MRC (UKRI)
Proof of Concept
4:00pm UK time
Last updated:
The MRC Proof of Concept call funds academically-led translational projects developing novel therapeutics, devices, diagnostics or interventions from early prototype through phase 2a clinical studies. Project leads must be employed by a UK research organisation, though international researchers may co-lead; the MRC funds 80% of full economic costs with no requirement for matched funding beyond the standard 20%. This is a competitive, two-stage call with no stated budget cap per project.
Details
| Funder | MRC (UKRI) |
| Budget | No limit stated; 80% FEC funded |
| Deadline | 18 November 2026 |
| Duration | No limit; projects start 1–6 months after funding decision |
| Consortium | No |
| Application | 2-stage: stage one application → invited stage two |
| Eligible countries | GB |
Eligibility & scope
Academically-led translational projects developing novel therapeutics, devices, diagnostics or interventions from early prototype through to phase 2a clinical studies. Project lead must be employed by an eligible UK research organisation; international researchers may participate as project co-lead (international). Funds 80% FEC; no matched funding required beyond standard 20% FEC.
Who Should Apply
- •Project leads employed by eligible UK research organisations (universities, NHS trusts, research institutes)
- •Translational researchers with early-stage prototype or candidate therapeutic, device, diagnostic or intervention
- •Teams ready to progress toward phase 2a clinical studies
- •Applicants comfortable with two-stage competitive review; international co-leads welcome but project lead must be UK-based
Key Dates
- •Deadline: 18 November 2026, 4:00pm UK time
- •Two-stage process: stage one written application followed by invited stage two
- •Projects begin 1-6 months after funding decision
Tips for Applicants
- ✓Translational stage and clinical progression pathway are central: articulate clearly how the prototype moves toward phase 2a and what de-risks that journey.
- ✓The 80% FEC model means your host organisation covers only 20%, check whether your institution will absorb this before applying.
- ✓International co-leads strengthen global relevance, but the project lead's UK employment is non-negotiable for eligibility.
Frequently Asked Questions
Who can be the project lead for an MRC Proof of Concept grant?
The project lead must be employed by an eligible UK research organisation. International researchers may participate as a project co-lead but cannot be the lead applicant.
What funding level does MRC Proof of Concept offer?
The MRC funds 80% of full economic costs (FEC); your host organisation covers the remaining 20% and no additional matched funding is required.
What is the deadline for MRC Proof of Concept?
The deadline is 18 November 2026 at 4:00pm UK time, using a two-stage application process.
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