[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"grant-nihr-efficacy-and-mechanism-evaluation-programme-2026":3,"similar-nihr-efficacy-and-mechanism-evaluation-programme-2026":27},{"id":4,"name":5,"funder":6,"link":7,"budget":8,"budget_min_eur":8,"budget_max_eur":8,"deadline":8,"deadline_note":8,"duration":8,"trl":8,"relevance":8,"why_relevant":8,"early_career":9,"consortium":8,"first_seen":10,"last_updated":8,"update_note":8,"status":11,"stages":12,"call_frequency":8,"next_call_expected":8,"source_url":7,"created_at":13,"updated_at":14,"eligible_countries":15,"description":17,"seo_summary":18,"recurring_round":9,"canonical_id":4,"links":19},"nihr-efficacy-and-mechanism-evaluation-programme-2026","Efficacy and Mechanism Evaluation Programme","NIHR","https:\u002F\u002Fwww.nihr.ac.uk\u002Ffunding\u002Feme-programme-researcher-led\u002F2026483",null,false,"2026-08-13T00:00:00.000Z","open","2-stage: outline application → full application","2026-08-13T08:21:39.232Z","2026-08-13T08:26:03.426Z",[16],"GB","Researcher-led call funding efficacy and mechanism evaluation studies requiring proof of concept in humans. Must be hypothesis-driven; hypothesis-generating studies are ineligible. Requires patient\u002Fpublic involvement in study co-design. Clinical trials must comply with UK MHRA regulations and engage an accredited UKCRC Clinical Trials Unit. Host institution must be a UK organisation ('domestic' applications).","{\"summary\":\"The NIHR Efficacy and Mechanism Evaluation Programme funds hypothesis-driven efficacy and mechanism evaluation studies requiring proof of concept in humans, delivered by UK-based research teams. The call is researcher-led and requires patient and public involvement in study co-design, along with compliance with UK MHRA regulations for clinical trials and engagement of an accredited UKCRC Clinical Trials Unit. This is a two-stage process with outline and full application rounds.\",\"meta_description\":\"NIHR Efficacy and Mechanism Evaluation Programme funds hypothesis-driven efficacy studies with human proof of concept, based in UK institutions, from NIHR.\",\"who_should_apply\":[\"UK-based research teams at accredited institutions\",\"Researchers designing hypothesis-driven efficacy and mechanism evaluation studies\",\"Teams planning clinical trials compliant with UK MHRA regulations\",\"Applicants committed to meaningful patient and public involvement in study design\",\"Studies with clear proof-of-concept objectives in human subjects\"],\"key_dates\":[\"Two-stage application: outline application followed by full application (verify dates on NIHR site)\",\"Clinical trials must be registered and comply with UK MHRA requirements\",\"Host institution must be a UK organisation\"],\"tips\":[\"Patient and public involvement is mandatory and scored, embed it in co-design from the proposal stage, not as an afterthought.\",\"Clinical trials require upfront engagement with an accredited UKCRC Clinical Trials Unit; delays in trial design will slow your application.\",\"Hypothesis-driven studies only: clearly state your a priori hypotheses and distinguish them from exploratory or mechanism-generating aims.\"],\"faq\":[{\"q\":\"What types of studies does the NIHR Efficacy and Mechanism Evaluation Programme fund?\",\"a\":\"Hypothesis-driven efficacy and mechanism evaluation studies requiring proof of concept in humans; hypothesis-generating studies are ineligible.\"},{\"q\":\"Do I need patient involvement for NIHR Efficacy and Mechanism Evaluation applications?\",\"a\":\"Yes, patient and public involvement in study co-design is mandatory for all applications.\"},{\"q\":\"Can I run a clinical trial through this programme?\",\"a\":\"Yes, but clinical trials must comply with UK MHRA regulations and engage an accredited UKCRC Clinical Trials Unit.\"},{\"q\":\"Where can I host an NIHR Efficacy and Mechanism Evaluation study?\",\"a\":\"Host institutions must be UK-based organisations; overseas applicants are not eligible.\"}],\"tags\":[\"nihr\",\"efficacy-evaluation\",\"clinical-trials\",\"mechanism-of-action\",\"hypothesis-driven\",\"patient-involvement\",\"uk-based\"]}",{"matchedProgram":8,"resourceSlug":8,"relatedGuides":20,"countryHubs":21,"domainHubs":25,"closingMonth":8,"hasRelated":9,"hasBrowseRelated":26},[],[22],{"slug":23,"demonym":24},"gb","UK researchers",[],true,{"grants":28},[29,32,35,38,44],{"id":30,"name":31,"funder":6,"deadline":8,"budget":8},"nihr-eme-programme-researcher-led-2026","EME Programme Researcher-Led",{"id":33,"name":34,"funder":6,"deadline":8,"budget":8},"nihr-james-lind-alliance-priority-setting-partnerships-2026","James Lind Alliance Priority Setting Partnerships",{"id":36,"name":37,"funder":6,"deadline":8,"budget":8},"nihr-hta-researcher-led-primary-research-2026","HTA Researcher-Led Primary Research",{"id":39,"name":40,"funder":41,"deadline":42,"budget":43},"cancer-research-uk-clinical-research-funding-scheme-2026-12","Clinical Research Funding Scheme","Cancer Research UK","2026-12-03T00:00:00.000Z","Flexible; module dependent",{"id":45,"name":46,"funder":6,"deadline":8,"budget":8},"nihr-phr-researcher-led-2026","PHR Researcher-Led"]