[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-vidi-2021":3,"awarded-stats-nwo-vidi":204},{"awarded":4,"total":203},[5,16,23,29,35,41,47,53,59,64,69,75,80,85,91,97,103,110,115,122,128,133,135,142,148,153,159,164,169,175,181,186,192,198],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-ttw-016-vidi-188-007","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Vidi","Oxygen releasing hydrogels for beta cell assisted therapy","Firoz Babu Kadumudi","Technical University of Denmark","DK",2021,null,"Diabetes is a serious chronic disease, which globally affects more than 400 million patients. Beta cell therapy has potential to serve as an effective cure to type 1 diabetes and several studies have already shown promising results in this regard. One of the major obstacles in cell therapy, however, is the hypoxic environment that therapeutic cells are subjected to immediately after the transplantation. In this study, a new approach is presented, based on hydrogels composed of thiolated hyaluron",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-vidi-191-135","Fair Teachers, Fair Police? Assessing the Pathways between Perceptions of Teacher and Police Authority in Childhood and Adolescence","Amy Nivette","University of Applied Sciences Utrecht","NL","Existing research has shown that the quality of the relationship between teacher and child is associated with more positive perceptions of school authorities. There has been relatively less attention to the processes that connect attitudes towards different sources of authority, such as between teachers and police. The current study uses a counterfactual approach to estimate the direct and indirect effects of teacher-child relationships on children's later perceptions of police legitimacy. Using",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":21,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-188-021","Osteoblast-osteoclast co-cultures: A systematic review and map of available literature","Sandra Hofmann","Eindhoven University of Technology","Drug research with animal models is expensive, time-consuming and translation to clinical trials is often poor, resulting in a desire to replace, reduce, and refine the use of animal models. One approach to replace and reduce the use of animal models is to use in vitro cell-culture models. To study bone physiology, bone diseases and drugs, many studies have been published using osteoblast-osteoclast co-cultures. The use of osteoblast-osteoclast co-cultures is usually not clearly mentioned in the",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":21,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-16-004","How to capture developmental brain dynamics: gaps and solutions","Nienke van Atteveldt","Vrije Universiteit Amsterdam","Capturing developmental and learning-induced brain dynamics is extremely challenging as changes occur interactively across multiple levels and emerging functions. Different levels include the (social) environment, cognitive and behavioral levels, structural and functional brain changes, and genetics, while functions include domains such as math, reading, and executive function. Here, we report the insights that emerged from the workshop “Capturing Developmental Brain Dynamics”, organized to brin",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":40,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-185-044","Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits","Andries T. Marees","QIMR Berghofer Medical Research Institute","AU",{"id":42,"funder":7,"programme":8,"title":43,"piName":44,"institution":45,"country":21,"year":13,"amount":14,"abstract":46},"openalex-nederlandse-organisatie-voor-wetenschapp-award-ethnoontologies-vi-vidi-195-026","The role of political ontology for Indigenous self-determination","Matthias Kramm","Wageningen University & Research","In this paper, I defend the claim that addressing dominating ontologies is crucial for achieving Indigenous self-determination. Consequently, the struggle for Indigenous self-determination comprises not only an engagement with political practices, structures, and institutions, but also with political ontology. I first argue that implementing Indigenous self-determination requires an engagement with political ontology. I then introduce Iris Young’s conception of self-determination as non-dominati",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":51,"country":21,"year":13,"amount":14,"abstract":52},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-639-072-410","Foundations of structural causal models with cycles and latent variables","Stephan Bongers","University of Amsterdam","Structural causal models (SCMs), also known as (nonparametric) structural equation models (SEMs), are widely used for causal modeling purposes. In particular, acyclic SCMs, also known as recursive SEMs, form a well-studied subclass of SCMs that generalize causal Bayesian networks to allow for latent confounders. In this paper, we investigate SCMs in a more general setting, allowing for the presence of both latent confounders and cycles. We show that in the presence of cycles, many of the conveni",{"id":54,"funder":7,"programme":8,"title":55,"piName":56,"institution":57,"country":21,"year":13,"amount":14,"abstract":58},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-14-004","Finding functional associations between prokaryotic virus orthologous groups: a proof of concept","Nikolaos Pappas","Utrecht University","BACKGROUND: The field of viromics has greatly benefited from recent developments in metagenomics, with significant efforts focusing on viral discovery. However, functional annotation of the increasing number of viral genomes is lagging behind. This is highlighted by the degree of annotation of the protein clusters in the prokaryotic Virus Orthologous Groups (pVOGs) database, with 83% of its current 9518 pVOGs having an unknown function. RESULTS: In this study we describe a machine learning appro",{"id":60,"funder":7,"programme":8,"title":61,"piName":62,"institution":57,"country":21,"year":13,"amount":14,"abstract":63},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-91715372","Glycan remodeled erythrocytes facilitate antigenic characterization of recent A\u002FH3N2 influenza viruses","Robert P. de Vries","During circulation in humans and natural selection to escape antibody recognition for decades, A\u002FH3N2 influenza viruses emerged with altered receptor specificities. These viruses lost the ability to agglutinate erythrocytes critical for antigenic characterization and give low yields and acquire adaptive mutations when cultured in eggs and cells, contributing to recent vaccine challenges. Examination of receptor specificities of A\u002FH3N2 viruses reveals that recent viruses compensated for decreased",{"id":65,"funder":7,"programme":8,"title":66,"piName":67,"institution":20,"country":21,"year":13,"amount":14,"abstract":68},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-723-014-005","Metabolic Labeling of Legionaminic Acid in Flagellin Glycosylation of \u003Ci>Campylobacter jejuni\u003C\u002Fi> Identifies Maf4 as a Putative Legionaminyl Transferase","Marc M. S. M. Wösten","Campylobacter jejuni is the major human food-borne pathogen. Its bipolar flagella are heavily O-glycosylated with microbial sialic acids and essential for its motility and pathogenicity. However, both the glycosylation of flagella and the exact contribution of legionaminic acid (Leg) to flagellar activity is poorly understood. Herein, we report the development of a metabolic labeling method for Leg glycosylation on bacterial flagella with probes based on azide-modified Leg precursors. The hereby",{"id":70,"funder":7,"programme":8,"title":71,"piName":72,"institution":73,"country":21,"year":13,"amount":14,"abstract":74},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vi-vidi-195-083","Does Danger Level Affect Bystander Intervention in Real-Life Conflicts? Evidence From CCTV Footage","Marie Rosenkrantz Lindegaard","Netherlands Institute for the Study of Crime and Law Enforcement","In real-life violence, bystanders can take an active role in de-escalating conflict and helping others. Recent meta-analytical evidence of experimental studies suggests that elevated danger levels in conflicts facilitate bystander intervention. However, this finding may lack ecological validity because ethical concerns prohibit exposing participants to potentially harmful situations. Using an ecologically valid method, based on an analysis of 80 interpersonal conflicts unobtrusively recorded by ",{"id":76,"funder":7,"programme":8,"title":77,"piName":78,"institution":57,"country":21,"year":13,"amount":14,"abstract":79},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-vidi-864-13-006","Proximal to distal grain‐size distribution of basin‐floor lobes: A study from the Battfjellet Formation, Central Tertiary Basin, Svalbard","Yvonne Spychala","Abstract The grain‐size distribution of sediment particles is an important aspect of the architecture of submarine fans and lobes. It governs depositional sand quality and reflects distribution of particulate organic carbon and pollutants. Documenting the grain‐size distribution of these deep‐marine sedimentary bodies can also offer us an insight into the flows that deposited them. Submarine lobes are commonly assumed to linearly fine from an apex, meaning there should be a proportional relation",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":45,"country":21,"year":13,"amount":14,"abstract":84},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-no-680-47-548-983","Inverted and Programmable Poynting Effects in Metamaterials","Aref Ghorbani","The Poynting effect generically manifests itself as the extension of the material in the direction perpendicular to an applied shear deformation (torsion) and is a material parameter hard to design. Unlike isotropic solids, in designed structures, peculiar couplings between shear and normal deformations can be achieved and exploited for practical applications. Here, a metamaterial is engineered that can be programmed to contract or extend under torsion and undergo nonlinear twist under compressi",{"id":86,"funder":7,"programme":8,"title":87,"piName":88,"institution":89,"country":21,"year":13,"amount":14,"abstract":90},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-grant-917-14-374","Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility","Lude Franke","University Medical Center Groningen","Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection. Recently, it was shown that it is possible to predict COVID-19 cases using cross-sectional self-reported disease-related symptoms. Here, we demonstrate that this COVID-19 prediction model has reasonable and consistent performance across multiple independent cohorts and that our attempt to improve upon this model did not result in improved prediction",{"id":92,"funder":7,"programme":8,"title":93,"piName":94,"institution":95,"country":21,"year":13,"amount":14,"abstract":96},"openalex-nederlandse-organisatie-voor-wetenschapp-award-grant-016-vidi-189-050","Proteogenomic analysis of \u003Ci>Georgfuchsia toluolica\u003C\u002Fi> revealed unexpected concurrent aerobic and anaerobic toluene degradation","Siavash Atashgahi","Radboud University Nijmegen","Denitrifying Betaproteobacteria play a key role in the anaerobic degradation of monoaromatic hydrocarbons. We performed a multi-omics study to better understand the metabolism of the representative organism Georgfuchsia toluolica strain G5G6 known as a strict anaerobe coupling toluene oxidation with dissimilatory nitrate and Fe(III) reduction. Despite the genomic potential for degradation of different carbon sources, we did not find sugar or organic acid transporters, in line with the inability ",{"id":98,"funder":7,"programme":8,"title":99,"piName":100,"institution":101,"country":21,"year":13,"amount":14,"abstract":102},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-156-318","Atypical development of subcortico-cortical effective connectivity in autism","Luigi Lorenzini","Amsterdam Neuroscience","Abstract Hypersensitivity, stereotyped behaviors and attentional problems in autism spectrum disorder (ASD) are compatible with inefficient filtering of undesired or irrelevant sensory information at early stages of neural processing. This could stem from delays in the neurotypical development of the functional segregation between cortical and subcortical brain processes, as suggested by previous findings of overconnectivity between primary sensory regions and deep brain nuclei in ASD. To test t",{"id":104,"funder":7,"programme":8,"title":105,"piName":106,"institution":107,"country":108,"year":13,"amount":14,"abstract":109},"openalex-nederlandse-organisatie-voor-wetenschapp-award-tti-vidi-12988","Introgression of the sesquiterpene biosynthesis from Solanum habrochaites to cultivated tomato offers insights into trichome morphology and arthropod resistance","Rodrigo Therezan","Universidade de São Paulo","BR","MAIN CONCLUSION: Cultivated tomatoes harboring the plastid-derived sesquiterpenes from S. habrochaites have altered type-VI trichome morphology and unveil additional genetic components necessary for piercing-sucking pest resistance. Arthropod resistance in the tomato wild relative Solanum habrochaites LA1777 is linked to specific sesquiterpene biosynthesis. The Sesquiterpene synthase 2 (SsT2) gene cluster on LA1777 chromosome 8 controls plastid-derived sesquiterpene synthesis. The main genes at ",{"id":111,"funder":7,"programme":8,"title":112,"piName":113,"institution":51,"country":21,"year":13,"amount":14,"abstract":114},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-452-17-011-","Social Media Use and Adolescents’ Well-Being: Developing a Typology of Person-Specific Effect Patterns","Ine Beyens","This study investigated the effects of active private, passive private, and passive public social media use on adolescents’ affective well-being. Intensive longitudinal data (34,930 assessments in total) were collected through a preregistered three-week experience sampling method study among 387 adolescents. N = 1 time series were investigated, using Dynamic Structural Equation Modeling. Findings showed that different types of social media use very rarely yielded different effects within one and",{"id":116,"funder":7,"programme":8,"title":117,"piName":118,"institution":119,"country":120,"year":13,"amount":14,"abstract":121},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-016-161-365","InterCarb: A Community Effort to Improve Interlaboratory Standardization of the Carbonate Clumped Isotope Thermometer Using Carbonate Standards","Stefano M. Bernasconi","ETH Zurich","CH","Abstract Increased use and improved methodology of carbonate clumped isotope thermometry has greatly enhanced our ability to interrogate a suite of Earth‐system processes. However, interlaboratory discrepancies in quantifying carbonate clumped isotope (Δ 47 ) measurements persist, and their specific sources remain unclear. To address interlaboratory differences, we first provide consensus values from the clumped isotope community for four carbonate standards relative to heated and equilibrated g",{"id":123,"funder":7,"programme":8,"title":124,"piName":125,"institution":126,"country":21,"year":13,"amount":14,"abstract":127},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-16-012","The COVID-19 outbreak increases maternal stress during pregnancy, but not the risk for postpartum depression","Myrthe G. B. M. Boekhorst","Tilburg University","The COVID-19 pandemic affects society and may especially have an impact on mental health of vulnerable groups, such as perinatal women. This prospective cohort study of 669 participating women in the Netherlands compared perinatal symptoms of depression and stress during and before the pandemic. After a pilot in 2018, recruitment started on 7 January 2019. Up until 1 March 2020 (before the pandemic), 401 women completed questionnaires during pregnancy, of whom 250 also completed postpartum asses",{"id":129,"funder":7,"programme":8,"title":130,"piName":131,"institution":57,"country":21,"year":13,"amount":14,"abstract":132},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-452-14-008","Conflictual Accountability: Behavioral Responses to Conflictual Accountability of Agencies","Thomas Schillemans","In contemporary public governance, leaders of public organizations are faced with multiple, and oftentimes conflictual, accountability claims. Drawing upon a survey of CEO’s of agencies in seven countries, we explore whether and how conflictual accountability regimes relate to strategic behaviors by agency-CEO’s and their political principals. The presence of conflictual accountability is experienced as a major challenge and is associated with important behavioral responses by those CEO’s. This ",{"id":134,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":40,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-0-16-vidi-185-044",{"id":136,"funder":7,"programme":8,"title":137,"piName":138,"institution":139,"country":140,"year":13,"amount":14,"abstract":141},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-016-vidi-185-137","Spontaneous neural oscillations influence behavior and sensory representations by suppressing neuronal excitability","Luca Iemi","New York Psychoanalytic Society and Institute","US","Abstract The ability to process and respond to external input is critical for adaptive behavior. Why, then, do neural and behavioral responses vary across repeated presentations of the same sensory input? Spontaneous fluctuations of neuronal excitability are currently hypothesized to underlie the trial-by-trial variability in sensory processing. To test this, we capitalized on invasive electrophysiology in neurosurgical patients performing an auditory discrimination task with visual cues: specif",{"id":143,"funder":7,"programme":8,"title":144,"piName":145,"institution":146,"country":21,"year":13,"amount":14,"abstract":147},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-vidi-425-14-008","Principals and Agents, or Principals and Stewards? Australian Arms Length Agencies’ Perceptions of Arm’s Length Government Instruments","Sandra van Thiel","Erasmus University Rotterdam","After the large-scale creation of arm's length agencies by governments around the globe, these governments now face the dilemma of how to manage, steer or control these arm's length agencies. Different instruments have been developed, based on either of two theoretical models: principal-agent theory or stewardship theory. Both are based on economic models of man with a principal charging an agent or a steward with a task. Principal-agent theory is based on the principal distrusting the agent to ",{"id":149,"funder":7,"programme":8,"title":150,"piName":151,"institution":95,"country":21,"year":13,"amount":14,"abstract":152},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-639-072-513","End-to-end neural system identification with neural information flow","Katja Seeliger","Neural information flow (NIF) provides a novel approach for system identification in neuroscience. It models the neural computations in multiple brain regions and can be trained end-to-end via stochastic gradient descent from noninvasive data. NIF models represent neural information processing via a network of coupled tensors, each encoding the representation of the sensory input contained in a brain region. The elements of these tensors can be interpreted as cortical columns whose activity enco",{"id":154,"funder":7,"programme":8,"title":155,"piName":156,"institution":157,"country":21,"year":13,"amount":14,"abstract":158},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-864-13-014","Iron-loading is a prominent feature of activated microglia in Alzheimer’s disease patients","Boyd Kenkhuis","Leiden University Medical Center","Abstract Brain iron accumulation has been found to accelerate disease progression in Amyloid β-positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key-players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using histological methods, multispectral immunofluorescence and an automated in-house developed microglia segmentation and analysis pipeline, we studied the occurr",{"id":160,"funder":7,"programme":8,"title":161,"piName":162,"institution":101,"country":21,"year":13,"amount":14,"abstract":163},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-zonmw-vidi-016-156-318","Individual prediction of trauma-focused psychotherapy response in youth with posttraumatic stress disorder using resting-state functional connectivity","Jasper B. Zantvoord","Abstract Randomized controlled trials have shown efficacy of trauma-focused psychotherapies in youth with posttraumatic stress disorder (PTSD). However, response varies considerably among individuals. Currently, no biomarkers are available to assist clinicians in identifying youth who are most likely to benefit from treatment. In this study, we investigated whether resting-state functional magnetic resonance imaging (rs-fMRI) could distinguish between responders and non-responders on the group- ",{"id":165,"funder":7,"programme":8,"title":166,"piName":167,"institution":95,"country":21,"year":13,"amount":14,"abstract":168},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vi-vidi-193-075","Tuple Interpretations for Higher-Order Complexity","Cynthia Kop","We develop a class of algebraic interpretations for many-sorted and higher-order term rewriting systems that takes type information into account. Specifically, base-type terms are mapped to \\emph{tuples} of natural numbers and higher-order terms to functions between those tuples. Tuples may carry information relevant to the type; for instance, a term of type $\\mathsf{nat}$ may be associated to a pair $(\\mathsf{cost}, \\mathsf{size})$ representing its evaluation cost and size. This class of interp",{"id":170,"funder":7,"programme":8,"title":171,"piName":172,"institution":173,"country":140,"year":13,"amount":14,"abstract":174},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-189-174","A comprehensive reanalysis of \u003Ci>Spitzer\u003C\u002Fi>’s 4.5 μm phase curves, and the phase variations of the ultra-hot Jupiters MASCARA-1b and KELT-16b","Taylor J. Bell","NASA Exoplanet Science Institute","ABSTRACT We have developed an open-source pipeline for the analysis of Spitzer\u002FIRAC channel 1 and 2 time-series photometry, incorporating some of the most popular decorrelation methods. We applied this pipeline to new phase curve observations of ultra-hot Jupiters MASCARA-1b and KELT-16b, and we performed the first comprehensive reanalysis of 15 phase curves. We find that MASCARA-1b and KELT-16b have phase offsets of $6^{+11}_{-11}~^{\\circ }$W and $38^{+16}_{-15}~^{\\circ }$W, dayside temperature",{"id":176,"funder":7,"programme":8,"title":177,"piName":178,"institution":179,"country":21,"year":13,"amount":14,"abstract":180},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-723-016-007","Hydrodynamic shear dissipation and transmission in lipid bilayers","Marie‐Eve Aubin‐Tam","Delft University of Technology","Vital biological processes, such as trafficking, sensing, and motility, are facilitated by cellular lipid membranes, which interact mechanically with surrounding fluids. Such lipid membranes are only a few nanometers thick and composed of a liquid crystalline structure known as the lipid bilayer. Here, we introduce an active, noncontact, two-point microrheology technique combining multiple optical tweezers probes with planar freestanding lipid bilayers accessible on both sides. We use the method",{"id":182,"funder":7,"programme":8,"title":183,"piName":184,"institution":101,"country":21,"year":13,"amount":14,"abstract":185},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-452-16-015-","Statistical testing in transcriptomic‐neuroimaging studies: A how‐to and evaluation of methods assessing spatial and gene specificity","Martijn P. van den Heuvel","Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely used approach for exploring the molecular underpinnings of large-scale brain organization in health and disease. Proper statistical evaluation of determined associations between imaging-based phenotypic and transcriptomic data is key in these explorations, in particular to establish whether observed associations exceed \"chance level\" of random, nonspecific effects. Recent approaches have shown the importance",{"id":187,"funder":7,"programme":8,"title":188,"piName":189,"institution":190,"country":21,"year":13,"amount":14,"abstract":191},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-vidi-189-007","How a cell decides its own fate: a single-cell view of molecular mechanisms and dynamics of cell-type specification","Maria Mircea","Leiden University","On its path from a fertilized egg to one of the many cell types in a multicellular organism, a cell turns the blank canvas of its early embryonic state into a molecular profile fine-tuned to achieve a vital organismal function. This remarkable transformation emerges from the interplay between dynamically changing external signals, the cell's internal, variable state, and tremendously complex molecular machinery; we are only beginning to understand. Recently developed single-cell omics techniques",{"id":193,"funder":7,"programme":8,"title":194,"piName":195,"institution":196,"country":21,"year":13,"amount":14,"abstract":197},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-14855","A Flexible Catheter System for Ultrasound-Guided Magnetic Projectile Delivery","J. Sikorski","University of Twente","Magnetic actuation is a versatiletechnology, widely applied in medical robotics for noncontact steering of flexible instruments and untethered agents. In this article, we exploit the benefits of this technology by developing a magnetically actuated flexible catheter capable of the controlled ejection and retrieval of an untethered magnetic capsule. The catheter is actuated by the advanced robotics for magnetic manipulation system. The scanning ultrasound is used for 3-D shape reconstruction of t",{"id":199,"funder":7,"programme":8,"title":200,"piName":201,"institution":157,"country":21,"year":13,"amount":14,"abstract":202},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-alw-016-161-320","Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes","Katja Apelt","Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as we",34,{"programme":8,"total":205,"withPiName":205,"firstYear":206,"lastYear":207,"countryCount":208,"perYear":209,"topInstitutions":259,"topCountries":310},788,2008,2026,33,[210,212,215,217,220,223,226,229,232,235,238,241,244,245,248,251,254,257],{"year":206,"count":211},1,{"year":213,"count":214},2009,2,{"year":216,"count":211},2011,{"year":218,"count":219},2012,3,{"year":221,"count":222},2013,5,{"year":224,"count":225},2014,6,{"year":227,"count":228},2015,15,{"year":230,"count":231},2016,41,{"year":233,"count":234},2017,58,{"year":236,"count":237},2018,114,{"year":239,"count":240},2019,28,{"year":242,"count":243},2020,39,{"year":13,"count":203},{"year":246,"count":247},2022,37,{"year":249,"count":250},2023,66,{"year":252,"count":253},2024,116,{"year":255,"count":256},2025,133,{"year":207,"count":258},89,[260,262,264,267,269,270,271,273,275,277,279,281,283,285,287,289,291,294,296,299,300,302,304,305,307],{"name":57,"count":261},63,{"name":95,"count":263},60,{"name":265,"count":266},"University of Groningen",52,{"name":51,"count":268},40,{"name":190,"count":247},{"name":179,"count":240},{"name":45,"count":272},25,{"name":89,"count":274},19,{"name":27,"count":276},17,{"name":278,"count":276},"Erasmus MC",{"name":280,"count":276},"Maastricht University",{"name":146,"count":282},16,{"name":33,"count":284},14,{"name":101,"count":286},12,{"name":288,"count":286},"University Medical Center Utrecht",{"name":157,"count":290},11,{"name":292,"count":293},"Centre National de la Recherche Scientifique",8,{"name":295,"count":293},"Institute for Atomic and Molecular Physics",{"name":297,"count":298},"Netherlands Institute of Ecology",7,{"name":196,"count":298},{"name":301,"count":225},"Amsterdam University of Applied Sciences",{"name":303,"count":225},"Netherlands Institute for Neuroscience",{"name":126,"count":225},{"name":306,"count":222},"Royal Netherlands Institute for Sea Research",{"name":308,"count":309},"Amsterdam University Medical Centers",4,[311,313,316,318,321,324,327,328,330,332,333,335,336,338,340,341,343,345,347,349,351,353,355,357,359],{"name":21,"count":312},558,{"name":314,"count":315},"DE",30,{"name":140,"count":317},27,{"name":319,"count":320},"GB",21,{"name":322,"count":323},"FR",13,{"name":325,"count":326},"BE",9,{"name":120,"count":326},{"name":329,"count":293},"IT",{"name":331,"count":298},"CN",{"name":40,"count":222},{"name":334,"count":222},"CA",{"name":12,"count":222},{"name":337,"count":222},"ES",{"name":339,"count":309},"AT",{"name":108,"count":309},{"name":342,"count":219},"IE",{"name":344,"count":214},"HU",{"name":346,"count":214},"PL",{"name":348,"count":214},"SE",{"name":350,"count":214},"SG",{"name":352,"count":214},"ZA",{"name":354,"count":211},"AE",{"name":356,"count":211},"AR",{"name":358,"count":211},"BD",{"name":360,"count":211},"CL"]