tocqueville linked the quality of democracy in America to its vibrant civic culture, studies have explored the relationship between social capital and the quality of governance. Yet, few have examined the mechanisms between individual components of social capital and democracy in depth. This study focuses on the link between one component of social capital, civil society engagement, and the linkage between public opinion and policy. It argues that engagement in associations with an interes",{"id":109,"funder":7,"programme":8,"title":110,"piName":111,"institution":26,"country":12,"year":13,"amount":14,"abstract":112},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-864-12-00","Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states","René A. M. Dirks","BACKGROUND: Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from early embryonic tissues between E3.5 and E7.25 and in pluripotent cell lines to evaluate maintenance of imprinted gene expression. For the cell lines, we include embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) derived from fertilized embryos and f",{"id":114,"funder":7,"programme":8,"title":115,"piName":116,"institution":117,"country":12,"year":13,"amount":14,"abstract":118},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-016-056-337","T‐cell responses against 4‐ \u003Ci>tert\u003C\u002Fi> ‐butylphenol‐exposed pigmented cells in a patient with occupational vitiligo","Charlotte Vrijman","Amsterdam University Medical Centers","T-cell responses against 4-tert-butylphenolexposed pigmented cells in a patient with occupational vitiligo",{"id":120,"funder":7,"programme":8,"title":121,"piName":122,"institution":49,"country":12,"year":13,"amount":14,"abstract":123},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-012-001","Lewis Acid Promoted Trapping of Chiral Aza-enolates","Syuzanna R. Harutyunyan","We present a study on sequential conjugate addition of ­Grignard reagents to alkenyl-heteroarenes followed by trapping of the resulting enolates, yielding moderate to good diastereoselectivities. Contrary to conventional wisdom, one-pot conjugate addition\u002Ftrapping using two reactive Michael acceptors in combination with Grignard reagents can proceed via conjugate addition to the least reactive Michael acceptor. This unusual chemoselectivity is triggered by the presence of a Lewis acid, reverting",{"id":125,"funder":7,"programme":8,"title":126,"piName":127,"institution":72,"country":12,"year":13,"amount":14,"abstract":128},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-639-042-423","Mitigation of cosmic ray effect on microwave kinetic inductance detector arrays","K. Karatsu","For space observatories, the glitches caused by high energy phonons created by the interaction of cosmic ray particles with a detector substrate lead to dead time during observation. Mitigating the impact of cosmic rays is therefore an important requirement for detectors to be used in future space missions. In order to investigate possible solutions, we carry out a systematic study by testing four large arrays of Microwave Kinetic Inductance Detectors (MKIDs), each consisting of ∼960 pixels and ",{"id":130,"funder":7,"programme":8,"title":131,"piName":132,"institution":133,"country":134,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-vidi-201-059","Investor Memory","Katrin Gödker","Bocconi University","IT",{"id":136,"funder":7,"programme":8,"title":131,"piName":132,"institution":133,"country":134,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-vidi-221e-011",{"id":138,"funder":7,"programme":8,"title":139,"piName":140,"institution":141,"country":142,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-vidi-178-052","Optimizing BOLD sensitivity in the 7T Human Connectome Project resting-state fMRI protocol using plug-and-play parallel transmission","Vincent Gras","CEA Paris-Saclay","FR",{"id":144,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":12,"year":13,"amount":14,"abstract":148},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-2018-2023","The concept of language of trust and trustworthiness: (Why) history matters","Justyna Wubs‐Mrozewicz","University of Amsterdam","This paper puts forward the argument that the concept of the language of trust and trustworthiness can be a useful way of understanding what trust means in specific situations. This concept refers to linguistic devices – verbal and non-verbal – which purposefully convey trust and create a foundation for continuing or improving relations. The concept has been developed based on research into relations between premodern merchants and their urban governments. In this context, the language of trust ",{"id":150,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":12,"year":13,"amount":14,"abstract":148},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-174-012",{"id":152,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":12,"year":13,"amount":14,"abstract":148},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-174-012-3261",28,{"programme":8,"total":155,"withPiName":155,"firstYear":156,"lastYear":157,"countryCount":158,"perYear":159,"topInstitutions":209,"topCountries":265},788,2008,2026,33,[160,162,165,167,170,173,176,179,182,185,188,189,192,195,198,201,204,207],{"year":156,"count":161},1,{"year":163,"count":164},2009,2,{"year":166,"count":161},2011,{"year":168,"count":169},2012,3,{"year":171,"count":172},2013,5,{"year":174,"count":175},2014,6,{"year":177,"count":178},2015,15,{"year":180,"count":181},2016,41,{"year":183,"count":184},2017,58,{"year":186,"count":187},2018,114,{"year":13,"count":153},{"year":190,"count":191},2020,39,{"year":193,"count":194},2021,34,{"year":196,"count":197},2022,37,{"year":199,"count":200},2023,66,{"year":202,"count":203},2024,116,{"year":205,"count":206},2025,133,{"year":157,"count":208},89,[210,213,215,217,219,220,221,224,227,230,232,234,237,239,242,243,246,249,251,253,255,257,259,261,263],{"name":211,"count":212},"Utrecht University",63,{"name":26,"count":214},60,{"name":49,"count":216},52,{"name":147,"count":218},40,{"name":61,"count":197},{"name":55,"count":153},{"name":222,"count":223},"Wageningen University & Research",25,{"name":225,"count":226},"University Medical Center Groningen",19,{"name":228,"count":229},"Eindhoven University of Technology",17,{"name":231,"count":229},"Erasmus MC",{"name":233,"count":229},"Maastricht University",{"name":235,"count":236},"Erasmus University Rotterdam",16,{"name":43,"count":238},14,{"name":240,"count":241},"Amsterdam Neuroscience",12,{"name":11,"count":241},{"name":244,"count":245},"Leiden University Medical Center",11,{"name":247,"count":248},"Centre National de la Recherche Scientifique",8,{"name":250,"count":248},"Institute for Atomic and Molecular Physics",{"name":20,"count":252},7,{"name":254,"count":252},"University of Twente",{"name":256,"count":175},"Amsterdam University of Applied Sciences",{"name":258,"count":175},"Netherlands Institute for Neuroscience",{"name":260,"count":175},"Tilburg University",{"name":262,"count":172},"Royal Netherlands Institute for Sea Research",{"name":117,"count":264},4,[266,268,271,273,276,278,281,283,284,286,288,289,291,293,295,297,299,301,303,305,307,309,311,313,315],{"name":12,"count":267},558,{"name":269,"count":270},"DE",30,{"name":33,"count":272},27,{"name":274,"count":275},"GB",21,{"name":142,"count":277},13,{"name":279,"count":280},"BE",9,{"name":282,"count":280},"CH",{"name":134,"count":248},{"name":285,"count":252},"CN",{"name":287,"count":172},"AU",{"name":88,"count":172},{"name":290,"count":172},"DK",{"name":292,"count":172},"ES",{"name":294,"count":264},"AT",{"name":296,"count":264},"BR",{"name":298,"count":169},"IE",{"name":300,"count":164},"HU",{"name":302,"count":164},"PL",{"name":304,"count":164},"SE",{"name":306,"count":164},"SG",{"name":308,"count":164},"ZA",{"name":310,"count":161},"AE",{"name":312,"count":161},"AR",{"name":314,"count":161},"BD",{"name":316,"count":161},"CL"]